DEVELOPMENT OF MEDICAL COUNTERMEASURES TO MITIGATE AND/OR TREAT RADIATION-INDUCED LUNG INJURY AFTER A RADIOLOGICAL/NUCLEAR INCIDENT)

制定医疗对策以减轻和/或治疗放射/核事件后辐射引起的肺损伤）

• 批准号: 9476857
• 负责人: ANDREW NORRIS
• 金额: $ 182.8万
• 依托单位: BCN BIOSCIENCES, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9476857
• 关键词: Benefits and Risks; Biological Markers; Chemistry; Contracts; Coupled; Data; Development; Drug Kinetics; Drug usage; Exposure to; Goals; Hour; Injury; Ionizing radiation; Lead; Lung; Medical; Metabolism; Modeling; Morbidity - disease rate; Nuclear; Nuclear Radiology; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology and Toxicology; Radiation; Radiation exposure; Radiology Specialty; Research; Research Support; Testing; Therapeutic; Work; animal rule; design; efficacy study; lung injury; model development; programs; radiation mitigator; subcutaneous

This contract will support research to accelerate the development of safe and effective medical products to mitigate and/or treat pulmonary injury arising from exposure to ionizing radiation from a radiological or nuclear incident, thereby leading to a reduction in lung-associated morbidities that can impact survival. Currently, there are no approved therapeutic products in the Strategic National Stockpile (SNS) to be used specifically for radiation-induced pulmonary injury.

该合同将支持加速开发安全有效的医疗产品的研究，以减轻和/或治疗因辐射或核事故而暴露于电离辐射所引起的肺损伤，从而减少可能影响生存的与肺相关的发病率。目前，国家战略储备(SNS)中还没有批准的专门用于放射性肺损伤的治疗产品。