FASEB SRC on Lipid Droplets on the Move from Health to Disease

项目摘要 第六届FASE B关于脂滴的夏季研究会议，题为《脂滴从 健康与疾病“将侧重于快速发展的脂滴生物学领域。脂滴是动态的 在能量代谢中起关键作用的细胞器。脂滴堆积和功能障碍 代谢性疾病的特征，包括肥胖、脂肪营养不良、胰岛素抵抗、糖尿病、非酒精性 脂肪肝和心血管疾病。越来越多的人在以下背景下研究脂滴 癌症代谢、神经退化和免疫也是如此。代谢性疾病日益盛行 世界各地的疾病使鼓励对疾病基本方面的研究变得更加紧迫 脂滴如何形成、生长、移动、成熟和降解，以及脂滴如何影响细胞、组织和 生物体生理学和致病因素。理解这些概念对于 合理设计合适的新治疗策略。大会将于2018年6月24日至29日在 科罗拉多州斯普林斯的汽船大度假村。格式包括开幕之夜的主旨演讲 刘易斯·坎特利的演讲，特邀演讲者的八次演讲，以及受训人员和 早期职业调查人员从提交的摘要中挑选出来，四次海报会议，关于 职业生涯设计和平衡，以及高级成像显微镜专家会议。这次会议 形式将鼓励和促进实习生、早期职业调查人员和现有人员之间的互动 调查人员。科学会议涵盖了脂滴生物学的全部内容，从生物物理学， 生物化学、细胞学、生理学和疾病。来自国际知名研究人员的演讲 将跨越基础研究到临床研究，并描述不同的方法(生物物理、遗传学、生物化学、细胞 生物学、生理学)和模型(小鼠、人类、培养细胞、苍蝇、酵母)。本次会议将继续 代表专门讨论脂滴问题的主要国际会议，并仍然是一个独特的论坛 供研究人员在这一动态和及时的领域交流思想和分享突破性成果。的核心目标是 这次会议是在培养和鼓励下一代科学家。此应用程序请求提供资金 为支持14名研究生、博士后研究员和早期职业调查人员的参与， 包括妇女、任职人数不足的少数群体和残疾人，他们将从 提交的被评为优秀的摘要。私密的会议形式、隐蔽的会议地点和 许多参与者之间非正式互动的机会，无论是计划内的还是计划外的，都将为年轻人提供 调查人员有机会展示他们的工作，从该领域的领导者那里获得反馈，并获得职业生涯 建议。

Project Summary The 6th FASEB Summer Research Conference on Lipid Droplets, entitled “Lipid Droplets on the Move from Health to Disease,” will focus on the rapidly developing field of lipid droplet biology. Lipid droplets are dynamic cellular organelles that play key roles in energy metabolism. Lipid droplet accumulation and dysfunction are hallmarks of metabolic diseases, including obesity, lipodystrophy, insulin resistance, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. Lipid droplets are increasingly being studied in the contexts of cancer metabolism, neurodegeneration and immunity as well. The increasing prevalence of metabolic disorders throughout the world lends increased urgency to encouraging research into fundamental aspects of how lipid droplets form, grow, move, mature, and degrade and how lipid droplets influence cell, tissue and organismal physiology and contribute to disease. Understanding of these concepts is necessary for the rationale design appropriate new therapeutic strategies. The conference will be held from June 24-29, 2018 at the Steamboat Grand Resort in Steamboat Springs, CO. The format includes an opening night keynote address by Lewis Cantley, eight sessions of talks by invited speakers, as well as short talks by trainees and early career investigators selected from submitted abstracts, four poster sessions, a Career Workshop on career design and balance, and a Meet the Experts session on advanced imaging microscopy. The meeting format will encourage and facilitate interactions between trainees, early career investigators and established investigators. The scientific sessions cover the full breadth of lipid-droplet biology, from biophysical, biochemical, and cellular topics to physiology and disease. Talks from internationally renowned researchers will span basic to clinical research and describe diverse approaches (biophysics, genetics, biochemistry, cell biology, physiology) and models (mice, humans, cultured cells, flies, yeast). This meeting continues to represent THE major international meeting dedicated exclusively to lipid droplets and remains a unique forum for researchers to exchange ideas and share breaking results in this dynamic and timely field. A central aim of this conference is training and encouraging the next generation of scientists. This application requests funding to support the participation of 14 graduate students, postdoctoral fellows and early career investigators, including women, underrepresented minorities, and persons with disabilities, who will be chosen from submitted abstracts judged as superior. The intimate conference format, the secluded conference site, and the many opportunities for informal interactions between participants, planned and unplanned, will provide young investigators opportunities to present their work, to obtain feedback from leaders in the field, and to get career advice.