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Translational regulation of the breast cancer stem cell by eIF4G1

Translational regulation of the breast cancer stem cell by eIF4G1
eIF4G1 对乳腺癌干细胞的翻译调控
批准号:
9478131
负责人:
Robert Schneider
金额:
$40.56万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-05-05 至 2020-04-30

项目摘要

项目成果

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中文摘要
翻译
 描述(申请人提供):这项研究旨在了解翻译调控在乳腺癌干细胞(CSCs)生物学中的重要作用,包括它们在抵抗DNA损伤时的显著存活以及它们对转移的贡献。选择性的信使核糖核酸翻译和依赖帽的翻译机制的特异性改变被发现在乳腺癌的发生、发展和转移中起着至关重要的作用。
英文摘要
 DESCRIPTION (provided by applicant): This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.
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会议论文
DAP5-dependent translational control and breast cancer metastasis
DAP5-dependent translational control and breast cancer metastasis
DAP5-dependent translational control and breast cancer metastasis
Accelerated and programmed mRNA decay by AU-rich binding protein AUF1 in the regulation of muscle regeneration
国内基金
海外基金
Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 项目类别:
    专项基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2010
  • 负责人:
    贺萍
  • 依托单位: