Chronic Effects of Neurotrauma Consortium (CENC) Imaging Core

神经创伤联盟 (CENC) 影像核心的慢性影响

• 批准号: 9812778
• 负责人: Elisabeth A Wilde
• 金额: --
• 依托单位: MICHAEL E DEBAKEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9812778
• 关键词: Address; Advanced Development; Anatomy; Auditory; Autonomic Dysfunction; Basic Science; Behavioral; Biological Markers; Brain Concussion; Brain imaging; Chronic; Clinical; Cognitive; Collaborations; Collection; Communication; Comorbidity; Complex; Computer software; Data; Data Collection; Data Quality; Department of Defense; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Elderly; Ensure; Evaluation; Functional Magnetic Resonance Imaging; Funding; Future; Grant; Growth; Headache; Health; Human Resources; Image; Image Analysis; Imaging Techniques; Impairment; Individual; Information Technology; Knowledge; Link; Long-Term Effects; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Manuscripts; Medical center; Medicine; Memory; Methods; Mission; Molecular; Movement Disorders; Nature; Nerve Degeneration; Nervous System Trauma; Neurodegenerative Disorders; Neurologic; Neurons; Neuropsychology; Neurosciences; Neurosecretory Systems; Outcome; Pain; Participant; Patients; Personal Satisfaction; Physics; Physiologic pulse; Physiological; Preparation; Prevalence; Privatization; Prognostic Marker; Quality Control; Research; Research Institute; Research Personnel; Resources; Rest; Seizures; Sensory; Severities; Site; Sleep Disorders; Sorting - Cell Movement; Spin Labels; Structure; Supervision; Testing; Therapeutic; Thick; Training; Traumatic Brain Injury; Universities; Update; Veterans; Visual; Work; base; college; computer program; effective therapy; imaging biomarker; improved; mild traumatic brain injury; neuroimaging; novel; programs; psychologic; quality assurance; rehabilitation strategy; service member; statistics; treatment strategy

Project Background/Rationale: The mission of the Chronic Effects of Neurotrauma Consortium (CENC) is to fill gaps in knowledge about the basic science of concussion or mild traumatic brain injury (mTBI), determine its effects on late-life outcomes and neurodegeneration, identify Service Members most susceptible to these effects, and identify the most effective treatment strategies. The CENC is a multi-center collaboration linking premier basic science, translational, and clinical neuroscience researchers from the Department of Defense, VA, academic universities, and private research institutes to effectively address the scientific, diagnostic, and therapeutic ramifications of mTBI and its long-term effects. The Houston-based CENC Neuroimaging Core is comprised of an interdisciplinary team of neuroimaging experts from neuroradiology, neuropsychology, MR physics, information technology and computer programming, and statistics who facilitate sequence development and pulse programming, training and supervision of technologists, acquisition of imaging data, quality assurance, conventional and advanced imaging analysis, transfer and storage of imaging data, and assistance in interpreating neuroimaging data for existing and future Consortium projects. The Core is comprised of both VA- and academic-affiliate resources; an expansion of existing Core funds already granted to the academic affiliate (Baylor College of Medicine) is needed due to the Consortium's growth and the resulting change in the Core's scope of work. Specifically, expansion of the number of study sites for existing studies and the addition of several new projects has substantially increased the Core's responsibilities, including additional oversight, quality control, analysis, and administrative duties for Michael E. DeBakey VA Medical Center (MEDVAMC)-based Core investigators and staff. Project Objectives: Objectives of the Neuroimaging Core are to: 1) assist in the acquisition of brain imaging data, including conventional magnetic resonance imaging (MRI), detailed volumetry and cortical thickness, diffusion tensor imaging (DTI), arterial spin labeling (ASL), and resting state functional connectivity MRI (fcMRI); 2) transfer, convert, analyze, and store brain imaging data; 3) direct and assist in performing quality assurance of the scanners at all sites involved in imaging data collection; and 4) communicate with the investigators of projects involving imaging to facilitate integration of imaging data into the projects to address their aims. Project Methods: The collective expertise of the investigators in the Core facilitates utilization and analysis of several conventional and advanced imaging techniques. MEDVAMC-based Core personnel, including MR physicists, oversee quality assurance testing on each magnet, which is performed on a regular basis to ensure scanner accuracy, stability, and comparability. Core personnel assist in the pulse programming and sequence development for advanced MR sequences used in specific projects. Core investigators provide additional training to MR technologists and also to project coordinators on preparing participants to undergo imaging. Core personnel additionally provide assistance with computer programming to facilitate data sorting and analysis. Due to the complex nature of transferring and storing very large amounts of data as well as frequent software updates required by some imaging analysis programs, individuals with IT expertise are also involved. Core personnel also train and supervise all image analysts, assist in the interpretation of imaging data, and assist in manuscript preparation.

项目背景/基本原理：神经创伤慢性影响联合会(CENC)的使命是 填补脑震荡或轻度创伤性脑损伤(MTBI)基础科学知识的空白，确定其 对晚年结局和神经退化的影响，确定最容易受到这些影响的服役人员 效果，并确定最有效的治疗策略。CENC是一个多中心的协作链接 国防部优秀的基础科学、翻译和临床神经科学研究人员， 弗吉尼亚州、学术大学和私人研究机构，有效地解决科学、诊断和 重型颅脑损伤的治疗效果及其远期疗效。 总部设在休斯顿的CENC神经成像核心由一个跨学科的神经成像团队组成 来自神经放射学、神经心理学、磁共振物理学、信息技术和计算机的专家 编程，以及促进序列开发和脉冲编程、培训和 监督技术人员、获取成像数据、质量保证、常规和高级 成像数据的成像分析、传输和存储，并协助解释神经成像数据 现有和未来的财团项目。核心由退伍军人事务部和学术附属机构资源组成； 对已经授予学术附属机构(贝勒医学院)的现有核心资金的扩展是 由于财团的发展和由此导致的核心工作范围的变化，因此需要更多的人力资源。具体来说， 扩大现有研究的研究地点数量，并增加了几个新项目 大大增加了核心的责任，包括额外的监督、质量控制、分析和 Michael E.DeBakey VA医疗中心(MEDVAMC)核心调查员和 工作人员。 项目目标：神经成像核心的目标是：1)协助获取脑成像 数据，包括常规磁共振成像(MRI)、详细体积测量和皮质厚度， 弥散张量成像(DTI)、动脉自旋标记(ASL)和静息状态功能连接性MRI (FcMRI)；2)传输、转换、分析和存储脑成像数据；3)指导和协助执行质量 确保参与成像数据收集的所有地点的扫描仪；以及4)与 涉及成像的项目的调查人员，以促进将成像数据整合到项目中以解决 他们的目标。 项目方法：核心调查人员的集体专门知识有助于利用和分析 几种常规和先进的成像技术。基于MEDVAMC的核心人员，包括MR 物理学家，监督每个磁铁的质量保证测试，定期执行，以确保 扫描仪的准确性、稳定性和可比性。核心人员协助脉冲编程和排序 用于特定项目的高级磁共振序列的开发。核心调查人员提供了额外的 对磁共振技术人员和项目协调员进行培训，使参与者做好接受成像的准备。 核心人员还提供计算机编程方面的协助，以促进数据分类和 分析。由于传输和存储大量数据的复杂性以及频繁 一些图像分析程序所需的软件更新，具有IT专业知识的个人也参与其中。 核心人员还培训和监督所有图像分析员，协助解释图像数据，以及 协助稿件准备工作。