Risk and Protective Factors for Adherence to Pre-Exposure Prophylaxis (PrEP) in Transwomen of Color
有色变性女性坚持暴露前预防 (PrEP) 的风险和保护因素
基本信息
- 批准号:9347219
- 负责人:
- 金额:$ 23.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-05-01 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAIDS/HIV problemAddressAdherenceAlcohol or Other Drugs useAnti-Retroviral AgentsAttenuatedBehavior TherapyBirthCaliforniaClinicalClinical ResearchColorCoping SkillsDataDevelopmentDiscriminationDrug CombinationsEffectivenessEmotionalEnrollmentEquationEthnic OriginEventFemaleFundingFutureGenderGender IdentityGrantHIVHIV InfectionsHIV SeropositivityHIV riskHormonesIndividualInterventionInterviewInvestigationLifeLife ExperienceMeasuresMental HealthMethodsMinorityModelingNational Institute of Drug AbusePersonsPilot ProjectsPopulationPreventionPrevention strategyPublic HealthRaceReportingResearchResearch MethodologyResearch PersonnelResistance developmentResourcesRiskRisk BehaviorsRoleSamplingSocial supportStressSubstance Use DisorderSubstance abuse problemTenofovirTestingTimeTraumaTreatment FailureUnited StatesVictimizationWomanalcohol abstinencebasecisgendercopingemtricitabineethnic diversityethnic minority populationexperiencehigh riskhigh risk populationimprovedmalemen who have sex with menpre-exposure prophylaxispreventprogramsracial and ethnicracial diversityresiliencesex riskstress resiliencetherapy developmenttransgendertransgender womentransmission processtransphobiatreatment adherence
项目摘要
Project Abstract
Transgender women (TW) are currently the SGM population at highest risk for HIV infection in the United
States, especially those who are racial/ethnic minorities. TW also report the highest levels of discrimination,
victimization, traumatic life events, and other stressful experiences and are of the highest risk groups for
substance abuse and mental health problems. HIV researchers have suggested resiliency may be a largely
untapped resource in behavioral interventions and that it may be associated with reductions in mental health
problems, substance abuse, and HIV related risk among marginalized populations. Daily pre-exposure
prophylaxis (PrEP) is extremely effective in preventing HIV infection among those who are HIV-negative. While
this is an exciting development for HIV prevention among minority TW, HIV prevention efforts must now shift
focus to research on optimizing PrEP adherence among this high-risk population facing multiple recurring
stressful life events and numerous structural barriers. In the proposed study, we will leverage an ongoing study
of (N =300) racially and ethnically diverse TW enrolled in the Southern California based PrEP demonstration
project, in order to conduct mixed-methods research, first using structural equation modeling (SEM) to
assessing the risk and resiliency factors most associated with PrEP adherence among TW. Then using the
SEM findings to inform follow-on, in-depth qualitative interviews with a sub-sample of high- to low-adherence
minority TW to further explore those risk and resiliency factors and experiences most salient to PrEP
adherence among high-risk minority TW. This study will provide the preliminary data to support the submission
of an intervention development grant (NIDA R34) to develop a resilience-based intervention focused on
improving PrEP adherence for TW.
项目摘要
跨性别妇女(TW)目前是美国艾滋病毒感染风险最高的SGM人群。
国家,特别是那些种族/族裔少数群体。TW还报告了最严重的歧视,
受害,创伤性生活事件和其他压力经历,是最高风险群体,
药物滥用和精神健康问题。艾滋病研究人员表示,弹性可能在很大程度上是
在行为干预方面尚未开发的资源,它可能与心理健康的减少有关。
边缘化人群中的问题、药物滥用和艾滋病毒相关风险。每日预暴露
预防性治疗(PrEP)在预防HIV阴性者感染HIV方面非常有效。而
这是TW少数民族艾滋病预防的一个令人兴奋的发展,艾滋病预防工作现在必须转变
专注于研究在面临多次复发的高风险人群中优化PrEP依从性
压力生活事件和许多结构性障碍。在拟议的研究中,我们将利用正在进行的研究
