Core B: Biostatistics/Bioinfomatics Core

核心 B：生物统计学/生物信息学核心

• 批准号: 10653101
• 负责人: Jingqin Luo
• 金额: $ 26.77万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653101
• 关键词: Ally; Animals; Bioinformatics; Biometry; Clinic; Clinical; Clinical Research; Communication; Comprehensive Cancer Center; Computational Biology; Consultations; Data; Data Analyses; Data Science; Data Security; Data Set; Database Management Systems; Databases; Development; Ensure; Equipment and supply inventories; Experimental Designs; Experimental Models; Faculty; Formulation; Foundations; Glioma; Goals; Grant; Hospitals; Human; Human Resources; Informatics; Information Dissemination; Infrastructure; Institution; Investments; Lead; Leadership; Manuscripts; Medical center; Methods; Molecular Profiling; Outcome; Positioning Attribute; Reporting; Reproducibility; Research; Research Design; Research Personnel; Resources; Secure; Sex Differences; Specimen; The Cancer Genome Atlas; Translational Research; Universities; University Hospitals; Washington; Work; Writing; analytical method; central database; data management; design; experimental study; innovation; large datasets; programs; sex; single cell sequencing; skills; success

PROJECT SUMMARY The Program Project (P01) Biostatistics/Bioinformatics Core (BBC) will interact with all P01 investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. The Core will work closely with investigators to ensure that research questions lead to experiments with quantifiable goals and testable hypotheses. In addition, the Core will provide infrastructure and oversight for secure management of all study data (whether from publically available resources or generated as part of this P01), working closely with the Cores to facilitate accuracy and completeness of datasets for all projects and investigators. This will be accomplished through the following aims: 1) To support all P01 investigators in the study design, conduct, analysis, and reporting of results from all studies and 2) To provide secure and accessible database systems to facilitate reliable and reproducible analysis of results from the experiments conducted by all P01 investigators. The BBC serves as a centralized resource for all investigators involved in the P01, including all Projects and other Cores. The Core will assist investigators with all facets of study design, analysis, and interpretation, including appropriately powering experimental studies for sex differences. Established and innovative analytic methods are available to promote scientific discovery. Core personnel will interact with P01 investigators in all stages of research, from the formulation of the research questions, through experimental design, data management, data analysis (including outcomes analysis), interpretation, writing scientific manuscripts, to dissemination of results. The Core will also facilitate access to large datasets, whether from publically available resources (TCGA and other publically available -omic data) or generated as part of this P01 through bulk and single-cell sequencing in order to validate sex-specific molecular signatures and features identified in this P01. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with animal and biospecimen data as provided by the Experimental Models Core. The Core will provide a natural foundation for cross-pollination among the Projects and Cores. The BBC is integral to all components of the P01. We will be performing data management, statistical/bioinformatics consultation and interpretation of results as well as assisting with manuscripts/grants, throughout the entire grant period. Regular communication with the Administrative Core will be maintained in order to ensure tracking and management of all Projects and Cores. The BBC will work closely with the Experimental Models Core to assist with inventory of and tracking of use of specimens (animal and human) and merging of clinical and experimental information on all specimens used for all projects (including bulk and single-cell sequencing data). In addition, the Core will assist with assurance of reproducible best practices for all Projects and Cores. !

项目摘要 计划项目（P01）生物统计学/生物信息学核心（BBC）将与所有P01研究者互动， 开发和应用适当的分析方法和设计，以最有效地实现项目目标。核心 我将与研究人员密切合作，以确保研究问题导致可量化目标的实验 和可检验的假设此外，核心将为安全管理提供基础设施和监督 所有研究数据（无论是来自临床可用资源还是作为本P01的一部分生成）， 以促进所有项目和研究人员数据集的准确性和完整性。这将是 通过以下目的实现：1）在研究设计、实施 分析和报告所有研究的结果，以及2）提供安全和可访问的数据库系统， 有助于对所有P01研究者进行的实验结果进行可靠和可重复的分析。 英国广播公司作为一个集中的资源，为所有调查人员参与P01，包括所有项目， 其他核心核心将协助研究者进行研究设计、分析和解释的各个方面， 包括为性别差异的实验研究提供适当的动力。成熟和创新的分析 有方法可以促进科学发现。核心人员将与P01研究者在所有 研究阶段，从研究问题的制定，通过实验设计，数据 管理，数据分析（包括结果分析），解释，撰写科学手稿， 传播成果。该核心还将促进对大型数据集的访问，无论是从可获得的 资源（TCGA和其他可用的组织学数据）或作为本P01的一部分通过批量和 单细胞测序，以验证本P01中鉴定的性别特异性分子特征和特征。 核心小组将协助所有调查人员开发、管理其项目数据并确保其可靠性， 还可以整合数据库中的信息，例如将临床和实验数据与动物实验数据相结合。 以及实验模型核心提供的生物样本数据。内核将提供一个天然的基础 项目和核心之间的交叉授粉。BBC是P01所有组件的组成部分。我们将 进行数据管理、统计/生物信息学咨询和结果解释，以及 在整个赠款期间协助手稿/赠款。定期与 将维护行政核心，以确保跟踪和管理所有项目和核心。 英国广播公司将与实验模型核心密切合作，协助库存和跟踪使用 样本（动物和人类），并合并所有样本的临床和实验信息 所有项目（包括批量和单细胞测序数据）。此外，核心将协助确保 适用于所有项目和核心的可复制最佳实践。 !