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Translational regulation of the breast cancer stem cell by eIF4G1

Translational regulation of the breast cancer stem cell by eIF4G1
eIF4G1 对乳腺癌干细胞的翻译调控
批准号：
9478131
负责人：
Robert Schneider
金额：
$40.56万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-05-05 至 2020-04-30
来源：
https://reporter.nih.gov/project-details/9478131
关键词：
Animal ModelBiologyBreast cancer metastasisCell LineCell SurvivalDNA DamageDNA RepairDevelopmentGenetic TranslationMessenger RNAMetastatic breast cancerMolecularNeoplasm MetastasisProteinsProteomeResearchResistanceRoleSpecimenStudy modelsTranslational RegulationTranslationsangiogenesisbreast cancer progressioncancer seedingcancer stem cellmalignant breast neoplasmoverexpressionpublic health relevanceresponsetumor

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): This research is directed to understanding the essential role of translational regulation in the biology of breast cancer stem cells (CSCs), including their remarkable survival against DNA damage and their contribution to metastasis. Selective mRNA translation and specific alterations in the cap-dependent translation machinery have been found to be crucial in breast cancer development, progression and metastasis.
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海外基金
Journal of Integrative Plant Biology
  • 批准号：
    31024801
  • 项目类别：
    专项基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2010
  • 负责人：
    贺萍
  • 依托单位：
    中国科学院植物研究所