Translational regulation of the breast cancer stem cell by eIF4G1

eIF4G1 对乳腺癌干细胞的翻译调控

• 批准号: 9478131
• 负责人: Robert Schneider
• 金额: $ 40.56万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-05 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9478131
• 关键词: Animal Model; Biology; Breast cancer metastasis; Cell Line; Cell Survival; DNA Damage; DNA Repair; Development; Genetic Translation; Messenger RNA; Metastatic breast cancer; Molecular; Neoplasm Metastasis; Proteins; Proteome; Research; Resistance; Role; Specimen; Study models; Translational Regulation; Translations; angiogenesis; breast cancer progression; cancer seeding; cancer stem cell; malignant breast neoplasm; overexpression; public health relevance; response; tumor

 DESCRIPTION (provided by applicant): This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.

 描述（由申请人提供）：本研究旨在了解翻译调控在乳腺癌干细胞（CSC）生物学中的重要作用，包括其对DNA损伤的显著存活及其对转移的贡献。已经发现选择性mRNA翻译和帽依赖性翻译机制中的特异性改变在乳腺癌的发生、进展和转移中至关重要。