Mutational signatures of DDT: The role of a controversial persistent endocrine disrupting pollutant on prostate cancer aetiology

目前还没有发现前列腺癌的致癌物或预防方法。由于致癌物通常是诱变剂，我们将使用基因组询问来确定在40年代到80年代后期广泛使用激素干扰杀虫剂DDT是否会增加全球PCa。从经生化证实终身接触滴滴涕的男性身上获取前列腺肿瘤，将为评估滴滴涕在全球（包括澳大利亚）的影响提供可测量的基因组特征。

No carcinogen or prevention has been identified for prostate cancer (PCa). As carcinogens are commonly mutagens, we will use genomic interrogation to determine if extensive use of the hormone-disrupting pesticide DDT during the 40's to late 80's increased PCa globally. Having access to prostate tumours from men with biochemically confirmed lifelong DDT-exposure, will provide a measurable genomic signature to evaluate the impact of DDT globally, including Australia.