Bioassay Facility Core

生物测定设施核心

• 批准号: 10382451
• 负责人: JENNIFER C FUNG
• 金额: $ 46.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-22 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382451
• 关键词: Air; Animal Model; Area; Biological; Biological Assay; Biological Models; Biological Monitoring; Biological Process; California; Cells; Chemical Exposure; Chemical Models; Chemicals; Communities; Core Facility; Data Analyses; Defect; Detection; Development; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Epidemiology; Equipment; Evaluation; Evolution; Fostering; Funding; Goals; Growth; Hazardous Waste; Health; Health Professional; Human; Individual; Investments; Ions; Laboratories; Link; Mass Spectrum Analysis; Measurement; Measures; Monitor; Morphology; Mus; Organism; Pathway interactions; Peptides; Planet Earth; Poison; Procedures; Proteomics; Reaction; Reproducibility; Research; Research Design; Research Personnel; Resources; Sampling; Scientist; Services; Shotguns; Soil; Specialist; Specimen; Standardization; Stream; Technical Expertise; Technology; Tissue Sample; Tissues; Translations; Water; Xenograft procedure; base; community engagement; consumer product; cost; cost effective; data integration; experimental study; high throughput screening; human tissue; in vivo; innovation; member; new technology; novel; physiologic model; programs; reproductive; screening; small molecule libraries; tissue culture; tissue/cell culture; tool; toxicant

ABSTRACT - BIOASSAY FACILITY CORE The EaRTH Center Bioassay Facility Core will provide the enabling technology and expertise needed to advance cross-disciplinary environmental studies across the UCSF EaRTH Center research community. The EaRTH Center Bioassay Facility Core will offer several facilities to cover the majority of the EaRTH Center researchers needs: 1) an extensive biomonitoring facility providing chemical detection and measurement in many different media including air, water, soil, hazardous waste streams, consumer products and biological or human tissues; 2) state of the art SWATH mass spectrometry as well as traditional proteomics for assessing a chemical's effect on biological processes; 3) access to an extensive chemical library combined with ability to perform high- throughput in vivo chemical screening in a model organism and tissue culture; 4) novel xenografting of human tissue into mice to more realistically model chemical exposures. The Core therefore will enable EaRTH Center researchers to push the boundaries of environmental research by providing high-throughput, efficient and cost- effective chemical evaluation technologies.

摘要-生物测定设备核心