How MERS-CoV Regulates Innate Immunity in Primary Human Lung Cells
How MERS-CoV Regulates Innate Immunity in Primary Human Lung Cells
批准号:
9809270
负责人:
AMY C SIMS
金额:
$19.44万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-05 至 2021-05-31
关键词:
AcetylationAntibodiesAntiviral AgentsArchitectureAreaBindingCell Culture TechniquesCell LineCellsChromatinChromatin StructureComplexConsensusCoronavirusCoronavirus InfectionsDNA MethylationDataData SetDevelopmentDisease OutcomeEmerging Communicable DiseasesEndothelial CellsEndotheliumEnzymesEpigenetic ProcessEpithelial CellsFibroblastsFoundationsFutureGene ExpressionGene Expression ProfileGene Expression RegulationGenesGoalsHistone DeacetylaseHistonesHumanIRF3 geneImmuneImmune responseInfectionInnate Immune ResponseInterferon-betaInterferonsKineticsLungMediatingMethodsMethylationMiddle East Respiratory Syndrome CoronavirusModelingModificationMolecularNatural ImmunityPathogenesisPathogenicityPathway interactionsPatternPlayPrimary InfectionProcessPromoter RegionsProteinsProteomicsPublic HealthRNAReadinessRoleSTAT1 geneSeverity of illnessTestingTherapeuticTissuesVaccinesViralViral GenesViral ProteinsVirusVirus DiseasesVirus Replicationbasecell typechromatin immunoprecipitationchromatin modificationchromatin remodelingcytokinedesigndifferential expressiondisease phenotypeepigenomehistone methylationhistone methyltransferaseimmune activationimprovedinhibitor/antagonistinsightnovelnovel strategiesnovel viruspathogenpreventprogramsrespiratoryrespiratory virusresponsetissue regenerationtissue repairtranscription factortranscriptomics
中文摘要
摘要
英文摘要
ABSTRACT
The molecular mechanisms regulating emerging highly pathogenic human respiratory
coronavirus pathogenesis are complex and include dampening of the host innate immune
response allowing higher viral titers immediately following entry. Previous studies tracking the
expression of interferon stimulated gene (ISG) expression in Middle East respiratory syndrome
coronavirus (MERS-CoV) infected continuous human lung epithelial cells demonstrated that
specific ISG expression patterns could be detected and these patterns could be used to
determine how CoV were modulating the innate immune response. Epigenetic/chromatin
remodeling mechanisms were found to be important regulators of host chromatin remodeling
that altered host expression ISG patterns. This proposal will build on these foundational studies
performed in continuous human lung cell lines and define ways that MERS-CoV regulates
innate immunity in primary human lung fibroblasts and microvascular endothelial cells.
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会议论文
How MERS-CoV Regulates Immunity in Human Lung Tissue
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批准号:10187973
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项目类别:
-
资助金额:$16.69万
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财政年份:2019
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负责人:AMY C SIMS
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依托单位:
Targeted Gene Expression from NL63 Vaccine Vectors
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批准号:8150234
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项目类别:
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资助金额:$8.37万
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财政年份:2010
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负责人:AMY C SIMS
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依托单位:
Human Coronaviruses as Multigene Mucosal Vaccine Vectors for HIV
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批准号:7495338
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项目类别:
-
资助金额:$22.85万
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财政年份:2008
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负责人:AMY C SIMS
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依托单位:
Targeted Gene Expression from NL63 Vaccine Vectors
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批准号:7640659
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项目类别:
-
资助金额:$18.5万
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财政年份:2008
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负责人:AMY C SIMS
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依托单位:
Targeted Gene Expression from NL63 Vaccine Vectors
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批准号:7509247
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项目类别:
-
资助金额:$22.13万
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财政年份:2008
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负责人:AMY C SIMS
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依托单位:
Human Coronaviruses as Multigene Mucosal Vaccine Vectors for HIV
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批准号:7629736
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项目类别:
-
资助金额:$19.25万
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财政年份:2008
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负责人:AMY C SIMS
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依托单位:
海外基金