Population-level assessment of early childhood vaccination timeliness, parental vaccine hesitancy, and immunization schedule adherence in the United States, including rural-urban disparities

对美国幼儿疫苗接种及时性、父母疫苗犹豫和免疫计划遵守情况的人群评估，包括城乡差异

• 批准号: 10344976
• 负责人: Sophia Raff Newcomer
• 金额: $ 42.93万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10344976
• 关键词: Achievement; Address; Adherence; Advisory Committees; Affect; Age; Algorithms; Area; Binomial Model; Birth; COVID-19 pandemic; Cessation of life; Child; Childhood; Communicable Diseases; Complex; Data; Data Sources; Disease; Disease Outbreaks; Dose; Goals; Immunization; Immunization Schedule; Intervention; Link; Measles; Measures; Methods; Modeling; Modification; Parents; Pattern; Pertussis; Population; Prevalence; Public Health; Records; Risk Factors; Rural; Schedule; Series; Services; Surveillance Methods; Surveys; Testing; Time; United States; Vaccinated; Vaccination; Vaccines; Vulnerable Populations; Work; contextual factors; disorder control; disorder risk; early childhood; experience; health care availability; health equity; health goals; improved; novel; population based; prevent; public health intervention; rural area; rurality; socioeconomics; standard measure; suburb; trend; urban disparity; vaccination schedule; vaccine acceptance; vaccine hesitancy

Project Summary/Abstract Delivery of early childhood vaccines using an established schedule is a key strategy for infectious disease control in the United States. However, between 50% and 75% of U.S. children experience undervaccination, defined as either getting some or all recommended vaccines late or not getting them at all, before their 2nd birthday. Outbreaks of measles, pertussis, and other vaccine-preventable diseases have been linked to children who were behind on or missing vaccines, either due to parental vaccine hesitancy or other barriers to accessing immunization services. There are currently no systematic, population-based approaches for tracking adherence to the U.S. recommended immunization schedule, or the prevalence of parents who choose to deviate from the recommended schedule. Furthermore, standard measures are inadequate for identifying the reasons why we fail to achieve vaccine coverage goals, which is a particular problem in populations that experience immunization disparities, including children living in the rural U.S. For this project, we will analyze 11 years of public use data collected in the National Immunization Survey-Child (NIS-Child) to quantify four novel measures of early childhood immunization services quality: (1) vaccine timeliness, (2) immunization schedule adherence, (3) undervaccination due to parental vaccine hesitancy, and (4) undervaccination due to other access barriers. In our analyses of this nationally representative data source, we will identify trends in and factors associated with these measures in the U.S. overall in 2011-2019 (Specific Aim 1a), for each U.S. state in 2011-2019 (Specific Aim 1b), and assess how the COVID-19 pandemic affected these trends in 2020-2021 (Specific Aim 1c). We will use mixed effects log-binomial models and zero-inflated Poisson models, as well as piecewise regression methods, to determine how time, socioeconomic, demographic, and other factors have affected these immunization quality measures in and across the U.S. Then, we will access restricted use NIS-Child data to determine how trends in and factors associated with immunization schedule adherence and specific undervaccination patterns are modified by rurality (Specific Aim 2). Our proposed analyses, along with our dissemination efforts, will contribute to the long-term goal of establishing methods for routine surveillance of these early childhood immunization services quality measures at national, state, and some local levels. Furthermore, this study will establish new data-driven methods for distinguishing between undervaccination due to parental vaccine hesitancy versus other healthcare access barriers; an important distinction, since interventions to address these two types of barriers fundamentally differ. The results from this project, and particularly the examinations of effect modification by rurality, will inform targeted interventions for increasing on-time vaccination and immunization schedule adherence, decreasing vaccine-preventable disease risk, and achieving immunization coverage equity in early childhood.

项目总结/文摘