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A Study of Pulmonary Congestion and Patient-reported Outcomes in Heart Failure (MONITOR - HF)

心力衰竭肺充血和患者报告结果的研究 (MONITOR - HF)

基本信息

批准号：
9345360
负责人：
Jonathan Patrick Auld
金额：
$ 4.01万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9345360
关键词：
Address Admission activity Adult Affect Behavior Behavioral Biological Biological Markers Biology Cardiac Cardiac health Cardiopulmonary Cardiovascular Diseases Clinical Clinical Management Congestive Congestive Heart Failure Data Defibrillators Development Devices Diagnosis Distress Dyspnea EFRAC Edema Elderly Fatigue Fellowship Foundations Frequencies Functional disorder Goals Heart failure Hospitalization Hospitals Implant In Situ Incidence Influentials Interdisciplinary Study Intervention Knowledge Link Lung Measures Mission Modeling Monitor Morbidity - disease rate National Institute of Nursing Research National Research Service Awards Nurses Pacemakers Patient Outcomes Assessments Patient-Focused Outcomes Patients Prevalence Quality of life Research Proposals Research Training Role Scientist Self Care Self Management Signs and Symptoms Surveys Symptoms Technology Testing Time Training United States Weight Gain Work base behavior influence clinically significant cohort experience health related quality of life heart function hemodynamics improved improved outcome innovation insight longitudinal design mortality physical conditioning physical symptom pressure prevent programs symptom management symptom self management treatment adherence

项目摘要

Project Summary Heart failure (HF) is the fastest growing cardiovascular disorder in the United States and continues to be associated with high morbidity and mortality. Recognition of symptoms is a critical factor in the diagnosis and treatment of HF because symptoms are key drivers of hospitalizations and health-related quality of life (HRQOL). Our ability to predict who will experience more burdensome symptoms is hindered by the lack of association between objective markers of heart function and symptoms. A critical gap in our knowledge of HF symptom biology is how pulmonary congestion, an objective measure of HF pathophysiology, is related to HF symptoms, self-management behaviors and HRQOL. Accordingly, the overall goals of this study is to determine the association of pulmonary congestion that is detected by devices used in the clinical management of HF with physical symptoms of HF and HRQOL and to examine the role of self-management in moderating the relationship between device-detected congestion, symptoms and quality of life. Employing a longitudinal design and integrating data remotely downloaded from implanted defibrillator/pacemakers and data collected via survey in a cohort of 60 adults with symptomatic HF, we will address two specific aims: 1) quantify the association between device-detected congestion with both HF symptoms and HRQOL and 2) determine the influence of HF self-care management on the relationship between device-detected congestion and HF symptoms and HRQOL. This innovative study will be the first to examine associations between pulmonary congestion and physical HF symptoms and the first to determine the role of patient self-care management in moderating the relationship between device-detected congestion, HRQOL and symptoms of HF. Furthermore, as a research proposal supported by a National Research Service Award, this study will contribute to the development of the applicant into an independent nurse scientist with an influential program of study focusing on biological and behavioral foundations of HF symptoms. The proposed study and training plan integrate the combined clinical and analytic expertise of a well-established interdisciplinary team. This proposed fellowship research and training plan is well-aligned with the mission and goals of National Institute of Nursing Research through the focus on symptom biology, self-management behaviors, and the development of influential and independent nurse scientists.

项目摘要心力衰竭（HF）是美国增长最快的心血管疾病，与高发病率和死亡率相关。识别症状是诊断的关键因素，治疗HF，因为症状是住院和健康相关生活质量的关键驱动因素（HRQOL）。我们预测谁将经历更多负担症状的能力受到缺乏心功能客观指标与症状之间的相关性。我们对HF的认识存在一个关键的空白症状生物学是指肺充血（HF病理生理学的客观指标）与HF之间的关系症状、自我管理行为和HRQOL。因此，本研究的总体目标是确定临床中使用的设备检测到的肺充血的关联管理HF与HF的身体症状和HRQOL，并检查自我管理的作用，调节设备检测到的充血、症状和生活质量之间的关系。采用纵向设计和整合从植入式除颤器/起搏器远程下载的数据，通过对60例有症状HF成人队列的调查收集的数据，我们将解决两个具体目标：1）量化设备检测到的充血与HF症状和HRQOL之间的关联，以及2）确定HF自助管理对设备检测到的拥塞之间的关系的影响 HF症状和HRQOL。这项创新的研究将是第一个研究之间的联系，肺充血和HF的躯体症状及首先判断患者自我护理的作用管理在缓和设备检测到的充血，HRQOL和症状之间的关系， HF。此外，作为国家研究服务奖支持的研究提案，本研究将有助于申请人发展成为一个独立的护士科学家与一个有影响力的计划，研究重点是HF症状的生物学和行为学基础。拟议的学习和培训计划整合了一个成熟的跨学科团队的临床和分析专业知识。这拟议的奖学金研究和培训计划与国家研究所的使命和目标完全一致通过关注症状生物学、自我管理行为和发展来进行护理研究有影响力的独立护士科学家