Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program

项目概要/摘要 推进结直肠癌（CRC）筛查研究，以支持Beau Biden Cancer MoonshotSM倡议，RTI国际建议作为协调中心（CC）， 通过实施科学加速结直肠癌筛查和随访（ACCSIS） 程序.作为CC，RTI将提供科学专业知识和后勤支持，以创建一个有凝聚力的研究 该小组将开发证据基础，以增加CRC筛查，诊断和患者到护理， 目前筛查率较低的人群。具体而言，我们将（1）提高 ACCSIS计划成员和利益相关者，提供必要的后勤，通信， 业务支持;（2）支持建立多层次干预措施的证据库， 通过建立通用数据元素和统一的数据收集程序进行CRC筛查 （3）确定和支持当地开发的创新方法，以加快 评估其他有希望的干预措施，以增加CRC筛查;（4）生成用户友好的 数据储存库和传播方案结果，以促进适应和扩大成功的 干预措施。RTI具有特定的优势，将提高该计划的科学生产力，包括 以下六个。(1)我们将使用以前测试过的程序和政策，根据我们的经验， 为超过35个多地点项目提供协调中心，以加强ACCSIS研究之间的协调。(2)我们的团队， Sujha Subramanian博士在CRC筛查研究方面拥有十多年的经验， 由执行科学、卫生系统和社区的多学科专家小组提供支持 临床联系、健康差异、多地点数据收集、生物统计、伦理和健康数据法规， 网页设计、数据储存库管理和传播。(3)我们将加强现有框架， 我们通过与40多个CRC合作开发的通用数据收集 通过扩大框架以包括主持人和调解人来实施方案。扩张将 使我们能够了解每个干预水平（患者、提供者和 组织或社区）。(4)我们将利用我们已经建立的CRC利益相关者网络， 吸收从以前执行情况研究中吸取的经验教训， 接近。(5)我们将利用内部专业知识，实施科学方法， 使用定量和定性数据进行分析，以全面评估交叉- 多层次干预的现场调查结果。(6)我们将联合收割机在通信科学领域的领导地位 方法与我们屡获殊荣的多媒体团队，以提供基于证据的品牌战略， 传播计划，以提高ACCSIS方案的知名度和影响范围。

PROJECT SUMMARY/ABSTRACT To advance research in colorectal cancer (CRC) screening in support of the goals of the Beau Biden Cancer MoonshotSM Initiative, RTI International proposes to serve as the Coordinating Center (CC) for the Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program. As the CC, RTI will provide scientific expertise and logistical support to create a cohesive research group that will develop the evidence base to increase CRC screening, diagnosis, and referral-to-care among populations who currently have low rates of screening. Specifically, we will (1) enhance productivity of ACCSIS Program members and stakeholders by providing necessary logistical, communications, and operational support; (2) support the generation of the evidence base on multilevel interventions to increase CRC screening by establishing common data elements and harmonized data collection procedures across research projects; (3) identify and support locally-developed innovative approaches to accelerate the evaluation of additional promising interventions to increase CRC screening; and (4) generate a user-friendly data repository and disseminate program findings to facilitate the adaption and scale-up of successful interventions. RTI has specific strengths that will enhance the scientific productivity of the program, including the following six. (1) We will use previously tested procedures and policies, based on our experience as the CC for more than 35 multisite projects, to enhance coordination among ACCSIS studies. (2) Our team, led by Dr. Sujha Subramanian, has more than a decade of experience in CRC screening studies, and will be supported by a multidisciplinary team of experts in implementation science, heath systems and community clinical linkages, heath disparities, multisite data collection, biostatistics, ethics and health data regulations, web design, data repository management, and dissemination. (3) We will enhance existing frameworks for common data collection that we have developed through our partnership with more than 40 CRC implementation programs by expanding the frameworks to include moderators and mediators. Expansion will allow us to understand the underlying pathways at each level of the intervention (patient, provider, and organization or community). (4) We will draw upon our ready-built network of CRC stakeholders to incorporate lessons learned from prior implementation studies and to identify locally-developed innovative approaches. (5) We will leverage internal expertise in implementation science methods and conduct mixed analysis using both quantitative and qualitative data to perform a comprehensive assessment of the cross- site findings from the multilevel interventions. (6) We will combine our leadership in communication science methods with our award-winning multimedia team to deliver an evidence-based branding strategy and dissemination plan to increase the visibility and reach of the ACCSIS Program.