在南加州PrEP示范中招募的种族和民族多样的TW(N = 300)
项目,为了进行混合方法的研究,首先使用结构方程模型(SEM),
评估与TW之间PrEP依从性最相关的风险和弹性因素。然后使用
SEM调查结果为后续深入的定性访谈提供信息,其中包含高依从性至低依从性的子样本
少数TW进一步探索那些风险和弹性因素和经验最突出的准备
高风险少数TW之间的依从性。本研究将提供初步数据以支持提交
一项干预发展赠款(NIDA R34),用于制定一项基于依从性的干预措施,重点是
改善TW的PrEP依从性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Erik D. Storholm其他文献
The Effect of Behavioral Regulation on Condomless Anal Sex Among Young Sexual Minority Men: Influences of Sex-Related Substance Use, Partnership Type, and PrEP Use
- DOI:
10.1007/s10461-025-04753-4 - 发表时间:
2025-05-29 - 期刊:
- 影响因子:2.400
- 作者:
Stephen D. Ramos;Bryce F. Stamp;Kimberly A. Powers;Lisa Hightow-Weidman;Erik D. Storholm;Zachary R. Soberano;Jacob B. Stocks;Matthew T. Rosso;Keith J. Horvath - 通讯作者:
Keith J. Horvath
Cigarette Smoking as Part of a Syndemic among Young Men Who Have Sex with Men Ages 13–29 in New York City
吸烟是纽约市 13 至 29 岁男男性行为者中一种流行病
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Erik D. Storholm;P. Halkitis;Daniel E Siconolfi;Robert W. Moeller - 通讯作者:
Robert W. Moeller
Preliminary Outcomes from PrEP Well: A Community-led, Multicomponent HIV Prevention Strategy Implemented in a Transgender Community Health Center
- DOI:
10.1007/s10900-025-01468-4 - 发表时间:
2025-04-21 - 期刊:
- 影响因子:2.200
- 作者:
Erik D. Storholm;Carrie L. Nacht;Chloe Opalo;Risa Flynn;Kimberly Ling Murtaugh;Mariana Marroquin;Mika Baumgardner;Alex R. Dopp - 通讯作者:
Alex R. Dopp
LAI-ART Awareness, Willingness, Barriers and Facilitators among Black Sexual Minority Men Living with HIV in the US South
美国南部感染艾滋病毒的黑人性少数男性的 LAI-ART 意识、意愿、障碍和促进因素
- DOI:
10.3390/ijerph21050602 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Chadwick K Campbell;Kirstin Kielhold;Hannah E. Reynolds;Wilson Vincent;Daniel E Siconolfi;Stephen D. Ramos;Adedotun Ogunbajo;S. Kegeles;Erik D. Storholm - 通讯作者:
Erik D. Storholm
Differential Associations of Depressive Symptomology to HIV Care Engagement Among Young Black Sexual Minority Men with HIV (YBSMM+) in the US South: A Multi-Group Analysis of Mood, Intimate Partner Violence, and Alcohol Use
- DOI:
10.1007/s10461-023-04186-x - 发表时间:
2023-10-05 - 期刊:
- 影响因子:2.400
- 作者:
Stephen D. Ramos;Wilson Vincent;Daniel E. Siconolfi;Lance M. Pollack;Keith J. Horvath;Chadwick K. Campbell;Scott Tebbetts;Susan M. Kegeles;Erik D. Storholm - 通讯作者:
Erik D. Storholm
Erik D. Storholm的其他文献
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{{ truncateString('Erik D. Storholm', 18)}}的其他基金
Intimate Partner Violence and HIV Prevention Continuum Engagement Among Transgender and Nonbinary Populations
跨性别和非二元人群中的亲密伴侣暴力和艾滋病毒预防持续参与
- 批准号:
10762298 - 财政年份:2023
- 资助金额:
$ 23.13万 - 项目类别:
Investigating the Impact of Substance Use, Intimate Partner Violence, and COVID-19 on HIV Care Engagement among Young Black Sexual Minority Men with HIV in the US South
调查药物使用、亲密伴侣暴力和 COVID-19 对美国南部感染艾滋病毒的年轻黑人性少数男性的艾滋病毒护理参与度的影响
- 批准号:
10431827 - 财政年份:2021
- 资助金额:
$ 23.13万 - 项目类别:
Intimate Partner Violence and HIV Prevention among Sexual Minority Men
性少数男性的亲密伴侣暴力和艾滋病毒预防
- 批准号:
10556404 - 财政年份:2021
- 资助金额:
$ 23.13万 - 项目类别:
Investigating the Impact of Substance Use, Intimate Partner Violence, and COVID-19 on HIV Care Engagement among Young Black Sexual Minority Men with HIV in the US South
调查药物使用、亲密伴侣暴力和 COVID-19 对美国南部感染艾滋病毒的年轻黑人性少数男性的艾滋病毒护理参与度的影响
- 批准号:
10161009 - 财政年份:2021
- 资助金额:
$ 23.13万 - 项目类别:
Intimate Partner Violence and HIV Prevention among Sexual Minority Men
性少数男性的亲密伴侣暴力和艾滋病毒预防
- 批准号:
10254507 - 财政年份:2021
- 资助金额:
$ 23.13万 - 项目类别:
Intimate Partner Violence and HIV Prevention among Sexual Minority Men
性少数男性的亲密伴侣暴力和艾滋病毒预防
- 批准号:
10378715 - 财政年份:2021
- 资助金额:
$ 23.13万 - 项目类别:














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