三维转录调控的组学分析-猫眼课题宝

三维转录调控的组学分析

批准号：

9207004

负责人：

Victor Jin

金额：

$32.52万

依托单位：

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

依托单位国家：

美国

项目类别：

财政年份：

2015

资助国家：

美国

项目状态：

已结题

起止时间：

2015-04-13 至 2019-01-31

来源：

https://reporter.nih.gov/project-details/9207004

关键词：

Alpha Cell Apoptosis Architecture Bayesian Modeling Bioinformatics Biological Biological Assay Biological Models Breast Cancer Cell Breast Cancer cell line Cell Nucleus Cell Proliferation Chromatin Communities Complex Computing Methodologies Coupled DNA Methylation Data Dimensions EZH2 gene Endocrine Estrogen Receptor alpha Estrogens Euchromatin Frequencies Gene Expression Regulation Gene Targeting Genes Genetic Transcription Genomics Goals Heterochromatin High-Throughput Nucleotide Sequencing Histones Hormones Laboratories Laws Location MCF7 cell Maps Measures Mediating Modeling Molecular Conformation Names Nuclear Oncogenic Phenotype Recruitment Activity Resistance Resolution Role Statistical Models Stimulus Structure Tamoxifen Testing Three-dimensional analysis Time Transcriptional Regulation cell type chromosome conformation capture histone modification malignant breast neoplasm public health relevance small hairpin RNA three dimensional structure three-dimensional modeling tool transcription factor

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DESCRIPTION (provided by applicant): In this R01 proposal, we plan to use an integrative genomics (Omics) analysis to test two central hypotheses: 1) TF modules form different transcriptional chromatin hubs and co-regulate dynamical interactomes; and 2) an environmental or cellular stimulus such as hormones triggers different transcription modulators to facilitate dynamical chromatin conformation changes. The ultimate goal is to model and analyze TF modules from one- dimension (1D) to three-dimension (3D) scale and describe the relationship between chromatin organization and TF modules. Using a model system of ERa in breast cancer, our studies will examine 1) E2-mediated dynamic TF transcription modules and chromatin interactions; and 2) these hubs and interacting domains are altered in tamoxifen resistant breast cancer cells. The successful completion of our proposed studies will be of value to the genomics community and biologists in general, which may result in the better understanding of the principle of 3D transcriptional regulation and the regulatory role of E2/ERa in endocrine resistant breast cancer.

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