Physical Activity Lifestyle Intervention for Emerging Adults with Congenital Heart Disease

项目摘要/摘要 杰米·L·杰克逊博士是美国国家生物行为健康中心助理教授 儿童医院和俄亥俄州立大学。她的职业目标是成为一名独立的临床医生-科学家 具有开发和实施随机行为临床试验的专业知识，以提高自我 先天性心脏病(CHD)过渡年龄存活者的管理。杰克逊博士收到了一台K23 研究体力活动(PA)干预的可行性和初步效果的奖项 CHD青少年中的中度到剧烈的PA参与度。随着冠心病幸存者进入成年期，他们 患获得性心血管并发症的风险更高，如高血压、冠心病 动脉疾病和心力衰竭。这些合并症容易受到生活方式变化的影响，例如增加 爸。在美国，新发成年冠心病患者的PA发生率相对未知，但总体上 在刚成年的时候，人口会下降。因此，为了成功地进行获得性疾病的一级预防 日益增长的老年冠心病幸存者的心血管并发症，青春期和 成年初期可能是健康行为干预的最佳发展阶段。vt.给出 成年初期是一个独特的发展阶段，PA干预的可行性不能 假设，并且必须通过经验来确定。为NHLBI K受助人建议的小额助学金计划 (R03)旨在1)评估同样的PA干预作为杰克逊博士的一部分进行的可行性 在新出现的成年冠心病幸存者中获得K23奖，以及2)从参与者那里获得关于 干预会议的内容和使用焦点小组进行研究的程序。参与者将包括30人 患有严重冠心病的新兴成人(年龄19-25岁)将被随机分配到2组中的1组：为期20周 视频会议-管理PA干预臂(8，30分钟会议；跟踪活动和设定目标 使用Fitbit®)或接受Fitbit的比较臂，但不与研究干预者接触。这个 计划行为理论是干预内容的基础，这样态度、规范信念和 将解决感知到的行为控制问题。被随机分配到干预组的参与者将被邀请 参加焦点小组，提供进一步的反馈。客观和自我报告的可行性措施将 收集数据，包括招聘率、参加干预课程的情况、保留率、评估 完成率和自我报告的干预经验。定性反馈将被录音， 转录，并编码。除了为杰克逊博士作为临床科学家的独立性做出贡献外， 目前的研究结果预计将增强该公司的竞争力，并为其程序提供信息 更大规模的R01研究，将确定有效性并确定这种干预在 处于过渡期的冠心病幸存者。

PROJECT SUMMARY/ABSTRACT Jamie L. Jackson, PhD, is an Assistant Professor in the Center for Biobehavioral Health at Nationwide Children’s Hospital and Ohio State University. Her career goal is to become an independent clinician-scientist with expertise in developing and implementing randomized behavioral clinical trials to improve self- management among transition-aged survivors of congenital heart disease (CHD). Dr. Jackson received a K23 award to examine the feasibility and preliminary efficacy of a physical activity (PA) intervention to increase moderate to vigorous PA engagement among adolescents with CHD. As CHD survivors enter adulthood, they have a greater risk for developing acquired cardiovascular complications, such as hypertension, coronary artery disease, and heart failure. These comorbidities are amenable to lifestyle changes, such as increasing PA. Rates of PA among emerging adults with CHD in the U.S. are relatively unknown, but rates in the general population decline during emerging adulthood. Therefore, for successful primary prevention of acquired cardiovascular complications in this growing population of aging CHD survivors, both adolescence and emerging adulthood may be optimal developmental stages to target for health behavior interventions. Given that emerging adulthood is a unique developmental stage, the feasibility of a PA intervention cannot be assumed and must be empirically determined. The proposed Small Grant Program for NHLBI K Recipients (R03) aims to 1) evaluate the feasibility of the same PA intervention being conducted as part of Dr. Jackson’s K23 award among emerging adult CHD survivors and 2) obtain qualitative feedback from participants on the content of the intervention sessions and study procedures using focus groups. Participants will include 30 emerging adults (ages 19-25) with critical CHD who will be randomized to 1 of 2 arms: a 20-week videoconferencing-administered PA intervention arm (8, 30 min sessions; tracking activity and setting goals using Fitbit®) or a comparison arm that receives a Fitbit, but has no contact with a study interventionist. The Theory of Planned Behavior underpins the intervention content such that attitudes, normative beliefs, and perceived behavioral control will be addressed. Participants randomized to the intervention arm will be invited to participate in a focus group to provide further feedback. Objective and self-report measures of feasibility will be collected, including recruitment rate, adherence to intervention sessions, retention rate, assessment completion rate, and self-report of the intervention experience. Qualitative feedback will be audio recorded, transcribed, and coded. In addition to contributing to Dr. Jackson’s independence as a clinician-scientist, the results of the current study are expected to enhance the competitiveness of and inform the procedures for a larger R01 study, which will establish efficacy and determine the long-term effects of this intervention among transition-aged CHD survivors.