Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia trachomatis Infection

沙眼衣原体感染以患者为导向的研究职业生涯中期指导奖

• 批准号: 9164066
• 负责人: WILLIAM M GEISLER
• 金额: $ 13.13万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9164066
• 关键词: 9 year old; Accident and Emergency department; Address; Adolescent and Young Adult; African American; Age; Alabama; American; Antibiotics; Antibodies; Antibody Response; Area; Award; Book Chapters; Characteristics; Chlamydia; Chlamydia trachomatis; Clinic; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Conduct Clinical Trials; Detection; Development Plans; Doctor of Medicine; Dysuria; Enrollment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Faculty; Fellowship Program; Female; Female Adolescents; Frequencies; Funding; Genital system; Genitourinary system; Goals; Grant; Guidelines; Health; Human; Infection; Infection Control; Infertility; Internal Medicine; Interview; Knowledge; Lead; Manuscripts; Master of Public Health; Medical; Medicine; Mentors; Nitrites; Pathway interactions; Patients; Persons; Physicians; Population; Pregnancy Outcome; Prevention; Primary Health Care; Provider; Publishing; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Scientist; Serum; Sexual Partners; Sexually Transmitted Diseases; Source; Staging; Testing; Training; Training Programs; Translational Research; Universities; Urinary tract infection; Urine; Work; adolescent health; career; clinical care; effective therapy; experience; improved; ineffective therapies; interest; novel; patient oriented research; patient population; programs; reproductive morbidity; research study; screening; sexually active; skills; tool; treatment strategy; university student; urinary

William M. Geisler, M.D., M.P.H., is a mid-career stage physician scientist at the University of Alabama at Birmingham (UAB) with independent federal funding, expertise in Chlamydia trachomatis (CT) infections, and significant experience in mentoring early career stage trainees in patient-oriented research (POR). This midcareer investigator award would enable Dr. Geisler to: 1) further develop his mentoring skills, 2) continue providing POR mentoring to early career stage trainees, and 3) expand his research program in new directions by supporting two new research projects. CT infections are highly prevalent in young females (adolescents and young adults) and can cause significant reproductive morbidity when untreated. Since the majority of CT infections are asymptomatic, they are often unrecognized and may go untreated. CT detection relies in large part on screening young females annually. Because provider compliance with CT screening is low and screening at an annual interval misses many infections that resolve spontaneously or are incidentally treated, the cumulative burden of CT infection in asymptomatic young females is unknown. Another missed opportunity for treating CT infection is in females with CT-associated dysuria who are misdiagnosed with a urinary tract infection (UTI), often prescribed UTI treatment ineffective against CT, and usually not tested for CT. With award support, Dr. Geisler plans to expand and refine his mentoring skills through didactics and training, and to continue mentoring his current early stage trainees and recruit new trainees through multiple UAB sources. All trainees will be provided with educational and research experiences tailored to their career stage and interests. With award support, Dr. Geisler’s research program will be augmented through two new studies addressing missed opportunites for CT detection and treatment, which will provide new opportunities for mentoring trainees, collaborations, and funding. The Aim of New Study 1 is: Evaluate the cumulative burden of CT infection in female adolescents and young adults and predictors of higher burden. Females ages 16-29 years will be enrolled at 4 UAB clinics with different patient populations. Subjects will be interviewed and undergo urine CT testing and serum CT antibody testing. Cumulative burden of CT infection represents positivity by either test. The Aim of New Study 2 is: Determine the frequency of CT infection in female adolescents and young adults presenting with dysuria and the patient and urine characteristics that distinguish CT infection from UTI. Females ages 16-29 years presenting to the UAB Emergency Department with dysuria will be enrolled, interviewed, undergo urogenital CT testing, and have a urine dipstick and bacterial culture performed. The long-term goal of Dr. Geisler’s research is to improve prevention and control of CT infection. Knowledge from the new studies could lead to improve CT screening strategies in young asymptomatic females and more testing and treatment in females presenting with CT-associated dysuria. The research studies will provide mentoring opportunities in POR for multiple early stage trainees.

William M. Geisler，医学博士、公共卫生硕士，是阿拉巴马大学的一名职业中期医师科学家。 伯明翰 (UAB) 拥有独立的联邦资助、沙眼衣原体 (CT) 感染方面的专业知识，以及 在指导早期职业阶段学员进行以患者为导向的研究（POR）方面拥有丰富的经验。这 职业生涯中期研究员奖将使盖斯勒博士能够：1）进一步发展他的指导技能，2）继续 为早期职业阶段的学员提供 POR 指导，以及 3) 将他的研究项目扩展到新的方向 通过支持两个新的研究项目。 CT 感染在年轻女性（青少年和青少年）中非常普遍。 年轻人），如果不及时治疗，可能会导致严重的生殖疾病。由于大多数CT 感染是无症状的，往往未被识别，也可能得不到治疗。 CT检测依赖于大 每年对年轻女性进行筛查。因为提供者对 CT 筛查的依从性较低，而且 每年一次的筛查会漏掉许多自发消退或偶然治疗的感染， 无症状年轻女性中 CT 感染的累积负担尚不清楚。又一个错失的机会 用于治疗 CT 感染，适用于患有 CT 相关排尿困难且被误诊为泌尿道疾病的女性 感染（UTI），通常规定 UTI 治疗对 CT 无效，并且通常不进行 CT 检查。 在奖项的支持下，盖斯勒博士计划通过教学和实践来扩展和完善他的指导技能。 培训，并继续指导目前的早期学员并通过多种方式招募新学员 UAB 来源。所有学员都将获得适合其职业生涯的教育和研究经验 阶段和兴趣。在奖项的支持下，盖斯勒博士的研究计划将通过两项新的研究得到加强 针对 CT 检测和治疗错失机会的研究，这将提供新的机会 用于指导学员、合作和资助。新研究 1 的目的是：评估累积的 女性青少年和年轻人的 CT 感染负担以及较高负担的预测因素。女性年龄 16-29岁的患者将在4个UAB诊所招募不同的患者群体。受试者将接受采访并 进行尿液CT检测和血清CT抗体检测。 CT感染的累积负担代表 任一测试呈阳性。新研究 2 的目的是：确定女性 CT 感染频率 出现排尿困难的青少年和年轻人以及区分的患者和尿液特征 尿路感染 CT 感染。因排尿困难而到 UAB 急诊科就诊的 16-29 岁女性 将被登记、面试、接受泌尿生殖 CT 检测、并进行尿液试纸和细菌培养 执行。 Geisler 博士研究的长期目标是改善 CT 感染的预防和控制。 新研究中的知识可能有助于改善年轻无症状患者的 CT 筛查策略 女性，并对出现 CT 相关排尿困难的女性进行更多检查和治疗。研究 研究将为多个早期阶段的学员提供 POR 方面的指导机会。