Rab27 in tick extracellular vesicle biogenesis

Rab27 在蜱细胞外囊泡生物发生中的作用

• 批准号: 10381968
• 负责人: Lillian Rainer Butler
• 金额: $ 4.04万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381968
• 关键词: Affect; Anaplasma phagocytophilum; Anaplasmosis; Anesthetics; Anti-Inflammatory Agents; Anticoagulants; Arboviruses; Arthropod Vectors; Arthropods; Bacteria; Bacterial Infections; Biogenesis; Biology; Bite; Black-legged Tick; Blood; Cell Fractionation; Cell Line; Cell membrane; Cells; Cellular biology; Cessation of life; Classification; Clustered Regularly Interspaced Short Palindromic Repeats; Communicable Diseases; Communication; Complement; Culicidae; Disease Vectors; Early Endosome; Ectopic Expression; Endosomes; Environment; Genome; Goals; Human; Immune; Infection; Knock-out; Knowledge; Lead; Literature; Location; Mammals; Medical; Methods; Microbe; Modeling; Nucleic Acids; Organoids; Pathogenesis; Pathway interactions; Protein Family; Proteins; Reporting; Research; Resources; Rickettsia Infections; Role; Saliva; Salivary Glands; Site; Skin; System; Ticks; United States; Vector-transmitted infectious disease; arthropod-borne; disease transmission; emerging pathogen; exosome; expectation; extracellular; extracellular vesicles; feeding; granulocyte; in vivo; innovative technologies; insight; interest; late endosome; microbial; novel; pathogen; public health relevance; rab GTP-Binding Proteins; tick bite; tick saliva; transmission process; vector; vesicular release; wound

PROJECT SUMMARY/ABSTRACT The blacklegged tick, Ixodes scapularis, is the most medically relevant arthropod vector of infectious disease in the United States. It transmits over six pathogens of

项目摘要/摘要 黑腿tick t，ixodes capularis是传染性的最相关的节肢动物矢量 美国疾病。它传输了六个病原体