Cancer Epidemiology & Prevention (CEP) Program

项目总结/摘要（癌症流行病学和预防） 癌症流行病学和预防（CEP）计划是一组跨学科的人口健康和 进行研究以阐明癌症的环境、生活方式和遗传原因的医学科学家，以及 制定和测试预防和降低癌症风险的策略和干预措施。CEP计划成员 还专注于发展统计和数学方法，以推进癌症研究。该计划是 由来自17个不同部门和三所学校的29名成员组成， 580万美元的支持-其中470万美元（81%）来自NCI。成员生产力很高，有533个 项目期间的出版物，其中17.4%为计划内出版物，35.3%为计划间出版物， 纲领性的。调查人员参与方案内和方案间的互动，并积极合作 与密歇根大学综合癌症中心其他项目的研究人员合作。的CEP 该计划有三个主要的具体目标：1）阐明常见和高死亡率的风险和保护因素 癌症，重点是生活方式，环境和分子暴露; 2）发现和实施主要， 二级和三级预防战略，包括环境和个人暴露以及 最先进的基因组学、蛋白质组学、代谢组学和成像生物技术; 3）开发和实施 用于大数据和个性化预防和筛查的新型生物统计和分析方法。

PROJECT SUMMARY/ABSTRACT (CANCER EPIDEMIOLOGY AND PREVENTION) The Cancer Epidemiology and Prevention (CEP) Program is a group of interdisciplinary population health and medical scientists that conduct research to elucidate environmental, lifestyle and genetic causes of cancer, and develop and test strategies and interventions to prevent and reduce the risk of cancer. CEP program members also focus on developing statistical and mathematical approaches to advance cancer research. The program is comprised of 29 members from 17 different departments and three schools with total annual direct research support of $5.8 million - of which $4.7 million (81%) is from the NCI. Members are highly productive, with 533 publications during the project period, of which 17.4% are intra-programmatic and 35.3% are inter- programmatic. Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other University of Michigan Comprehensive Cancer Center programs. The CEP program has three main specific aims: 1) Elucidate risk and protective factors for common and high-mortality cancers, with a focus on lifestyle, environmental and molecular exposures; 2) Discover and implement primary, secondary and tertiary prevention strategies incorporating environmental and personal exposures and state-of- the-art genomic, proteomic, metabolomic, and imaging biotechnologies; and 3) Develop and operationalize novel biostatistical and analytic methods for big data and personalized prevention and screening.