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Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics

次要大麻素和萜烯：作为镇痛药的临床前评估

基本信息

批准号：
10470160
负责人：
Thomas F Gamage
金额：
$ 8.8万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470160
关键词：
Absence of pain sensation Acetic Acids Acids Acute Pain Adverse effects Analgesics Animal Model Aspirin Behavior Biological Assay Breeding CNR1 gene CNR2 gene Calcium Channel Cannabidiol Cannabinoids Cannabis Cannabis sativa plant Capsaicin Catalepsy Characteristics Chemicals Chili Pepper Dependence Development Dose Enzyme-Linked Immunosorbent Assay Evaluation Flavoring GTP-Binding Proteins Goals Human Individual Inflammation Injections Investigation Legal patent Ligation Mediating Mediation Medicine Metabolic Pathway Metabolism Methods Minor Modeling Modernization Morbidity - disease rate Motor Activity Mus Natural Products Natural Remedy Opioid Opium Orphan Pain Pain Measurement Papaver Peripheral Pharmaceutical Preparations Pharmacologic Substance Plants Procedures Process Property Receptor Activation Recording of previous events Recreation Rodent Secure Signal Transduction Stretching TRP channel Tail Terpenes Testing Tetrahydrocannabinol Therapeutic Effect Therapeutic Uses Treatment Efficacy Trees Urine Visceral pain Willow abuse liability antinociception cannabimimetics combat cytokine drug development drug discrimination efficacy evaluation experimental study in vivo evaluation inflammatory pain mortality mouse model mu opioid receptors natural hypothermia non-opioid analgesic novel pain behavior pain patient pain perception pain relief pain sensation painful neuropathy phytocannabinoid pre-clinical preclinical evaluation receptor receptor binding sciatic nerve screening urinary

项目摘要

PROJECT SUMMARY Throughout recorded history, humans have used natural products for medicinal purposes. With the onset of modern analytical and pharmaceutical methods, the active ingredients in some of these “natural remedies” were identified and became foundational chemicals in drug development efforts. Among the numerous examples, aspirin (bark of the willow tree), capsaicin (chili peppers), and opioids (opium poppy plant) are notable for their analgesic properties. Similar to these other natural products, Cannabis sativa has long been used for medicinal purposes, including pain relief. The cannabis plant (Cannabis sativa/indica) contains over 100 phytocannabinoids as well as over 500 other identified chemicals, including the terpenoids that give cannabis its distinctive flavoring and aroma. Beyond 9-THC and CBD, however, difficulties in identifying, isolating and purifying minor phytocannabinoids in quantities sufficient for in vivo evaluation have hampered adequate investigation of potential therapeutic uses of individual phytocannabinoids. Recently, we have secured access to purified minor cannabinoids synthesized via a patented biosynthetic process in quantities that allow for preclinical in vivo testing. The goal of the proposed project is to provide a comprehensive evaluation of these compounds alone, and in planned combinations, to determine their potential efficacy as analgesics. In addition, we will conduct a parallel investigation of selected terpenes that have been identified in the cannabis plant. Novel analgesic strategies are needed to combat over-reliance on opioids and the resulting secondary consequences of dependence and morbidity/mortality.

项目总结