Collaborative Observational Study of Myopia in COMET Children 2: Clinial Ceneter

描述(由申请人提供)：这项建议是阿拉巴马大学伯明翰临床中心继续每年检查目前登记的127名COSMICC参与者(自1997-98年登记以来只有5名受试者失去随访)，在COSMICC2方案之后的额外5年(总随访14年)。从这个中心收集的数据将被用来解决主席申请中更详细描述的具体目标，并在这里简要总结：1)使用数学函数(Gompertz函数和其他函数)来模拟58%的COSMICC进行性近视受试者的近视进展，并基于先前确定的风险因素(年龄、种族、父母近视)开发预测模型和测试假说；2)在这个特征良好的近视队列中测试与近视进展和稳定以及眼轴延长的环境风险因素有关的4个假说；3)对COSMICC受试者近视相关眼压、CCT和黄斑厚度变化的危险因素进行三个假设检验。近视的高患病率(占美国成年人口的25%)及其作为公共卫生问题的突出(可能导致视力丧失和失明的危险因素)强调了增加对进展和最终稳定的机制的了解的重要性，以便将来近视可能被限制在低水平。更好地了解近视进展和稳定的预测因素也将有助于指导干预措施的选择和时机，并针对那些可能从治疗中受益最大的群体。

DESCRIPTION (provided by applicant): This proposal is for the University of Alabama at Birmingham Clinical Center to continue to annually examine the 127 currently enrolled COSMICC participants (only 5 subjects are lost to follow-up since enrollment in 1997-98) for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.