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PROTEOMICS SHARED RESOURCE

PROTEOMICS SHARED RESOURCE
蛋白质组学共享资源
批准号：
8340104
负责人：
BRIAN J DRUKER
金额：
$6.13万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-20 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8340104
关键词：
AcetylationApplications GrantsBindingBiologicalCancer Center Support GrantCancer EtiologyCancer PatientCellsCerebrospinal FluidComplexDataDiseaseDissociationEarly DiagnosisElectron TransportFundingHealth SciencesIndividualInformaticsInstitutesInstructionLabelLiquid substanceMalignant NeoplasmsMass Spectrum AnalysisModificationOregonPatientsPhosphorylationPost-Translational Protein ProcessingProductivityProteinsProteomicsProteomics Shared ResourceRelative (related person)ResearchResearch PersonnelSalivaSamplingSerumSpeedStable Isotope LabelingSubcellular FractionsTechniquesTechnologyTissuesUniversitiesUrineWagesWorkWritinganticancer researcheffective therapyimprovedmass spectrometermembertool

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The Proteomics Shared Resource provides modern tools of mass spectrometry to Knight Cancer Institute members so that they may determine the identity, abundance, and modifications occurring in proteins, the building blocks of the cell. These analyses are crucial to understanding the cause of cancer and devising improved treatments for the disease, since changes in proteins occur in all forms of cancer. Support will be used to partially fund salaries of five staff and four state-of-the-art mass spectrometers to assist Knight investigators studying cancer-causing changes in proteins, including phosphorylation, acetylation, changes in abundance and altered binding to other proteins. A wide array of informatics tools and expertise will also be provided to Knight members to increase their research productivity. The results from the Proteomics Shared Resource will be used to better treat cancer patients by providing earlier diagnosis of the disease and discovering more effective treatments that are personalized for individual patients.
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Proteogenomic characterization of early and late resistance mechanisms in acute myeloid leukemia
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