Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
基本信息
- 批准号:9323659
- 负责人:
- 金额:$ 32.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAge-associated memory impairmentAgingAgreementAlzheimer&aposs DiseaseAphasiaArchitectureAttentionBehavioralClinicalCognitiveCognitive TherapyCommunicationCommunitiesComprehensionDiffusion Magnetic Resonance ImagingDiseaseDorsalElderlyEventExhibitsFailureFibrinogenFoundationsFrequenciesFunctional Magnetic Resonance ImagingFundingGenerationsGoalsHealthImpaired cognitionImpairmentIndependent LivingIndividualInterventionKnowledgeLanguageLinkLiteratureMagnetic Resonance ImagingMeasuresMediationMemoryNamesNaturePatientsPerformancePopulationProductionQuality of lifeRehabilitation therapyResearchRetrievalSemanticsSeriesSpeechSpeedStutteringSystemTestingTimeWorkage relatedbasebehavior measurementbrain behaviorcognitive abilityexperienceexperimental studyhealthy agingimprovedindexinginsightlanguage comprehensionlexicallexical retrievalmild cognitive impairmentmultimodalityneuroimagingphonologypre-clinicalprocessing speedrelating to nervous systemtheoriestongue apextransmission processwhite matter
项目摘要
Project Summary / Abstract
Older adults exhibit decreased speed and accuracy in naming objects, more slips of the tongue, more
pauses in speech, and more tip-of-the-tongue experiences, in which one cannot produce a word even
though there is a vivid sense of knowing it. Importantly, older adults rank these experiences as a frustrating,
embarrassing, and frequent memory problem. While word retrieval failures reflect a common aspect of
aging that affects the vast majority of older individuals, the neural bases of language production in healthy
aging has received little attention. Research suggests that these failures result from a phonological deficit.
Indeed, results from the prior funding period demonstrated significant age-related decline and weakened
brain-behavior links underlying phonological aspects of language production. However, we have only begun
to examine the causal factors that contribute to word retrieval difficulty. Thus, the overarching goal of the
present proposal is to use behavioral measures, functional magnetic resonance imaging (fMRI), and
diffusion tensor imaging (DTI) to investigate the causal factors that contribute to age-related declines in
word retrieval. We propose a series of 5 experiments that will investigate the influence of lexical and
behavioral factors that contribute to word retrieval difficulty to advance theoretical accounts of age-related
differences in language production. The multimodal approach will allow us to examine the relations between
cognitive abilities, language production, and neural factors such as white matter integrity and functional
activation in healthy aging. Our long-term goal is to advance theoretical accounts of age-related differences
in language production. Our work is guided by the Transmission Deficit Theory (TDT), which proposes that
age weakens connections within the language system, and that age-related transmission deficits disrupt
word production more than word comprehension because of differences between the architecture of
phonological and semantic representations. This research will improve the current scientific understanding
of age-related changes in language, and provide a characterization of the neural factors that contribute to
cognitive decline. These results will provide essential information for differentiating normal age-related
changes in language from the effects of disease, forge advances in our theoretical conceptualization of age-
related differences in language, and provide insight into rehabilitative therapies for cognitive decline in both
healthy aging and clinical patients.
项目总结/摘要
老年人在命名物体时表现出速度和准确性下降,更多的口误,
说话停顿,更多的舌尖体验,其中一个人甚至不能产生一个词
重要的是,老年人认为这些经历是令人沮丧的,
令人尴尬的频繁记忆问题虽然单词检索失败反映了一个共同的方面,
衰老影响着绝大多数老年人,健康人语言产生的神经基础
老龄化很少受到关注。研究表明,这些失败是由于语音缺陷。
事实上,上一个供资期的结果显示,
大脑行为联系语言产生的语音方面。然而,我们才刚刚开始
探讨导致单词提取困难的原因。因此,
目前的建议是使用行为测量,功能磁共振成像(fMRI),
扩散张量成像(DTI),以调查导致年龄相关性下降的因果因素,
单词检索我们提出了一系列的5个实验,将调查词汇和
行为因素,有助于词检索困难,以推进理论帐户的年龄相关的
语言生产的差异。多式联运的方法将使我们能够检查之间的关系,
认知能力、语言产生和神经因素,如白色物质完整性和功能
健康老龄化中的激活。我们的长期目标是推进年龄相关差异的理论解释
语言生产。我们的工作以传输赤字理论(TDT)为指导,该理论提出,
年龄会削弱语言系统内的联系,与年龄相关的传输缺陷会破坏
单词产生比单词理解更重要,因为
语音和语义表征。这项研究将提高当前的科学认识
年龄相关的语言变化,并提供了一个表征的神经因素,有助于
认知能力下降这些结果将为鉴别正常的年龄相关性
疾病影响下语言的变化,推动了我们对年龄的理论概念化,
相关的语言差异,并提供了对认知能力下降的康复治疗的见解,
健康老龄化和临床患者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michele T Diaz其他文献
Michele T Diaz的其他文献
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{{ truncateString('Michele T Diaz', 18)}}的其他基金
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
8461172 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
7887443 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
8663781 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
8961001 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
8279366 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
Neuroimaging of Age-Related Changes in Language
与年龄相关的语言变化的神经影像学
- 批准号:
8067909 - 财政年份:2010
- 资助金额:
$ 32.83万 - 项目类别:
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