FASEB SRC on Lipid Droplets on the Move from Health to Disease

FASEB SRC 关于脂滴从健康到疾病的转变

• 批准号: 9543174
• 负责人: PERRY E BICKEL
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9543174
• 关键词: Address; Atherosclerosis; Biochemical; Biochemistry; Biogenesis; Biological Models; Biology; Biophysics; Cardiovascular Diseases; Cells; Cellular biology; Characteristics; Clinical Research; Collaborations; Colorado; Cultured Cells; Development; Diabetes Mellitus; Disabled Persons; Disease; Drosophila genus; Educational workshop; Endocrinology; Energy Metabolism; Epidemic; Equilibrium; Feedback; Fostering; Functional disorder; Funding; Genetic; Genetic Determinism; Grant; Health; Human; Imaging technology; Immunity; Insulin Resistance; International; Lipid Inclusion; Lipids; Lipodystrophy; Lipolysis; Malignant Neoplasms; Medicine; Metabolic Diseases; Metabolic syndrome; Metabolism; Minority; Modeling; Movement; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Nerve Degeneration; Neurodegenerative Disorders; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oral; Organ; Organelles; Participant; Pathology; Physiology; Play; Postdoctoral Fellow; Prevalence; Prevention strategy; Process; Request for Applications; Research; Research Personnel; Resort; Scientist; Site; Students; Time; Tissues; Training; Underrepresented Minority; United States National Institutes of Health; Woman; Work; Writing; Yeasts; biophysical properties; career; collaborative environment; design; experience; fly; graduate student; innovation; insight; meetings; microscopic imaging; next generation; non-alcoholic fatty liver disease; novel; novel therapeutic intervention; oxidation; posters; programs; student training; summer research; symposium; trafficking; tumor metabolism

Project Summary The 6th FASEB Summer Research Conference on Lipid Droplets, entitled “Lipid Droplets on the Move from Health to Disease,” will focus on the rapidly developing field of lipid droplet biology. Lipid droplets are dynamic cellular organelles that play key roles in energy metabolism. Lipid droplet accumulation and dysfunction are hallmarks of metabolic diseases, including obesity, lipodystrophy, insulin resistance, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. Lipid droplets are increasingly being studied in the contexts of cancer metabolism, neurodegeneration and immunity as well. The increasing prevalence of metabolic disorders throughout the world lends increased urgency to encouraging research into fundamental aspects of how lipid droplets form, grow, move, mature, and degrade and how lipid droplets influence cell, tissue and organismal physiology and contribute to disease. Understanding of these concepts is necessary for the rationale design appropriate new therapeutic strategies. The conference will be held from June 24-29, 2018 at the Steamboat Grand Resort in Steamboat Springs, CO. The format includes an opening night keynote address by Lewis Cantley, eight sessions of talks by invited speakers, as well as short talks by trainees and early career investigators selected from submitted abstracts, four poster sessions, a Career Workshop on career design and balance, and a Meet the Experts session on advanced imaging microscopy. The meeting format will encourage and facilitate interactions between trainees, early career investigators and established investigators. The scientific sessions cover the full breadth of lipid-droplet biology, from biophysical, biochemical, and cellular topics to physiology and disease. Talks from internationally renowned researchers will span basic to clinical research and describe diverse approaches (biophysics, genetics, biochemistry, cell biology, physiology) and models (mice, humans, cultured cells, flies, yeast). This meeting continues to represent THE major international meeting dedicated exclusively to lipid droplets and remains a unique forum for researchers to exchange ideas and share breaking results in this dynamic and timely field. A central aim of this conference is training and encouraging the next generation of scientists. This application requests funding to support the participation of 14 graduate students, postdoctoral fellows and early career investigators, including women, underrepresented minorities, and persons with disabilities, who will be chosen from submitted abstracts judged as superior. The intimate conference format, the secluded conference site, and the many opportunities for informal interactions between participants, planned and unplanned, will provide young investigators opportunities to present their work, to obtain feedback from leaders in the field, and to get career advice.

项目摘要 第六届FASEB夏季脂质滴研究会议，题为“脂质滴从 健康与疾病”将集中在迅速发展的脂滴生物学领域。脂滴是动态的 在能量代谢中起关键作用的细胞器。脂滴积聚和功能障碍是 代谢疾病的标志，包括肥胖、脂肪代谢障碍、胰岛素抵抗、糖尿病、非酒精性 脂肪肝和心血管疾病。脂滴越来越多地被研究的背景下， 癌症代谢、神经变性和免疫力。代谢性疾病的日益普遍 世界各地的疾病增加了鼓励研究的紧迫性， 脂滴如何形成、生长、移动、成熟和降解，以及脂滴如何影响细胞、组织和 生物生理学，并有助于疾病。理解这些概念对于 合理设计新的治疗策略。会议将于2018年6月24日至29日在 汽船大度假村在汽船泉，有限公司的格式包括开幕之夜的主题演讲 刘易斯·坎特利的演讲，八场特邀演讲者的演讲，以及受训人员的简短演讲， 从提交的摘要中选出的早期职业研究者，四个海报会议，一个关于 职业生涯设计和平衡，并会见了先进的成像显微镜专家会议。会议 这种形式将鼓励和促进受训人员、早期职业调查人员和已建立的 investigators.科学会议涵盖了脂滴生物学的全部内容，从生物物理学， 生物化学和细胞的主题，生理学和疾病。国际知名研究人员的演讲 将涵盖基础到临床研究，并描述不同的方法（生物物理学，遗传学，生物化学，细胞 生物学、生理学）和模型（小鼠、人类、培养细胞、苍蝇、酵母）。本次会议继续 代表主要的国际会议专门致力于脂滴，仍然是一个独特的论坛 让研究人员交流思想，分享这一动态和及时领域的突破性成果。一个中心目标， 这次会议是在培养和鼓励下一代科学家。该申请要求提供资金 支持14名研究生、博士后研究员和早期职业调查人员的参与， 包括妇女、代表性不足的少数民族和残疾人，他们将从 提交的摘要被评为上级。私密的会议形式，僻静的会议场地， 参与者之间有计划和无计划的非正式互动的许多机会，将为年轻人提供 调查人员有机会展示他们的工作，从该领域的领导者那里获得反馈，并获得职业发展。 建议.