Identifying Biomarkers that Modify Outcomes in Soccer Heading

识别改变足球标题结果的生物标志物

• 批准号: 9465237
• 负责人: Liane Elizabeth Hunter
• 金额: $ 3.46万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-21 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9465237
• 关键词: Alleles; Alzheimer' s Disease; Apolipoprotein E; Attenuated; Basic Science; Biological Markers; Brain; Brain Concussion; Brain Injuries; Brain-Derived Neurotrophic Factor; Characteristics; Clinical; Clinical Investigator; Clinical Research; Cognition; Cognitive; Cohort Studies; Craniocerebral Trauma; Deterioration; Development; Diffusion Magnetic Resonance Imaging; Exercise; Fostering; Foundations; Functional disorder; Genes; Genetic Polymorphism; Goals; Guidelines; Head; Heterogeneity; Impaired cognition; Impairment; Individual; Inflammatory; Injury; Interleukin-1 beta; Interleukin-6; Laboratories; Magnetic Resonance Imaging; Memory impairment; Mentorship; Modality; Nerve Degeneration; Neurodegenerative Disorders; New York City; Outcome; Pathologic; Pathology; Patient Outcomes Assessments; Patients; Performance; Play; Process; Proteins; Reporting; Research; Research Methodology; Research Personnel; Risk; Role; Single Nucleotide Polymorphism; Soccer; Sports; Synaptic plasticity; TNF gene; Techniques; Time; Tissues; Training; Traumatic Brain Injury; Uncertainty; United States; Valine; Work; adverse outcome; apolipoprotein E-4; axon injury; base; biological adaptation to stress; cognitive performance; cytokine; gene interaction; memory process; mild traumatic brain injury; neurogenesis; neuroinflammation; neurotrophic factor; neurotropic; normal aging; processing speed; public health intervention; response; sterol esterase; trait; young adult

Abstract The effects of repetitive heading in soccer, outside the purview of recognized concussion, are a topic of major public importance that has not been well defined. Recent work from our laboratory has shown that repetitive sub-concussive soccer heading is associated with evidence of microstructural tissue damage as well as cognitive impairments. We have found that there exists a threshold number of heads per year whereby subclinical and clinical impairments are evident. Despite this evidence of axonal and functional damage, we have not characterized individuals at greater and/or reduced risk for deterioration from repetitive soccer heading. In this proposed study we will investigate trait biomarkers hypothesized to have an association with neurodegenerative processes subsequent to brain injury. Specifically, we will examine the effect-modifying role of the Apolipoprotein E, Cholesterol Esterase Transfer Protein and Brain Derived Neurotrophic Factor polymorphisms. Furthermore, we will explore the extent to which the ex-vivo inflammatory stress response can explain the heterogeneity in outcomes. Under the mentorship of Dr. Michael Lipton and investigators with varying expertise pertaining to the project, I am confident that I will accomplish my goal of identifying biomarkers that confer greater vulnerability to heading related impairments. Furthermore, I will receive excellent training in clinical research methods and basic science techniques alike, which will serve as an excellent foundation for my ultimate goal of becoming an independent clinical Investigator.

摘要 足球中重复头球的影响，超出了公认的脑震荡的范围，是一个话题， 重要的公共意义，尚未得到很好的界定。我们实验室最近的研究表明 重复的亚震荡性足球头球与微结构组织的证据有关 以及认知障碍。我们发现，存在一个阈值数量， 其中亚临床和临床损害是明显的。尽管有证据表明 轴突和功能损伤，我们还没有特征的个人在更大和/或减少的风险， 反复头球导致的恶化。在这项拟议的研究中，我们将调查性状生物标志物 假设与脑损伤后的神经退行性过程有关。 具体来说，我们将研究载脂蛋白E，胆固醇酯酶的作用修饰作用 转移蛋白和脑源性神经营养因子多态性。此外，我们将探索 离体炎症应激反应在多大程度上可以解释 结果。在迈克尔·利普顿博士和具有不同专业知识的研究人员的指导下， 关于这个项目，我相信我将完成我的目标，确定生物标志物， 使更容易受到与航向有关的损害。此外，我将接受出色的培训 在临床研究方法和基础科学技术一样，这将是一个很好的 我的最终目标是成为一名独立的临床研究者。