Translational regulation of the breast cancer stem cell by eIF4G1
Translational regulation of the breast cancer stem cell by eIF4G1
批准号:
9478131
负责人:
Robert Schneider
金额:
$40.56万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-05-05 至 2020-04-30
关键词:
Animal ModelBiologyBreast cancer metastasisCell LineCell SurvivalDNA DamageDNA RepairDevelopmentGenetic TranslationMessenger RNAMetastatic breast cancerMolecularNeoplasm MetastasisProteinsProteomeResearchResistanceRoleSpecimenStudy modelsTranslational RegulationTranslationsangiogenesisbreast cancer progressioncancer seedingcancer stem cellmalignant breast neoplasmoverexpressionpublic health relevanceresponsetumor
中文摘要
描述(申请人提供):这项研究旨在了解翻译调控在乳腺癌干细胞(CSCs)生物学中的重要作用,包括它们在抵抗DNA损伤时的显著存活以及它们对转移的贡献。选择性的信使核糖核酸翻译和依赖帽的翻译机制的特异性改变被发现在乳腺癌的发生、发展和转移中起着至关重要的作用。
英文摘要
DESCRIPTION (provided by applicant): This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DAP5-dependent translational control and breast cancer metastasis
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批准号:10349506
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项目类别:
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资助金额:$50.48万
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财政年份:2020
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负责人:Robert Schneider
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依托单位:
DAP5-dependent translational control and breast cancer metastasis
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批准号:10577813
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项目类别:
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资助金额:$50.48万
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财政年份:2020
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负责人:Robert Schneider
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依托单位:
DAP5-dependent translational control and breast cancer metastasis
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批准号:10117215
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项目类别:
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资助金额:$51.51万
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财政年份:2020
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负责人:Robert Schneider
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依托单位:
Accelerated and programmed mRNA decay by AU-rich binding protein AUF1 in the regulation of muscle regeneration
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批准号:10531231
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项目类别:
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资助金额:$46.54万
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财政年份:2018
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负责人:Robert Schneider
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依托单位:
Translational Regulation of T Regulatory Cells
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批准号:10356140
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项目类别:
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资助金额:$60.64万
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财政年份:2018
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负责人:Robert Schneider
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依托单位:
Accelerated and programmed mRNA decay by AU-rich binding protein AUF1 in the regulation of muscle regeneration
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批准号:10061554
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项目类别:
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资助金额:$45.14万
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财政年份:2018
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负责人:Robert Schneider
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依托单位:
Accelerated and programmed mRNA decay by AU-rich binding protein AUF1 in the regulation of muscle regeneration
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批准号:10311077
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项目类别:
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资助金额:$41.89万
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财政年份:2018
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负责人:Robert Schneider
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依托单位:
the mTOR translational control pathway in tamoxifen resistant ER+ breast cancer
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批准号:9311090
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项目类别:
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资助金额:$42.35万
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财政年份:2017
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负责人:Robert Schneider
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依托单位:
the mTOR translational control pathway in tamoxifen resistant ER+ breast cancer
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批准号:10166782
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项目类别:
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资助金额:$44.04万
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财政年份:2017
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负责人:Robert Schneider
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依托单位:
the mTOR translational control pathway in tamoxifen resistant ER+ breast cancer
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批准号:9889930
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项目类别:
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资助金额:$43.54万
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财政年份:2017
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负责人:Robert Schneider
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依托单位:
Ionizing radiation control of inflammatory cytokine mRNA stability and expression
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批准号:8670320
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项目类别:
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资助金额:$32.86万
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财政年份:2013
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负责人:Robert Schneider
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依托单位:
Ionizing Radiation Control of Inflammatory Cytokine mRNA Stability and Expression
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批准号:8068638
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项目类别:
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资助金额:$33.23万
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财政年份:2009
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负责人:Robert Schneider
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依托单位:
Ionizing Radiation Control of Inflammatory Cytokine mRNA Stability and Expression
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批准号:8258799
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项目类别:
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资助金额:$33.23万
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财政年份:2009
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负责人:Robert Schneider
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依托单位:
Ionizing Radiation Control of Inflammatory Cytokine mRNA Stability and Expression
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批准号:7790600
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项目类别:
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资助金额:$33.56万
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财政年份:2009
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负责人:Robert Schneider
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依托单位:
BIOCHEMICAL AND TRANSLATION CONTROL OF CYTOKINE MRNA DEC
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批准号:6351329
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项目类别:
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资助金额:$25.64万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
Control of Cytoxine mRNA Stability by AUF1
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批准号:7068388
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项目类别:
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资助金额:$4.15万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
BIOCHEMICAL AND TRANSLATION CONTROL OF CYTOKINE MRNA DEC
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批准号:6498716
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项目类别:
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资助金额:$25.82万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
Control of Cytokine mRNA Stability by AUF1
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批准号:6777423
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项目类别:
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资助金额:$32.11万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
Control of Cytokine mRNA Stability by AUF1
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批准号:7215177
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项目类别:
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资助金额:$32.47万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
Control of Cytoxine mRNA Stability by AUF1
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批准号:7028363
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项目类别:
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资助金额:$37.44万
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财政年份:2000
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负责人:Robert Schneider
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: