Direct determination of the role of aponeurosis in modulating muscle mechanics

直接测定腱膜在调节肌肉力学中的作用

• 批准号: 9319209
• 负责人: Carolyn Margaret Eng
• 金额: $ 5.92万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9319209
• 关键词: Address; Adrenal Cortex Hormones; Age; Architecture; Connective Tissue; Contracts; Disease; Elastic Tissue; Elements; Fascia; Fiber; Gastrocnemius Muscle; Goals; Human; Imaging Techniques; In Situ; Injection of therapeutic agent; Injury; Interruption; Intramuscular; Lateral; Lead; Length; Limb structure; Link; Measures; Mechanics; Meleagris gallopavo; Modeling; Modification; Movement; Muscle; Muscle Contraction; Muscle Fibers; Muscle function; Musculoskeletal; Operative Surgical Procedures; Outcome; Output; Predisposition; Preparation; Property; Radial; Rehabilitation therapy; Research; Role; Series; Shapes; Speed; Stretching; Structure; Surgical incisions; Tendon structure; Testing; Three-Dimensional Imaging; Work; aponeurosis; experimental study; improved; muscle strength; novel; older patient; pressure; prevent; public health relevance

 DESCRIPTION (provided by applicant): Elastic tissues in series and in parallel with muscle have a profound influence on muscle mechanics and energetics. Planar elastic tissues including aponeurosis and fascia are intimately connected with muscles and only recently have we begun to understand the extent of their influence on muscle force, speed, and power. By forming a sheath around a large portion of the muscle belly, aponeurosis is hypothesized to govern the shape changes that muscle undergoes during contractions but this has never been directly tested. Through this influence on muscle shape, the aponeurosis may modulate the speed and force of contraction. Changes in connective tissue stiffness occur with age and disease and may interfere with the aponeurosis' ability to match muscle shape changes to muscle demand, which could have detrimental effects during damaging lengthening contractions. By modifying the structure and stiffness of the aponeurosis, this project will directly examine the role of aponeurosis in modulating muscle shape changes and test how similar alterations occurring after surgical intervention or with injury, age, or disease influence the mechanics of muscle contraction. This study will also explore the link between altered aponeurosis stiffness and muscle damage to address whether changes in aponeurosis properties related to age or disease increase the muscle's susceptibility to injury. The proposed experiment will use a novel 3D imaging technique to visualize the dynamic changes in muscle shape, muscle length, and fiber length in an in situ muscle preparation in a turkey. The specific aims of this project are: 1 to determine the role of the planar structure of aponeurosis in maintaining intramuscular pressure and modulating muscle force and speed during contractions; 2) to determine the role of aponeurosis stiffness in modulating muscle force and speed and preventing muscle damage. The results of the proposed experiments have the potential to improve surgical outcomes and inform rehabilitative strategies targeting connective tissue properties after injury or disease. Th proposed work will form the basis for future research investigating how planar connective tissues integrate function within and among muscles and between limb segments and incorporating planar connective tissues into musculoskeletal models of human movement to further explore how modifications of connective tissue properties related to injury, age, disease, or surgical intervention alter muscle and locomotor function.

 描述（由申请人提供）：与肌肉串联和并联的弹性组织对肌肉力学和能量学具有深远的影响。平面弹性组织包括腱膜和筋膜与肌肉密切相关，直到最近我们才开始了解它们对肌肉力量，速度和力量的影响程度。通过在大部分肌腹周围形成鞘，假设腱膜控制肌肉在收缩期间经历的形状变化，但这从未被直接测试过。通过这种对肌肉形状的影响，腱膜可以调节收缩的速度和力量。结缔组织硬度的变化随着年龄和疾病而发生，并且可能干扰腱膜将肌肉形状变化与肌肉需求相匹配的能力，这可能在破坏性延长收缩期间产生有害影响。通过修改腱膜的结构和刚度，该项目将直接检查腱膜在调节肌肉形状变化中的作用，并测试手术干预后或受伤，年龄或疾病后发生的类似变化如何影响肌肉收缩的力学。本研究还将探讨腱膜硬度改变与肌肉损伤之间的联系，以解决与年龄或疾病相关的腱膜特性变化是否会增加肌肉对损伤的敏感性。拟议的实验将使用一种新的3D成像技术来可视化肌肉形状，肌肉长度和纤维长度在火鸡原位肌肉制备中的动态变化。本课题的具体目的是：1）确定腱膜平面结构在维持肌内压力和调节收缩过程中肌肉力量和速度中的作用; 2）确定腱膜刚度在调节肌肉力量和速度以及防止肌肉损伤中的作用。拟议实验的结果有可能改善手术结果，并为损伤或疾病后针对结缔组织特性的康复策略提供信息。这项工作将成为未来研究的基础，研究平面结缔组织如何整合肌肉内和肌肉之间以及肢体节段之间的功能，并将平面结缔组织纳入人体运动的肌肉骨骼模型，以进一步探索与损伤，年龄，疾病或手术干预相关的结缔组织特性的修改如何改变肌肉和运动功能。