Research Methods Core

研究方法核心摘要 酒精研究和教育中心（NCARE）研究方法核心致力于 优化美国印第安人和阿拉斯加原住民人群的酒精使用障碍研究（AI/AN）。成功 酒精干预研究需要设计可衡量的，可实现的目标;充足的资金和 有效的资源分配;文化上适当的执行;以及定期评估。以本机 社区，这样的工作需要一个丰富的证据基础，由最先进的科学告知，并以 AI/AN人员的日常经验和文化。本核心的目标是最大限度地有效利用研究 通过对所有3个研究项目的测量和数据分析进行标准化， 和外部研究的有效性;并确保医疗保健提供者推理分析的相关性， 政策制定者、社区领袖和其他利益相关者，努力改善与审计相关的差异， 人工智能/人工神经网络。核心成员将与主要研究者和研究团队密切合作， 研究设计、样本选择、测量、数据收集、数据分析和结果传播。我们 跨学科方法整合了流行病学和因果推理理论的各种方法， 生物统计学、医学、临床试验、卫生服务、政策和卫生经济学。我们增强了这种专业知识 在定性方法方面有着非凡的经验。我们的具体目标是：1）应用最先进的研究 设计和抽样策略，以研究AI/AN中的AUD差异。这项工作包括确保 所有研究措施的可靠性和有效性，有效地利用NCARE资源手动操作， 设计有效的问卷和数据收集方法，管理数据，进行统计分析， 将定性和定量方法相结合，编制数据，向科学界和非科学界传播， 2）为试点项目资助的接受者提供研究方法方面的支持和指导， NCARE研究员，后者的研究在结构化的职业发展计划中进行; 3)对拟议的研究项目进行系统的卫生经济学评估，重点是短期的 与酒精使用障碍相关的健康干预措施的长期成本效益。这个核心将最大化 科学严谨性，同时适应现实世界中出现的后勤和方法学挑战 研究的努力。我们经验丰富的团队可以进行最简单的分析， 研究项目的科学问题，但它也可以适当地应用复杂的设计和分析工具， 并将结果传达给接受过不同程度定量培训的受众。我们的分析师补充 他们的方法学专业知识，深刻理解健康研究的独特需求和挑战 与土著社区。

RESEARCH METHODS CORE ABSTRACT The Native Center for Alcohol Research and Education (NCARE) Research Methods Core is devoted to optimizing alcohol use disorder research in American Indian and Alaska Native populations (AI/AN). Successful alcohol intervention studies require designs with measurable, achievable objectives; adequate funding and efficient resource allocation; culturally appropriate implementation; and regular evaluation. In Native communities, such work requires a rich evidence base informed by state-of-the-art science and grounded in the day-to-day experience and culture of AI/AN people. The goals of this Core are to maximize efficient use of study resources by standardizing measurement and data analysis across all 3 Research Projects; to optimize internal and external study validity; and to ensure the relevance of inferential analyses for healthcare providers, policymakers, community leaders, and other stakeholders working to ameliorate AUD-related disparities for AI/ANs. Core members will work closely with the Principal Investigator and research teams on all aspects of study design, sample selection, measurement, data collection, data analysis, and dissemination of findings. Our transdisciplinary approach integrates diverse methods from epidemiology and causal inference theory, biostatistics, medicine, clinical trials, health services, policy, and health economics. We augment this expertise with exceptional experience in qualitative methods. Our Specific Aims are to: 1) Apply state-of-the-art research designs and sampling strategies to the study of AUD disparities in AI/ANs. This work includes ensuring the reliability and validity of all study measures, efficiently using NCARE resources to manualize operations, designing effective questionnaires and data collection methods, managing data, conducting statistical analyses, integrating qualitative and quantitative methods, and preparing data for dissemination to scientific and lay audiences; 2) Provide support and mentoring in research methods to recipients of Pilot Project funding and to NCARE Fellows, with the latter group’s research occurring within a structured career development program; and 3) Perform systematic health economics evaluations of the proposed Research Projects, focusing on the short- and long-term cost-effectiveness of alcohol use disorder-related health interventions. This Core will maximize scientific rigor while accommodating the logistical and methodological challenges that arise in real-world research endeavors. Our experienced team can facilitate the simplest possible analysis to answer each Research Project’s scientific questions, but it can also apply complex designs and analytic tools as appropriate, and will communicate results to audiences with varying levels of quantitative training. Our analysts complement their methodological expertise with a deep understanding of the unique needs and challenges of health research with Native communities.