The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network

项目摘要/摘要 佛罗里达节点联盟(FNA)旨在扩大我们在以下方面领导和实施试验的成功记录 医疗保健环境和将物质使用纳入医疗保健主流。我们建议将 FNA在青少年治疗、艾滋病毒和丙型肝炎护理方面的丰富专业知识实质上是- 使用人口、心理健康并存、电子健康、数据科学、文化科学、卫生经济学、 培训、实施/传播以及与拉美裔人口合作。FNA的研究议程将 提供科学领导，以开发、测试和实施针对全光谱物质的干预措施 在青少年和成人中的使用，以及整合SU预防/筛查/治疗服务的战略 纳入主流的青少年和成人保健服务。FNA还旨在将我们的专业知识应用于实施 科学、数据科学和使用电子健康记录(EHR)来促进学习卫生保健 建立在精确医学原则基础上的系统，通过实施和改进方法来预测个体 对治疗的反应。在双向合作的基础上，FNA建议发展， 测试并实施干预措施，以解决FNA临床和 研究网络。这些网络包括SUD治疗和普通医疗机构、卫生系统、 临床研究网络和基于实践的研究网络。为了实现其目标，FNA提议 (1)将行为健康和以家庭为重点的概念相结合的创新研究议程 利用电子技术干预儿科护理，(2)提供共病护理的综合模式 SU和艾滋病毒在医院环境中，(3)解决精神健康和兴奋剂使用的共病，(4)使用EHR， 登记和环境数据，以提高处理精度；以及(5)利用背景和文化来改进 治疗结果。FNA建议与其他节点合作设计和实施 CTN试验，并提供成功执行研究所需的基础设施和能力。FNA 网络合作伙伴在实施护理点试验和研究方面表现出了经验，这些试验和研究利用 使用电子病历和索赔数据。迈阿密大学CTSI、佛罗里达大学CTSI和佐治亚州CTSA 将把CTSA国家联盟的生物信息学工具带给CTN。这些CTSA连同 FNA的合作伙伴，促进接触到众多不同的1600万患者群体 初级保健、急诊室、医院、FQHC、以学校为基础的诊所、SUD治疗和伤害等环境 减肥场。

PROJECT SUMMARY/ABSTRACT The Florida Node Alliance (FNA) aims to build on our record of success in leading and implementing trials in healthcare settings and integrating substance use into mainstream of healthcare. We propose to bring to the CTN the FNA’s considerable expertise in adolescent treatment, the HIV and HCV care continua in substance- using populations, mental health comorbidities, e-Health, data science, culturalized science, health economics, training, implementation/dissemination, and work with Hispanic populations. The FNA’s research agenda will provide scientific leadership to develop, test, and implement interventions for the full spectrum of substance use in adolescents and adults, and strategies for the integration of SU prevention/screening/treatment services into mainstream adolescent and adult health care. The FNA also aims to apply our expertise in implementation science, data science, and the use of electronic health records (EHRs) to promote learning health care systems that build on precision medicine principles by implementing and refining methods to predict individual response to treatment. Building on a foundation of bidirectional collaboration, the FNA proposes to develop, test, and implement interventions that address the service delivery continuum in the FNA’s clinical and research networks. These networks consist of SUD treatment and general medical settings, health systems, clinical research networks, and practice-based research networks. To achieve its aims, the FNA is proposing an innovative research agenda of concepts that (1) integrate behavioral health and family-focused interventions in pediatric care with the use of e-technologies, (2) deliver integrative models of care for comorbid SU and HIV in hospital settings, (3) address the comorbidities of mental health and stimulant use, (4) use EHR, registry and environmental data to improve treatment precision, and (5) use context and culture to improve treatment outcomes. The FNA proposes to collaborate with other Nodes on the design and implementation of CTN trials and by providing the infrastructure and capabilities required for successful study execution. FNA network partners have demonstrated experience in conducting point of care trials and studies that leverage the use of EHR and claims data. The University of Miami CTSI, University of Florida CTSI, and the Georgia CTSA will bring to the CTN the bioinformatics tools of the CTSA National Consortium. These CTSAs together with partners of the FNA, facilitate access to a diverse patient population of 16+ million patients across numerous settings such as primary care, EDs, hospitals, FQHCs, school-based clinics, SUD treatment, and harm reduction venues.