针对同时发生慢性疼痛和阿片类药物使用障碍的退伍军人的综合治疗-猫眼课题宝

针对同时发生慢性疼痛和阿片类药物使用障碍的退伍军人的综合治疗

批准号：

10351460

负责人：

KEVIN E VOWLES

金额：

$10.57万

依托单位：

UNIVERSITY OF NEW MEXICO

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-09-30 至 2024-08-31

来源：

https://reporter.nih.gov/project-details/10351460

关键词：

Address Adherence Affect Aftercare Applications Grants Behavior Therapy Buprenorphine Clinic Clinical Practice Guideline Control Groups Data Analyses Development Education Educational workshop Faculty Workshop Fright Goals Individual Intervention Learning Love Manuscripts Measures Mental Depression Mental Health Mentors Methodology Mindfulness Training Modeling National Institute of Drug Abuse Opioid Outcome Outcome Measure Pain Pain intensity Pain interference Pain management Paper Patient Self-Report Patients Peer Review Phase Physicians Production Psychosocial Assessment and Care Public Health Randomized Randomized Clinical Trials Research Research Personnel Risk Risk Factors Statistical Methods Statistical Models Strategic Planning Substance abuse problem Techniques Time Training Training Activity United States Department of Veterans Affairs United States National Institutes of Health Urine Veterans Writing active method base biopsychosocial career chronic pain chronic pain patient clinical care craving disorder later incidence prevention dual diagnosis experience follow-up improved innovation mindfulness opioid misuse opioid use opioid use disorder pain reduction parent grant parent project prescription opioid primary outcome psychosocial recruit responsible research conduct secondary outcome social stigma substance misuse substance use symposium treatment adherence treatment effect treatment group

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中文摘要

翻译

项目描述：父母奖助金（4UH3DA051241; PI Witkiewitz）的目的是进行一项研究

英文摘要

Project Description: The aims of the Parent Grant (4UH3DA051241; PI Witkiewitz) are to conduct a randomized clinical trial to assess the efficacy of two empirically supported interventions: Acceptance and Commitment Therapy for chronic pain and Mindfulness Based Relapse Prevention for opioid use disorder (OUD). Efficacy will be assessed by examining pain interference and opioid use outcomes after three months of active treatment, as well as at 6 and 12 month follow-ups. Secondary outcomes, including depression, pain- related fears, and opioid misuse risk, will also be assessed at these same follow-ups. The study will also examine the relation between within-treatment changes in treatment mechanisms, including pain acceptance, engagement in values-based action, and opioid craving, and changes at post- treatment and follow-up. Data analysis will implement innovative statistical techniques to examine differences between treatment groups on outcome measures using a mixed-effects model with fixed effects of treatment and random effects of time. The results will potential enhance current clinical practice guidelines by developing unique psychosocial treatment that simultaneously addresses pain interference and opioid-related problems in an integrated format. The specific aims of the supplement are to (1) Identify psychosocial correlates of internalized stigma among patients with chronic pain and OUD (n = 160) who are receiving buprenorphine through a VA-based co- occurring disorders clinic; (2) Assess the impact of internalized stigma on treatment adherence among patients with co-occurring chronic pain and OUD; (3) Assess the impact of ACT+MBRP on reducing internalized stigma among patients with co-occurring chronic pain and OUD. These specific aims will identify psychosocial correlates of internalized stigma, evaluate the effects of internalized stigma on treatment adherence, and examine the effects of integrated treatment on reducing internalized stigma.

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