Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

项目摘要/摘要 治疗的进步大大延长了艾滋病毒携带者和许多人的预期寿命 每个人都活得很好，直到成年。艾滋病毒携带者，定义为50岁的老年人 在美国所有艾滋病毒携带者中，年龄较大的人几乎占到了一半。尽管预期寿命已经 艾滋病毒携带者年龄越大，身心健康和心理健康的风险就越大 与未感染的老年人相比，负担更大。有充分的证据表明，艾滋病毒携带者的人数正在增加 认知受损的风险，包括导致痴呆症和阿尔茨海默病的认知障碍，以及 艾滋病毒相关性神经认知障碍(手)。其中认知障碍的后果 人口对人口和公共健康有着深远的影响。受损的个人可能会失去 能够充分参与艾滋病毒护理方面的活动，例如坚持抗逆转录病毒疗法。受损的 个人也可能失去充分参与其他健康促进和有益行为的能力，例如 参加体育和休闲活动，激活或利用社会支持等积极资源， 生活的目标，以及经济来源。放在更广泛的生命历程背景下，拥有多重生活 应激源也可能对从事健康行为的能力、资源和影响产生负面影响 认知结果。然而，研究还没有理清认知对参与的影响。 在积极利用资源的背景下，艾滋病毒携带者老年人的健康行为。一个更伟大的 鉴于艾滋病毒携带者和相应公众的老龄化，需要了解这一点 健康负担。拟议的职业发展奖(K01)的总体目标是调查 认知缺陷与健康促进行为的关系，阐明积极的调节作用 资源，并确定这些互动对老年人生活质量的累积影响 在与艾滋病毒携带者生活时感受到压力。这将通过完成拟议的培训来实现。 计划，按认知、艾滋病毒和老龄化、生物统计和纵向四个内容领域组织 研究设计，专业发展。该培训计划的设计目标是启动 派作为一名独立调查员的职业生涯，有一个专注于认知相互作用的研究项目， 心理社会因素，生活压力对健康和成功老龄化的影响。

PROJECT SUMMARY/ABSTRACT Advancements in therapy have drastically improved life expectancy for people living with HIV and many individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this population have far reaching implications for population and public health. Impaired individuals may lose the ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as participate in physical and leisure activities, and activate or utilize positive resources like social support, purpose in life, and financial resources. Taken within a broader life course context, having multiple life stressors may also negatively impact the ability to engage in health behaviors and resources and influence cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater understanding of this is needed given the aging of the population living with HIV and the corresponding public health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive resources, and to determine the cumulative impact of these interactions on quality of life for older adults experiencing stress while living with HIV. This will be achieved through the completion of the proposed training plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal research design, and professional development. This training plan was designed with the goal of launching the PI’s career as an independent investigator with a research program focused on the interplay of cognition, psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.