Core B: Biostatistics/Bioinfomatics Core

项目总结 计划项目(P01)生物统计/生物信息学核心(BBC)将与所有P01调查人员互动，以 开发和应用适当的分析方法和设计，以最有效地实现项目目标。《核心》 将与调查人员密切合作，确保研究问题导致具有可量化目标的实验 和可检验的假设。此外，核心将为安全管理提供基础设施和监督 所有研究数据(无论是来自公共可用的资源还是作为本P01的一部分产生)，密切合作 使用核心，以促进所有项目和调查人员的数据集的准确性和完整性。这将是 通过以下目标完成：1)支持所有P01研究人员进行研究设计、实施、 分析和报告所有研究的结果；2)提供安全和可访问的数据库系统，以 促进对所有P01调查人员进行的实验结果进行可靠和可重复性的分析。 BBC是参与P01的所有调查人员的集中资源，包括所有项目和 其他核心。核心将协助研究人员进行研究设计、分析和解释的所有方面， 包括适当推动性别差异的实验研究。建立和创新的分析 促进科学发现的方法是可用的。核心人员将与P01调查人员全面互动 研究阶段，从研究问题的表述，到实验设计、数据 管理、数据分析(包括结果分析)、解释、撰写科学手稿 传播成果。核心还将促进对大型数据集的访问，无论是从公共可用的 资源(TCGA和其他公开可用的数据)或作为本P01的一部分通过批量和 单细胞测序，以验证本P01中确定的性别特定的分子签名和特征。 核心将协助所有调查人员开发、管理和可靠性其项目数据，并将 还可以跨数据库集成信息，例如将临床和实验数据与动物相结合 和由实验模型核心提供的生物谱数据。核心将提供一个天然的基础 用于在项目和岩心之间进行异花授粉。BBC是P01所有组件不可或缺的一部分。我们会 进行数据管理、统计/生物信息学咨询和结果解释以及 在整个赠款期间，协助撰写稿件/赠款。定期与 将维持行政核心，以确保跟踪和管理所有项目和核心。 BBC将与实验模型核心密切合作，协助清点和跟踪使用 标本(动物和人)以及临床和实验信息的合并 所有项目(包括批量和单细胞测序数据)。此外，核心将协助保证 适用于所有项目和核心的可复制最佳做法。 好了！

PROJECT SUMMARY The Program Project (P01) Biostatistics/Bioinformatics Core (BBC) will interact with all P01 investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. The Core will work closely with investigators to ensure that research questions lead to experiments with quantifiable goals and testable hypotheses. In addition, the Core will provide infrastructure and oversight for secure management of all study data (whether from publically available resources or generated as part of this P01), working closely with the Cores to facilitate accuracy and completeness of datasets for all projects and investigators. This will be accomplished through the following aims: 1) To support all P01 investigators in the study design, conduct, analysis, and reporting of results from all studies and 2) To provide secure and accessible database systems to facilitate reliable and reproducible analysis of results from the experiments conducted by all P01 investigators. The BBC serves as a centralized resource for all investigators involved in the P01, including all Projects and other Cores. The Core will assist investigators with all facets of study design, analysis, and interpretation, including appropriately powering experimental studies for sex differences. Established and innovative analytic methods are available to promote scientific discovery. Core personnel will interact with P01 investigators in all stages of research, from the formulation of the research questions, through experimental design, data management, data analysis (including outcomes analysis), interpretation, writing scientific manuscripts, to dissemination of results. The Core will also facilitate access to large datasets, whether from publically available resources (TCGA and other publically available -omic data) or generated as part of this P01 through bulk and single-cell sequencing in order to validate sex-specific molecular signatures and features identified in this P01. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with animal and biospecimen data as provided by the Experimental Models Core. The Core will provide a natural foundation for cross-pollination among the Projects and Cores. The BBC is integral to all components of the P01. We will be performing data management, statistical/bioinformatics consultation and interpretation of results as well as assisting with manuscripts/grants, throughout the entire grant period. Regular communication with the Administrative Core will be maintained in order to ensure tracking and management of all Projects and Cores. The BBC will work closely with the Experimental Models Core to assist with inventory of and tracking of use of specimens (animal and human) and merging of clinical and experimental information on all specimens used for all projects (including bulk and single-cell sequencing data). In addition, the Core will assist with assurance of reproducible best practices for all Projects and Cores. !