Mechanisms of Disease

疾病机制

• 批准号: 10654560
• 负责人: Thomas Joseph Carroll
• 金额: $ 19.43万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654560
• 关键词: Disease

PROJECT SUMMARY/ABSTRACT The Mechanisms of Disease and Translational Science (MoD) Track at the University of Texas Southwestern Medical Center (UTSW) will provide PhD students with core competencies needed to successfully engage in translational research and prepare them for rewarding careers in biomedical research. We will annually appoint 6 first year PhD students for 12 months each. We target this junior population to “imprint” them with the translational science mindset, and to provide iterative long term active training to enable them to seek interdisciplinary collaborations. Rationale. Accelerating the translation of basic biomedical science discoveries to tangible improvements in human health is a national priority. This need is now particularly urgent with the current explosion of scientific and technological discoveries. Mission: MoD will train a new breed of PhD translational scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Our students will be prepared to transition into the biomedical research workforce in multiple professional capacities and to spearhead the bidirectional and interdisciplinary translation of discoveries from the “bench to bedside and back” to improve human health. Objective: Create an innovative and rigorous curriculum to foster critical thinking, rigorous and ethical research design, interdisciplinary team science, and diversity and inclusion. Students will be equipped with both the “intellectual” and “practical” skills to succeed during training and in their future careers. Program Design: MoD is a “supplemental” track overlaid on the 11 existing PhD graduate programs. Our innovative and rigorous curriculum, intense multi- tiered mentoring and career development programs will allow students to achieve a full menu of competencies required to conduct rigorous translational research and to succeed. Students will be immersed in unique opportunities to study human diseases at the interface between basic and clinical sciences. They will be exposed to clinical translational science through small group learning, structured experiences in patient care, and immersion in clinical research. MoD will foster student career development, by offering experiential training in team science, grant writing, leadership, entrepreneurship and communications. Students are required to design and execute the “bench to bedside & back” mini-internship with clinicians in their third year, and are encouraged to seek additional internships to “test-drive” potential future careers. Additionally, our translational science work-in-progress format will bring together a diverse cross-section of clinical and translational trainees and researchers operating across the T0-T4 translational science spectrum. These interactions will promote exchange of ideas and accelerate bidirectional translation. Anticipated outcomes include increasing student engagement in translational research, as measured by grants, publications, time to degree, interdisciplinary collaborations, and career placement. Our MoD plan is innovative, sustainable, and cost-effective. MoD has an eleven-year history of success, and will leverage multiple institutional resources to ensure future success.

项目总结/摘要 疾病的机制和转化科学（MOD）轨道在得克萨斯州西南大学 医学中心（UTSW）将为博士生提供成功参与所需的核心能力 转化研究，并准备他们在生物医学研究的奖励职业。我们将每年任命 6名一年级博士生，每人12个月。我们针对这些年轻人， 转化科学的心态，并提供迭代的长期积极的培训，使他们能够寻求 跨学科合作。理由。加速基础生物医学科学发现的转化 切实改善人类健康是国家的优先事项。这一需要现在特别迫切， 科学和技术发现的爆炸性增长。使命：国防部将培养新一代博士 翻译科学家能够针对他们的研究计划，以解决未满足的治疗和 未来的诊断需求。我们的学生将准备过渡到生物医学研究 拥有多种专业能力的工作人员，并带头进行双向和跨学科翻译 从实验室到床边再到背部的各种发现，以改善人类健康。目的：创造创新 严谨的课程，以培养批判性思维，严谨和道德的研究设计，跨学科团队 科学、多样性和包容性。学生将同时具备“智力”和“实践”技能 在培训和未来的职业生涯中取得成功。计划设计：国防部是一个“补充”轨道 覆盖现有的11个博士研究生课程。我们的创新和严谨的课程，激烈的多- 分层指导和职业发展计划将使学生获得全面的能力 进行严格的转化研究并取得成功。学生将沉浸在独特的 在基础科学和临床科学之间的界面上研究人类疾病的机会。他们将 通过小组学习接触临床转化科学，在病人护理方面有结构化的经验， 沉浸在临床研究中国防部将通过提供体验式培训， 在团队科学，拨款写作，领导力，创业精神和沟通。要求学生 设计和执行“板凳到床边和背部”微型实习与临床医生在他们的第三年， 鼓励他们寻找更多的实习机会，以“测试”未来的潜在职业。此外，我们的翻译 科学工作的进展形式将汇集临床和翻译学员的不同横截面 以及在T0-T4转化科学领域工作的研究人员。这些互动将促进 交流思想，加速双向翻译。预期成果包括增加学生人数 参与翻译研究，通过赠款，出版物，学位时间，跨学科 合作和职业安置。我们的国防部计划是创新的、可持续的和具有成本效益的。国防部有一个 11年的成功历史，并将利用多种机构资源，以确保未来的成功。

项目成果

Tryptophan and its metabolites in normal physiology and cancer etiology.

• DOI: 10.1111/febs.16245
• 发表时间: 2023-01
• 期刊: The FEBS journal

Base and Prime Editing in the Retina-From Preclinical Research toward Human Clinical Trials.

• DOI: 10.3390/ijms232012375
• 发表时间: 2022-10-16
• 期刊: International journal of molecular sciences
• 影响因子: 5.6