Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program

项目摘要/摘要 推进结直肠癌筛查研究以支持博拜登癌症的目标 MoonhotSM倡议，RTI International建议作为 通过实施科学促进结直肠癌筛查和随访(ACCSIS) 程序。作为CC，RTI将提供科学专业知识和后勤支持，以创建具有凝聚力的研究 将开发证据基础以增加结直肠癌筛查、诊断和转诊到护理的小组 目前筛查率较低的人群。具体地说，我们会(1)提高生产力 ACCSIS计划成员和利益相关者通过提供必要的后勤、通信和 业务支助；(2)支持建立多层次干预的证据基础，以增加 通过建立共同的数据元素和统一的数据收集程序进行CRC筛查 研究项目；(3)确定和支持当地开发的创新方法，以加快 评估其他有希望的干预措施，以增加结直肠癌筛查；和(4)产生便于用户使用的 数据存储和传播计划结果，以促进Success的适应和扩展 干预措施。RTI具有特定的优势，将提高该计划的科学生产率，包括 以下六个。(1)我们将使用之前经过测试的程序和政策，基于我们作为 CC用于35个以上的多站点项目，以加强ACCSIS研究之间的协调。(2)我们的团队，领衔 Sujha Subramanian博士在CRC筛查研究方面拥有十多年的经验，并将 由实施科学、卫生系统和社区方面的多学科专家团队提供支持 临床联系，健康差异，多点数据收集，生物统计学，伦理和健康数据法规， 网页设计、数据仓库管理和传播。(3)我们将加强现有的框架，以 我们通过与40多个CRC的合作伙伴关系开发的通用数据收集 通过扩大框架，将主持人和调解人包括在内，实施方案。扩张将 使我们能够了解干预的每个级别(患者、提供者和 组织或社区)。(4)我们将利用现有的启联利益相关者网络 吸收从以前的实施研究中吸取的经验教训，并确定当地开发的创新 接近了。(5)我们将利用实施科学方法方面的内部专业知识，开展混合 使用定量和定性数据进行分析，以执行交叉的全面评估 多层次干预的现场调查结果。(6)我们将把我们在通信科学方面的领导结合起来 与我们屡获殊荣的多媒体团队合作，提供基于证据的品牌战略和 传播计划，以提高ACCSIS计划的知名度和覆盖面。

PROJECT SUMMARY/ABSTRACT To advance research in colorectal cancer (CRC) screening in support of the goals of the Beau Biden Cancer MoonshotSM Initiative, RTI International proposes to serve as the Coordinating Center (CC) for the Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program. As the CC, RTI will provide scientific expertise and logistical support to create a cohesive research group that will develop the evidence base to increase CRC screening, diagnosis, and referral-to-care among populations who currently have low rates of screening. Specifically, we will (1) enhance productivity of ACCSIS Program members and stakeholders by providing necessary logistical, communications, and operational support; (2) support the generation of the evidence base on multilevel interventions to increase CRC screening by establishing common data elements and harmonized data collection procedures across research projects; (3) identify and support locally-developed innovative approaches to accelerate the evaluation of additional promising interventions to increase CRC screening; and (4) generate a user-friendly data repository and disseminate program findings to facilitate the adaption and scale-up of successful interventions. RTI has specific strengths that will enhance the scientific productivity of the program, including the following six. (1) We will use previously tested procedures and policies, based on our experience as the CC for more than 35 multisite projects, to enhance coordination among ACCSIS studies. (2) Our team, led by Dr. Sujha Subramanian, has more than a decade of experience in CRC screening studies, and will be supported by a multidisciplinary team of experts in implementation science, heath systems and community clinical linkages, heath disparities, multisite data collection, biostatistics, ethics and health data regulations, web design, data repository management, and dissemination. (3) We will enhance existing frameworks for common data collection that we have developed through our partnership with more than 40 CRC implementation programs by expanding the frameworks to include moderators and mediators. Expansion will allow us to understand the underlying pathways at each level of the intervention (patient, provider, and organization or community). (4) We will draw upon our ready-built network of CRC stakeholders to incorporate lessons learned from prior implementation studies and to identify locally-developed innovative approaches. (5) We will leverage internal expertise in implementation science methods and conduct mixed analysis using both quantitative and qualitative data to perform a comprehensive assessment of the cross- site findings from the multilevel interventions. (6) We will combine our leadership in communication science methods with our award-winning multimedia team to deliver an evidence-based branding strategy and dissemination plan to increase the visibility and reach of the ACCSIS Program.