PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

• 批准号: 8206048
• 负责人: GAIL A GREENDALE
• 金额: $ 13.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8206048
• 关键词: Address; Affect; Age; Aging; American; Award; Basic Science; Biological Markers; Bone Marrow; Bone Transplantation; Calculi; Caring; Cell Therapy; Cells; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Complex; Defect; Development; Diagnostic; Discipline; Doctor of Philosophy; Elderly; Environment; Faculty; Fostering; Funding; Gene Expression; Geriatrics; Goals; Grant; Health; Implantation procedure; Infusion procedures; Instruction; Interdisciplinary Study; Intervention; Laboratories; Lead; Leadership; Mammographic Density; Mandible; Manuscripts; Medicine; Menopause; Mentors; Mentorship; Methodology; Mitochondria; Modeling; Monitor; Muscle; Organ Transplantation; Osteoporosis; Outcome; Pathology; Patients; Peer Review; Physical Function; Pilot Projects; Play; Process; Psychosocial Factor; Reporting; Request for Proposals; Research; Research Infrastructure; Research Personnel; Role; Science; Scientist; Series; Staging; Stromal Cells; Translational Research; Translations; Work; age related; base; career; clinical practice; edentulism; evidence base; falls; functional loss; immunosenescence; improved; innovation; long bone; meetings; multidisciplinary; muscle form; novel; professor; programs; routine practice; sarcopenia; treatment strategy

Overview. The overarching purpose of the UCLA Pilot Exploratory Studies Core (PESC) is to promote innovative basic, clinical and translational research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA's research theme and carries out the Center's goals. These studies will have one or more of the following objectives: a) provide preliminary studies on which subsequent, larger basic or clinical investigations will be based, b) develop new basic or clinical methodologies that surmount critical barriers to progress in a given discipline, thus opening new research avenues; c) develop novel multidisciplinary research approaches to address complex geriatrics research questions; d) accomplish bidirectional basic and clinical sciences translation; and e) identify diagnostic and/or treatment strategies that bring discoveries to the bedside in order to improve health and optimize function of geriatric patients. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, who conducts research in menopause, mammographic density, osteoporosis, & physical functioning, will lead the PESC multidisciplinary team. The co-leaders will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine, who studies immunosenescence and Peifeng Hu, PhD, MD, Assoc. Professor of Medicine/Geriatrics, who studies relations among biomarkers, psychosocial factors and health outcomes in older adults. Pilot Processes. There will be clear processes for selection of full pilots, monitoring progress of pilots, and developing pilots into independently funded research awards. Selection will consist of a staged process that includes a request for proposals; request for full applications from meritorious applicants; and a series of reviews culminating with final selection by the Executive Committee, External Advisory Board and External Selection Panel. Each pilot will be monitored by a PESC liaison; monitoring will include monthly reports; quarterly meetings with the liaison; annual presentation at the OAIC Seminar Series; and annual presentation to the External Advisors. There will also be a rapid pilot program for which we have set aside $25K to make awards during year 1. The rapid pilot program will make fast-turn-around grants of up to $10,000, to allow the research of junior investigators to advance expediently. Pilots. Three full pilots are proposed. These are: 1) Gene expression analysis of age-related, focal muscle mitochondrial defects;2) Mandibular vs. long bone marrow stromal cell based therapy for implant placement; 3) How do new models of care for older adults spread into routine practice?

概况.加州大学洛杉矶分校试点探索性研究核心（PESC）的首要目的是促进创新的基础，临床和转化研究，由初级和高级研究人员合作团队进行，福尔斯属于加州大学洛杉矶分校的研究主题，并实现中心的目标。这些研究将有以下一个或多个目标：a）提供初步研究，为后续更大规模的基础或临床研究奠定基础，B）开发新的基础或临床方法，克服特定学科进展的关键障碍，从而开辟新的研究途径; c）开发新的多学科研究方法，以解决复杂的老年医学研究问题; d）实现基础和临床科学的双向转化;以及e）确定诊断和/或治疗策略，将发现带到床边，以改善老年患者的健康并优化其功能。 领导盖尔格林德尔，医学博士，医学/老年医学教授，谁在更年期，乳房摄影密度，骨质疏松症和身体功能进行研究，将领导PESC多学科团队。共同领导人将是Rita Effros博士，病理学/实验室医学教授，他研究免疫衰老和Peifeng Hu博士，医学博士，医学/老年医学副教授，他研究生物标志物，心理社会因素和老年人健康结果之间的关系。 试点进程。将有明确的程序来选择正式试点，监测试点的进展， 将试点项目发展为独立资助的研究奖项。甄选将包括一个分阶段的过程，其中包括征求建议书;要求优秀申请人提出完整的申请;以及一系列审查，最终由执行委员会、外部咨询委员会和外部甄选小组进行最后甄选。每个试点项目都将由一名公共行政和安全协调委员会联络员进行监测;监测工作将包括每月报告;与联络员举行季度会议;每年在审计和调查办公室系列研讨会上介绍情况;每年向外部顾问介绍情况。我们还将推出一个快速试点项目，我们已拨出2.5万美元在第一年进行奖励。快速试点计划将使快速周转赠款高达 10 000美元，使初级调查员的研究工作能够迅速取得进展。 飞行员三是全面试点。这些是：1）年龄相关的局灶性肌线粒体缺陷的基因表达分析;2）下颌骨与长骨髓基质细胞为基础的治疗种植体植入; 3）老年人护理的新模式如何推广到日常实践中？