Administrative Core

梁抽象：核心A 两国早期哮喘和微生物组研究(BEMS)项目旨在调查 在图森出生的儿童中，产前和早期接触微生物对哮喘相关结局的风险的作用， 亚利桑那州和墨西哥的诺加莱斯。完成这一两国研究议程需要一个基础设施， 将有效地管理赠款，协调所有努力，促进沟通，并协助传播 信息。行政核心(核心A)的目标是为 通过实施管理结构来管理BEMS方案项目，该结构将允许 来自所有项目和核心的调查人员将重点放在科学努力上。核心A将提供高水平 协调跨学科科学小组，以确保BEMS计划的协同作用，并将协助 所有BEAM组件的组织需求，以确保满足关键计划里程碑。具体的 行政核心的目标是：1)管理日常行政细节和方案 通过提供财务管理、管理分包合同、确保 满足美国和墨西哥的监管要求，并根据计划目标监测进展情况；2) 建立一个基础设施，以促进项目、核心和调查员之间以及 与NIH的项目主管(PD)合作，并在必要时提供冲突解决方案；以及3)协助 及时向地方和全国科学界传播研究成果，以及 向公众提供信息，包括研究参与者。对于这些任务，核心A项目管理 员工在成功组织和管理复杂多组件方面拥有数十年的经验 在核心主任费尔南多·马丁内斯博士的指导下开展的项目。就项目1和核心B而言， 行政核心将促进与启动出生队列有关的活动，包括旅行 调查人员，安排与两国小组的会议，培训研究人员，并确保 符合跨境运送标本和两国人类受试者的法规要求 研究。对于项目2，核心A将促进分包合同的协调和与调查人员的会议 在加州大学旧金山分校。对于项目3，核心A将确保所有与动物研究有关的大学法规 相遇了。它还将与其人员一起为核心D的数据管理和分析提供行政支助 来自不同的单位和机构。最后，核心A将与咨询委员会成员保持联系 并组织董事会年度会议。通过这些努力，核心A将创建和维护 行政基础设施，以确保成功完成这一跨学科的两国方案。

BEAMS ABSTRACT: Core A The Binational Early Asthma and Microbiome Study (BEAMS) Program Project is designed to investigate the role of prenatal and early life microbial exposures on risk for asthma-related outcomes in children born in Tucson, Arizona and in Nogales, Mexico. Accomplishing this binational research agenda requires an infrastructure that will effectively administer the grant, coordinate all efforts, foster communication and assist with dissemination of information. The goal of the Administrative Core (Core A) is to provide a central resource for administering the BEAMS Program Project by implementing a management structure that will allow investigators from all projects and cores to focus on the scientific effort. Core A will provide high level coordination of transdisciplinary scientific groups to ensure BEAMS program synergy and will assist with the organizational needs of all BEAMS components to assure that critical program milestones are met. The specific aims of the Administrative Core are to: 1) Manage the day-to-day administrative details and programmatic needs of the BEAMS program by providing fiscal management, administering subcontracts, assuring that regulatory requirements in the US and Mexico are met, and monitoring of progress with program objectives; 2) Create an infrastructure to facilitate communication between the projects, cores and investigators, and of the Program Directors (PD) with NIH, and provide for conflict resolution should it be necessary; and 3) Assist with dissemination of research findings in a timely fashion to the scientific community, both locally and nationally, and provide information to the public, including study participants. To these tasks, the Core A project management staff brings decades of experience in successful organization and management of complex multi-component projects under the direction of Dr. Fernando Martinez, the Core Director. For Project 1 and Core B, the Administrative Core will facilitate activities related to the initiation of the birth cohort, including travel of investigators, scheduling of meetings with the binational team, training of research staff and assuring that regulatory requirements are met for transport of specimens across the border and binational human subjects research. For Project 2, Core A will facilitate coordination of subcontracts and meetings with the investigators at UCSF. For Project 3, Core A will assure all university regulations pertaining to research with animals are met. It will also provide administrative support for data management and analysis in Core D with its personnel from different units and institutions. Finally, Core A will maintain contact with members of the Advisory Board and organize the Board’s annual meetings. Through these efforts, Core A will create and maintain the administrative infrastructure to ensure successful completion of this transdisciplinary, binational program.