PILOT AND EXPLORATORY STUDIES CORE

概述。加州大学洛杉矶分校先导探索性研究核心(PESC)的总体目的是促进创新的基础、临床和转化研究，这些研究由初级和高级研究人员组成的合作团队进行，符合加州大学洛杉矶分校的研究主题并实现中心的目标。这些研究将有以下一个或多个目标：a)提供初步研究，作为后续更大规模的基础或临床研究的基础；b)开发新的基础或临床方法，克服某一学科取得进展的关键障碍，从而开辟新的研究途径；c)开发新的多学科研究方法，以解决复杂的老年病学研究问题；d)完成基础科学和临床科学的双向翻译；以及e)确定将发现带到床边的诊断和/或治疗策略，以改善老年患者的健康和优化其功能。 领导力。盖尔·A·格林代尔，医学博士，医学/老年病学教授，从事更年期、乳房摄影密度、骨质疏松症和身体功能的研究，将领导PESC多学科团队。共同领导将是Rita Effros博士，病理学/实验室医学教授，研究免疫衰老，以及胡培峰，博士，医学博士，Assoc。医学/老年病学教授，研究生物标记物、心理社会因素和老年人健康结果之间的关系。 试行流程。将有明确的程序来选择完整的飞行员，监测飞行员的进度，以及 将试点发展为自主资助的研究奖项。遴选将包括一个分阶段的过程，其中包括征求建议书；征求优秀申请者的完整申请；以及一系列审查，最终由执行委员会、外部咨询委员会和外部遴选小组进行最终选择。每名飞行员将由一名PESC联络员进行监测；监测工作将包括每月报告；与联络员每季度举行一次会议；在伊斯兰会议组织系列研讨会上作年度介绍；以及每年向外部顾问介绍情况。我们还将在第一年为快速试点计划预留25K美元的奖励。快速试点计划将提供高达 1万美元，让初级调查人员的研究工作得以便利地进行。 飞行员。三个完整的试点计划被提出。这些是：1)年龄相关的局灶性肌肉线粒体缺陷的基因表达分析；2)基于下颌或长骨髓基质细胞的种植体植入治疗；3)新的老年人护理模式如何推广到常规实践中？

Overview. The overarching purpose of the UCLA Pilot Exploratory Studies Core (PESC) is to promote innovative basic, clinical and translational research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA's research theme and carries out the Center's goals. These studies will have one or more of the following objectives: a) provide preliminary studies on which subsequent, larger basic or clinical investigations will be based, b) develop new basic or clinical methodologies that surmount critical barriers to progress in a given discipline, thus opening new research avenues; c) develop novel multidisciplinary research approaches to address complex geriatrics research questions; d) accomplish bidirectional basic and clinical sciences translation; and e) identify diagnostic and/or treatment strategies that bring discoveries to the bedside in order to improve health and optimize function of geriatric patients. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, who conducts research in menopause, mammographic density, osteoporosis, & physical functioning, will lead the PESC multidisciplinary team. The co-leaders will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine, who studies immunosenescence and Peifeng Hu, PhD, MD, Assoc. Professor of Medicine/Geriatrics, who studies relations among biomarkers, psychosocial factors and health outcomes in older adults. Pilot Processes. There will be clear processes for selection of full pilots, monitoring progress of pilots, and developing pilots into independently funded research awards. Selection will consist of a staged process that includes a request for proposals; request for full applications from meritorious applicants; and a series of reviews culminating with final selection by the Executive Committee, External Advisory Board and External Selection Panel. Each pilot will be monitored by a PESC liaison; monitoring will include monthly reports; quarterly meetings with the liaison; annual presentation at the OAIC Seminar Series; and annual presentation to the External Advisors. There will also be a rapid pilot program for which we have set aside $25K to make awards during year 1. The rapid pilot program will make fast-turn-around grants of up to $10,000, to allow the research of junior investigators to advance expediently. Pilots. Three full pilots are proposed. These are: 1) Gene expression analysis of age-related, focal muscle mitochondrial defects;2) Mandibular vs. long bone marrow stromal cell based therapy for implant placement; 3) How do new models of care for older adults spread into routine practice?