PROTEOMICS SHARED RESOURCE

蛋白质组学共享资源为奈特癌症研究所成员提供了现代的质谱学工具，以便他们可以确定蛋白质中发生的身份、丰度和修饰，蛋白质是细胞的组成部分。这些分析对于了解癌症的原因和设计改进的治疗方法至关重要，因为所有形式的癌症都会发生蛋白质的变化。支持将是 用于部分资助五名员工和四台最先进的质谱仪的工资，以协助骑士调查人员研究蛋白质的致癌变化，包括磷酸化、乙酰化、丰度变化和与其他蛋白质结合的变化。还将向骑士成员提供广泛的信息学工具和专业知识，以提高他们的研究效率。蛋白质组学的研究结果 共享资源将被用来更好地治疗癌症患者，方法是提供疾病的早期诊断，并发现针对个别患者的更有效的治疗方法。

The Proteomics Shared Resource provides modern tools of mass spectrometry to Knight Cancer Institute members so that they may determine the identity, abundance, and modifications occurring in proteins, the building blocks of the cell. These analyses are crucial to understanding the cause of cancer and devising improved treatments for the disease, since changes in proteins occur in all forms of cancer. Support will be used to partially fund salaries of five staff and four state-of-the-art mass spectrometers to assist Knight investigators studying cancer-causing changes in proteins, including phosphorylation, acetylation, changes in abundance and altered binding to other proteins. A wide array of informatics tools and expertise will also be provided to Knight members to increase their research productivity. The results from the Proteomics Shared Resource will be used to better treat cancer patients by providing earlier diagnosis of the disease and discovering more effective treatments that are personalized for individual patients.