Identifying interconnections of the disparities in childhood obesity

项目总结/摘要： 儿童肥胖是一个严重的问题，特别是在低识字率和低收入人口中， 少数民族儿童。肥胖儿童患2型糖尿病、心血管疾病、癌症的风险较高， 哮喘和更严重的2019冠状病毒病（COVID-19）结果。大约36%的儿童生活在贫困中， 42%生活在低收入家庭。在家长教育方面也存在种族和族裔差异。40.4%的 非西班牙裔白色儿童的父母受过大学教育，而非西班牙裔黑人儿童的这一比例为20.3%。的 非洲裔美国人的肥胖率为24.2%，白人为16.1%。非洲裔美国成年人被发现 比白种人有更高的氧化应激。几种挥发性有机化合物（VOC）是由 活性氧物质。然而，直接研究与 种族差异与氧化应激和挥发性有机化合物。 本研究的总体目标是确定尿氧化应激、挥发性 有机化合物谱和氧化应激衍生的VOC代谢物与种族/民族和儿童 肥胖我们计划通过追求以下具体目标来实现本申请的目的。（一） 确定与尿中氧化应激、VOC代谢物和氧化应激相关的VOC， 儿童肥胖的种族/民族差异。(2)确定氧化应激是否诱导VOC的释放 代谢物。 这项研究将从根本上推进我们对氧化应激之间关系的理解， 以及挥发性有机化合物代谢产物与儿童肥胖的差异。这些发现将有助于 揭示了儿童肥胖差异的早期代谢非侵入性生物标志物。我们坚信 从事该项目的本科生和研究生获得的直接研究经验将 帮助他们了解与儿童肥胖差异相关的病理生理学。成功 完成这项研究将有助于参与的学生深入了解差距， 未来的科学家在健康相关学科追求自己的职业生涯。

PROJECT SUMMARY/ABSTRACT: Childhood obesity is a serious concern, particularly in low literacy and low-income populations among minority children. Obese children are at higher risk of developing type 2 diabetes, cardiovascular disease, cancer, asthma, and worse coronavirus disease 2019 (COVID-19) outcomes. Around 36% of children live in poverty, and 42% live in low-income families. There are also racial and ethnic disparities in parent education. 40.4% of non-Hispanic white children have a college-educated parent, compared with 20.3% of non-Hispanic black. The rate of obesity in African Americans is 24.2%, and in whites is at 16.1%. African American adults are found to have high oxidative stress than Caucasians. Several volatile organic compounds (VOCs) are generated by the reactive oxygen species. However, there is significant gap in the research directly examining the association of racial disparities with oxidative stress and VOCs. The overall objective of this study is to determine the association of urinary oxidative stress, volatile organic compounds profile, and oxidative stress-derived VOC metabolites with race/ethnicity and childhood obesity. We plan to accomplish the objective of this application by pursuing the following specific aims. (1) Determine the urinary oxidative stress, VOC metabolites, and oxidative stress-derived VOCs associated with race/ethnic disparity in childhood obesity. (2) Determine if oxidative stress induces the release of VOC metabolites. This research will fundamentally advance our understanding of the association between oxidative stress and the volatile organic compound metabolites with the disparities in childhood obesity. The findings will help reveal the early metabolic non-invasive biomarkers of disparities in childhood obesity. We strongly believe that the direct research experience gained by the undergraduate and graduate students working on this project will help them understand the pathophysiology associated with the disparities in childhood obesity. The successful completion of the study will help the involved students to gain in-depth knowledge of disparities and prepare future scientists to pursue their careers in health-related disciplines.