Mapping normal developmental coupling between structural and functional brain networks and abnormalities associated with psychosis

绘制大脑结构和功能网络与精神病相关异常之间的正常发育耦合

• 批准号: 9610925
• 负责人: Graham Baum
• 金额: $ 4.45万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9610925
• 关键词: Adolescence; Adolescent; Adult; Age; Architecture; Area; Axon; Behavior; Behavioral; Brain; Brain region; Cognitive; Communities; Complex; Coupling; Data; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early Diagnosis; Etiology; Exhibits; Goals; Human; Image; Individual; Lead; Link; Longitudinal Studies; Machine Learning; Magnetic Resonance Imaging; Measures; Mental disorders; Neurons; Pathway interactions; Pattern; Philadelphia; Population; Population Study; Process; Psychopathology; Psychotic Disorders; Public Health; Risk; Schizophrenia; Science; Severities; Structure; Symptoms; Techniques; Testing; Work; Youth; adolescent brain development; base; brain abnormalities; clinical phenotype; cognitive control; cognitive development; cognitive process; cohort; complex biological systems; cost; critical period; disability; early childhood; effective therapy; executive function; functional plasticity; information processing; insight; learning strategy; myelination; network architecture; neuroimaging; novel; phenotypic data; recruit; relating to nervous system; theories; tool; white matter; young adult

PROJECT SUMMARY During adolescence, the human brain undergoes marked structural and functional refinements to support rapid cognitive and behavioral development. However, the relationship between developing white matter architecture and emergent functional connectivity remains poorly understood. It is imperative to elucidate developmental mechanisms underlying structure-function coupling in youth, as devastating mental disorders such as psychosis have been linked to the disruption of evolving brain connectivity during this epoch. Specifically, psychosis has been characterized by the anomalous functional integration of brain processes. This could result from the aberrant wiring of white matter connections during brain development, from aberrant processes of functional plasticity (activity-dependent myelination of axons linking neurons within functionally-relevant circuits), or both. This proposal will apply cutting-edge network science and machine learning tools to longitudinal neuroimaging and rich clinical phenotyping data acquired as a part of the Philadelphia Neurodevelopmental Cohort (n=503, ages 9-25 years old), a large community-based study of brain development. Moreover, the goal of this proposal is to (1) systematically characterize whether structural connectivity drives developmental changes in functional connectivity within brain modules, or vice versa, and (2) identify abnormalities of structure-function coupling associated with the longitudinal burden of psychosis spectrum symptoms. This work will test the overarching hypothesis that structural connectivity precedes and drives developmental changes in functional connectivity within distinct brain modules, and further, that the aberrant development of structure-function coupling will be associated with increased burden of psychosis spectrum symptoms. Successful completion of the proposed aims will provide critical new insights regarding both typical brain maturation and the neurodevelopmental etiology of psychosis. Notably, as diverse types of psychopathology are increasingly linked to atypical brain maturation, findings generated by this study could lead to earlier diagnosis and enhanced treatment for individuals at risk for developing mental disorders.

项目总结