An Administrative Research Supplement to Support Diversity for Parent Grant Extending Sleep to Improve Glycemia in Pediatric Type 1 Diabetes

延长睡眠时间改善儿童1型糖尿病患者的血糖 RDK110528-A 项目摘要 越来越多的数据支持睡眠和新陈代谢功能之间的联系。我们 先前发现，各种睡眠参数与血糖控制和 心理社会功能。不幸的是，在标准的临床中，睡眠并不是常规的问题。 关爱患有1型糖尿病(T1 DM)的青少年。需要一项实验研究来验证 睡眠时间对青少年血糖控制和神经行为功能的直接影响 患有1型糖尿病。因此，我们的主要研究目的是：(1)测试睡眠是否延长 改善血糖控制和患有T1 DM的青年；(2)评估“助推器”治疗是否可以 有助于维持睡眠时间；以及(3)评估“助推器”训练是否能在统计上导致 血糖控制的黄金标准HbA1c的临床意义变化。在 建议的随机研究，多达175名患有T1 DM的青年(年龄从10岁到17岁)将被分配 到睡眠延长或控制条件。延长睡眠时间可以延长年轻人的卧床时间 以允许健康的睡眠持续时间，而控制条件不会强制 规定的睡眠时间表；它控制时间和注意力。我们将测试睡眠的影响 推广血糖控制的关键指标(平均血糖水平和在范围内的时间百分比)和 次要利益(例如，生活质量、糖尿病相关的痛苦和社会情绪 功能、创伤应激症状)；检查坚持的中介作用，并探索 生理影响途径(例如，心率变异性(HRV)、皮质醇水平)一旦我们 目标实现了，并建立了因果联系，拟议的睡眠延长干预 将促进对睡眠在糖尿病管理中作用的了解，并提供 对青少年1型糖尿病患者进行有益的干预。

Extending Sleep to Improve Glycemia in Pediatric Type 1 Diabetes RDK110528-A Project Abstract Data have increasingly supported the association of sleep and metabolic functioning. We previously found that various sleep parameters are associated with glucose control and psychosocial functioning. Unfortunately, sleep is not routinely addressed in standard clinical care for youth with type 1 diabetes mellitus (T1DM). An experimental study is needed to verify the direct impact of sleep duration on glycemic control and neurobehavioral functioning in youth with type 1 diabetes. Therefore, our primary study aims are to (1) Test if lengthening sleep improves glycemic control and in youth with T1DM; (2) Assess if “booster” sessions can contribute to sustained sleep length; and (3) Assess if “booster” sessions can lead to statistically and clinically meaningful changes in HbA1c, the gold standard of glucose control. In the proposed randomized study, up to 175 youth (ages 10 through 17) with T1DM will be assigned to a Sleep Extension or a Control condition. The Sleep Extension lengthens youth's time in bed to allow for a healthy sleep duration, whereas the control condition does not impose a prescribed sleep schedule; it controls for time and attention. We will test the impact of sleep extension on key indices of glycemic control (average glucose levels and % time in range) and secondary benefits (e.g., quality of life, diabetes-related distress, and social-emotional functioning, traumatic stress symptoms); examine the mediating role of adherence, and explore physiological pathways of effect (e.g., heart rate variability (HRV), cortisol levels) Once our aims are achieved and a causal link is established, the proposed Sleep Extension intervention will advance knowledge about the role of sleep in diabetes management and provide a beneficial intervention to help youth with T1DM.