Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

项目概要/摘要 治疗方法的进步极大地提高了艾滋病毒感染者和许多人的预期寿命 人们都生活在老年期。感染艾滋病毒的老年人，定义为 50 岁以上的人 和老年人，几乎占美国所有艾滋病毒感染者的一半。尽管预期寿命已 感染艾滋病毒的老年人在身体、精神和社会心理等多种方面面临更大的健康风险 与未感染的老年人相比，负担更大。有充分证据表明，艾滋病毒感染者的患病率有所增加 认知受损的风险，包括导致痴呆和阿尔茨海默病的认知障碍，以及 HIV 相关神经认知障碍 (HAND)。认知障碍的后果 人口对人口和公共卫生具有深远影响。受损的个人可能会失去 充分参与艾滋病毒护理活动的能力，例如坚持抗逆转录病毒治疗。受损 个人也可能失去充分参与其他健康促进和有益行为的能力，例如 参加体育和休闲活动，激活或利用积极的资源，如社会支持、 人生目标和财务资源。在更广泛的生命历程背景下，拥有多重生命 压力源还可能对参与健康行为和资源的能力产生负面影响，并影响 认知结果。然而，研究尚未阐明认知对参与度的影响。 感染艾滋病毒的老年人在积极利用资源的背景下的健康行为。一个更大的 鉴于艾滋病毒感染者人口的老龄化以及相应的公众，需要了解这一点 健康负担。拟议的职业发展奖（K01）目标的总体目标是调查 认知缺陷与健康促进行为之间的关系，阐明积极的调节作用 资源，并确定这些相互作用对老年人生活质量的累积影响 感染艾滋病毒时经历压力。这将通过完成拟议的培训来实现 计划，根据认知、艾滋病毒和老龄化、生物统计学和纵向四个内容领域组织 研究设计和专业发展。制定本次培训计划的目的是为了 PI 的职业生涯是作为一名独立调查员，其研究项目专注于认知的相互作用， 心理社会因素以及生活压力对艾滋病毒感染者健康和成功老龄化的影响。

PROJECT SUMMARY/ABSTRACT Advancements in therapy have drastically improved life expectancy for people living with HIV and many individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this population have far reaching implications for population and public health. Impaired individuals may lose the ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as participate in physical and leisure activities, and activate or utilize positive resources like social support, purpose in life, and financial resources. Taken within a broader life course context, having multiple life stressors may also negatively impact the ability to engage in health behaviors and resources and influence cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater understanding of this is needed given the aging of the population living with HIV and the corresponding public health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive resources, and to determine the cumulative impact of these interactions on quality of life for older adults experiencing stress while living with HIV. This will be achieved through the completion of the proposed training plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal research design, and professional development. This training plan was designed with the goal of launching the PI’s career as an independent investigator with a research program focused on the interplay of cognition, psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.