Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

项目总结/摘要 治疗的进步大大提高了艾滋病毒感染者的预期寿命， 人们都能很好地活到老年。老年艾滋病毒感染者，定义为50岁以上的人 年龄较大的人几乎占美国艾滋病毒感染者的一半。尽管预期寿命 随着艾滋病毒感染者人数的增加，老年人在身体、精神和心理健康方面面临的风险更大。 与未受感染的老年人相比。有充分的证据表明，艾滋病毒感染者的人数在增加， 认知受损的风险，包括导致痴呆和阿尔茨海默病的认知障碍，以及 HIV相关的神经认知障碍（HAND）。认知障碍的后果 人口问题对人口和公共卫生有着深远的影响。受损的人可能会失去 有能力充分参与艾滋病毒护理活动，如坚持抗逆转录病毒疗法。受损 个人也可能失去充分参与其他健康促进和有益行为的能力， 参与体育和休闲活动，并激活或利用积极的资源，如社会支持， 生活的目的和经济来源。在更广泛的生命历程背景下，具有多重生命 压力源也可能对参与健康行为和资源的能力产生负面影响， 认知结果。然而，研究还没有解开认知对参与的影响， 健康的行为在积极的资源利用的背景下，在老年人与艾滋病毒。更大 考虑到艾滋病毒感染者和相应公众的老龄化， 健康负担。职业发展奖（K 01）的总体目标是调查 认知缺陷与健康促进行为之间的关系，阐明了积极的认知缺陷对健康促进行为的调节作用。 资源，并确定这些相互作用对老年人生活质量的累积影响 在感染艾滋病毒的同时承受压力。这将通过完成拟议的培训来实现 计划，根据认知，艾滋病毒和老龄化，生物统计学和纵向四个内容领域组织 研究设计和专业发展。本培训计划旨在启动 PI作为一名独立调查员的职业生涯，其研究项目专注于认知的相互作用， 心理社会因素和生活压力对健康和成功老龄化的个人老龄化与艾滋病毒。

PROJECT SUMMARY/ABSTRACT Advancements in therapy have drastically improved life expectancy for people living with HIV and many individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this population have far reaching implications for population and public health. Impaired individuals may lose the ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as participate in physical and leisure activities, and activate or utilize positive resources like social support, purpose in life, and financial resources. Taken within a broader life course context, having multiple life stressors may also negatively impact the ability to engage in health behaviors and resources and influence cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater understanding of this is needed given the aging of the population living with HIV and the corresponding public health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive resources, and to determine the cumulative impact of these interactions on quality of life for older adults experiencing stress while living with HIV. This will be achieved through the completion of the proposed training plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal research design, and professional development. This training plan was designed with the goal of launching the PI’s career as an independent investigator with a research program focused on the interplay of cognition, psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.