Noguchi Institute Initiative for NTDs Elimination (NIINE)

野口研究所消除被忽视热带病倡议 (NIINE)

• 批准号: 9286399
• 负责人: Michael D Wilson
• 金额: $ 34.52万
• 依托单位: NOGUCHI MEMORIAL INSTITUTE / MEDICAL RES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-14 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9286399
• 关键词: Adult; Albendazole; Anemia; Animal Husbandry; Anthelmintics; Antibodies; Antibody Response; Antigen Presentation; Antigens; Area; Categories; Child; Communities; Community Practice; Community of Practice; Country; Detection; Dose; Drug resistance; Drug-sensitive; Effectiveness; Epidemiology; Evaluation; Feeds; Future; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic Variation; Ghana; Goals; Health Benefit; Helminthiasis; Helminths; Hookworm Infections; Hookworms; Human; IgE; IgG1; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunology; In Vitro; Individual; Infection; Institutes; Institution; Interdisciplinary Study; Intervention; Longitudinal Studies; MHC Class I Genes; Malaria; Malnutrition; Maps; Measures; Mediating; Microscopy; Molecular; Molecular Profiling; Monitor; Movement; Municipalities; Nature; Nutritional status; Parasite resistance; Parasites; Parasitic Diseases; Pathway interactions; Pattern; Pharmaceutical Preparations; Pharmacotherapy; Population; Population Genetics; Praziquantel; Predisposition; Preventive; Proteins; Public Health; Research; Research Infrastructure; Research Training; Resistance; Resistance development; Resources; Risk; Risk Factors; Role; Schistosoma hematobium infection; Schistosomiasis; School-Age Population; Scientist; Sentinel; Site; Soil; Structure; Testing; Training; Treatment Failure; Treatment outcome; Work; absorption; base; candidate marker; chemokine; chemotherapy; co-infection; cytokine; cytotoxicity; design; experimental study; falls; feeding; genome sequencing; global health; immunological status; immunoregulation; improved; in vivo; malaria infection; molecular marker; multidisciplinary; programs; resistance gene; response; social; study population; targeted sequencing; time interval; tool; transcriptome sequencing; transmission process; treatment response; whole genome

Overall summary Hookworms infect nearly one billion people worldwide, and are a leading cause of anemia and malnutrition in resource-limited countries. Current global strategies to control hookworm and other Soil Transmitted Helminths rely on repeated mass drug administration of albendazole. Recent evidence confirms that deworming drugs are losing effectiveness against hookworm in endemic areas, and the emergence of genetically mediated resistance would have potentially devastating public health implications. The studies in adults and school-age children conducted in the Kintampo North Municipality (KNM), Ghana confirm the overall poor efficacy of albendazole. We hypothesize that treatment responses and reinfections are associated with the nutritional and immune status of the individual, community practices, and parasites' genetics, implying that there is multifactorial mechanism of hookworm treatment failure. In order to test this hypothesis, we propose to conduct research in four specific domains; epidemiology, immunology, parasite population genetics and identification of molecular biomarkers of albendazole resistance for monitoring and surveillance. Over the course of the 5 year study period, this TMRC project will support collaborative research and training to build capacity in parasitic diseases research, building on the longstanding record of the Ghana-Yale Partnership for Global Health and recently, with UMASS.

总体汇总 钩虫感染全球近10亿人，是贫血的主要原因 和营养不良的问题。当前控制钩虫病的全球战略 和其他土壤传播的蠕虫依赖于重复的大规模药物管理， 阿苯达唑最近的证据证实，驱虫药正在失去效力 在流行地区防治钩虫，以及出现遗传介导的抗药性 会对公众健康造成潜在的破坏性影响在成人中的研究， 在加纳北金坦波市（KNM）进行的学龄儿童调查证实， 阿苯达唑总体疗效差。我们假设治疗反应和 再感染与个体的营养和免疫状态有关， 社区实践和寄生虫遗传学，暗示存在多因素机制 钩虫治疗失败为了验证这一假设，我们建议进行 四个特定领域的研究：流行病学、免疫学、寄生虫种群遗传学 和鉴定用于监测的阿苯达唑抗性的分子生物标志物， 监视在5年的研究期间，该TMRC项目将支持 合作研究和培训，以建立寄生虫病研究能力， 根据加纳-耶鲁全球健康伙伴关系的长期记录， 关于UMASS