Clinical and Translational Science Award

项目概要/摘要 在CTSA 3.0中，由本补充应用的母公司奖（5 UL 1 TR 001436 -08）支持，我们有 继续在威斯康星州东南部追求临床和转化研究的转型。这 包括完善熟练和创新的基础设施，以支持CT研究和科学， 消除妨碍开展高影响力研究的障碍。我们目前的奖项的一个主要重点是 关于团队科学，包括开发综合临床和研究合奏（ICRE），其中 患者、临床研究者、转化研究者、卫生系统代表、社区成员， 而其他人则被“一起”来将这些人发现的问题转化为可测试的问题 可能导致临床/转化科学研究/试验的假设、新过程或方法， 以改善患者和社区健康。本行政补充文件将支持创建 a围手术期ICRE重点改善有COVID-19病史患者的手术护理，包括 SARS-CoV-2急性后后遗症，通过利用所有 美国研究中心和国家COVID队列协作（N3 C）数据飞地。CTSA Hub的一部分 活动包括数据工作，以支持这些计划中的每一个，本补充将提供一个 有机会开展范围内项目，以回答与COVID-19大流行相关的重要问题， 包括SARS-CoV-2感染的长期后遗症，如本提案所述， 期

PROJECT SUMMARY/ABSTRACT In CTSA 3.0, supported by the parent award (5UL1TR001436-08) for this supplemental application, we have continued to pursue the transformation of clinical and translational research in southeastern Wisconsin. This includes the refinement of proficient and innovative infrastructure to support CT research and science, while removing impediments to the performance of high impact research. A major emphasis of our current award is on team science including the development of integrated clinical and research ensembles (ICREs) in which patients, clinical investigators, translational researchers, health system representatives, community members, and others are brought “All in Together” to translate problems identified by these individuals into testable hypotheses, novel processes, or methods that can lead to clinical/translational science studies/trials and solutions to improve patient and community health. This Administrative Supplement will support the creation of a Perioperative ICRE focused on improving surgical care for patients with a history of COVID-19, including Post-Acute Sequelae of SARS-CoV-2, using precision medicine techniques through leveraging both the All of Us Research Hub and National COVID Cohort Collaborative (N3C) Data Enclave. Part of our CTSA Hub’s activities include data efforts to support each of these programs and this supplement will provide an opportunity to conduct an in-scope project to answer an important question related to the COVID-19 pandemic, including the long-term sequelae of SARS-CoV-2 infection, as described in this proposal over a 12-month period.