Stress Effects on Virus Protein induced Inflammation and Sickness Behavior

 描述（由申请人提供）：我们已经鉴定了一类新的病原体相关分子模式（PAMP）蛋白（脱氧尿苷三磷酸核苷酸水解酶; dUTPases），其具有新的免疫调节和神经调节功能，可能有助于人类疱疹病毒引起的疾病的病理生理学。使用EB病毒（EBV）-dUTR作为原型，我们的开创性研究已经最终证明EBV-dUTR诱导疾病和焦虑行为以及独立于其酶活性的受损学习/记忆效应。此外，应力增强了EBV-dUTR的性质。这项多学科研究资助将提供有关压力影响EBV-dUTR介导效应的机制的新信息，因为它与慢性疲劳综合征有关。

 DESCRIPTION (provided by applicant): We have identified a new class of pathogen-associated molecular pattern (PAMP) proteins (deoxyuridine triphosphate nucleotidohydrolases; dUTPases) that have novel immunoregulatory and neuroregulatory functions that may contribute to the pathophysiology of diseases caused by human herpesviruses. Using the Epstein-Barr virus (EBV)- dUTPase as the prototype, our pioneering studies have demonstrated conclusively that the EBV-dUTPase induces sickness and anxiety behavior and impaired learning/memory effects independent of its enzymatic activity. Furthermore, the properties of the EBV- dUTPase were enhanced by stress. This multidisciplinary research grant will provide new information on the mechanism by which stress can impact the EBV-dUTPase-mediated effects as it relates to chronic fatigue syndrome.