Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program

项目概要/摘要 推进结直肠癌 (CRC) 筛查研究，支持博拜登癌症项目的目标 MoonshotSM 倡议，RTI International 提议充当该项目的协调中心 (CC) 通过实施科学 (ACCSIS) 加速结直肠癌筛查和随访 计划。作为 CC，RTI 将提供科学专业知识和后勤支持，以创建有凝聚力的研究 该小组将开发证据基础，以增加 CRC 筛查、诊断和转诊护理 目前筛查率较低的人群。具体来说，我们将（1）提高生产力 ACCSIS 计划成员和利益相关者提供必要的后勤、通讯和服务 运营支持； (2) 支持多层次干预的证据基础的生成，以增加 通过建立通用数据元素和统一的数据收集程序来进行 CRC 筛查 研究项目； (3) 确定并支持本地开发的创新方法，以加速 评估其他有希望的干预措施以增加结直肠癌筛查； (4) 生成一个用户友好的 数据存储库并传播计划结果，以促进成功的方案的调整和推广 干预措施。 RTI 具有可以提高该计划的科学生产力的特定优势，包括 以下六种。 (1) 我们将根据我们的经验，使用之前测试过的程序和政策 CC 用于超过 35 个多地点项目，以加强 ACCSIS 研究之间的协调。 (2) 我们的团队，领导 由 Sujha Subramanian 博士设计，在 CRC 筛查研究方面拥有十多年的经验，并将 由实施科学、卫生系统和社区领域的多学科专家团队提供支持 临床联系、健康差异、多站点数据收集、生物统计学、伦理和健康数据法规， 网页设计、数据存储库管理和传播。 （三）完善现有框架 我们通过与 40 多家 CRC 合作开发的通用数据收集 通过扩大框架以纳入主持人和调解员来实施方案。扩建将 使我们能够了解干预各个层面（患者、提供者和 组织或社区）。 (4) 我们将利用我们现成的 CRC 利益相关者网络来 吸收从先前实施研究中吸取的经验教训，并确定本地开发的创新 接近。 (5) 我们将利用内部专业知识实施科学方法并进行混合 使用定量和定性数据进行分析，以对交叉点进行全面评估 多层次干预的现场调查结果。 (6) 我们将结合我们在通信科学领域的领导地位 与我们屡获殊荣的多媒体团队合作提供基于证据的品牌战略， 传播计划，以提高 ACCSIS 计划的知名度和影响力。

PROJECT SUMMARY/ABSTRACT To advance research in colorectal cancer (CRC) screening in support of the goals of the Beau Biden Cancer MoonshotSM Initiative, RTI International proposes to serve as the Coordinating Center (CC) for the Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program. As the CC, RTI will provide scientific expertise and logistical support to create a cohesive research group that will develop the evidence base to increase CRC screening, diagnosis, and referral-to-care among populations who currently have low rates of screening. Specifically, we will (1) enhance productivity of ACCSIS Program members and stakeholders by providing necessary logistical, communications, and operational support; (2) support the generation of the evidence base on multilevel interventions to increase CRC screening by establishing common data elements and harmonized data collection procedures across research projects; (3) identify and support locally-developed innovative approaches to accelerate the evaluation of additional promising interventions to increase CRC screening; and (4) generate a user-friendly data repository and disseminate program findings to facilitate the adaption and scale-up of successful interventions. RTI has specific strengths that will enhance the scientific productivity of the program, including the following six. (1) We will use previously tested procedures and policies, based on our experience as the CC for more than 35 multisite projects, to enhance coordination among ACCSIS studies. (2) Our team, led by Dr. Sujha Subramanian, has more than a decade of experience in CRC screening studies, and will be supported by a multidisciplinary team of experts in implementation science, heath systems and community clinical linkages, heath disparities, multisite data collection, biostatistics, ethics and health data regulations, web design, data repository management, and dissemination. (3) We will enhance existing frameworks for common data collection that we have developed through our partnership with more than 40 CRC implementation programs by expanding the frameworks to include moderators and mediators. Expansion will allow us to understand the underlying pathways at each level of the intervention (patient, provider, and organization or community). (4) We will draw upon our ready-built network of CRC stakeholders to incorporate lessons learned from prior implementation studies and to identify locally-developed innovative approaches. (5) We will leverage internal expertise in implementation science methods and conduct mixed analysis using both quantitative and qualitative data to perform a comprehensive assessment of the cross- site findings from the multilevel interventions. (6) We will combine our leadership in communication science methods with our award-winning multimedia team to deliver an evidence-based branding strategy and dissemination plan to increase the visibility and reach of the ACCSIS Program.