NP-MRD: Natural Products Magnetic Resonance Database

NP-MRD：天然产物磁共振数据库

• 批准号: 10655369
• 负责人: JOHN R CORT
• 金额: $ 81.51万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655369
• 关键词: Acceleration; Agreement; Animals; Archaea; Archives; Atlases; Bacteria; Chemicals; Classification; Cloud Computing; Communities; Complement; Complex Mixtures; Computer software; Consensus; Crude Extracts; Data; Data Storage and Retrieval; Databases; Deposition; Disease; Ensure; FAIR principles; Frequencies; Gene Cluster; Goals; Harvest; Health; Hour; Human; Humanities; Image; Individual; Intuition; Journals; Learning; Letters; Link; Literature; Magnetic Resonance; Mass Spectrum Analysis; Media Campaign; Metadata; Methods; Mining; Molecular; NMR Spectroscopy; National Center for Complementary and Integrative Health; Natural Products; Newsletter; Nuclear Magnetic Resonance; Online Systems; Paper; Plants; Policies; Printing; Privatization; Process; Protocols documentation; Publications; Reporting; Research; Resolution; Resources; Retrieval; Running; Scientific Societies; Scientist; Sister; Site; Social Network; Software Tools; Source; Structure; Summary Reports; Taxonomy; Techniques; Text; Time; Traction; Training; Translations; Validation; Vendor; Visualization; Visualization software; Work; cloud based; community engagement; computing resources; data archive; data exchange; data format; data integrity; data quality/integrity; data repository; data sharing; data submission; density; design; digital object identifier; expectation; experimental study; fungus; heuristics; improved; interactive tool; interoperability; marine organism; metabolome; metabolomics; novel; open data; open source; outreach; public database; quantum; query tools; repository; simulation; social; social media; symposium; theories; tool; user-friendly; web site; web-enabled; webinar

PROJECT SUMMARY This project will develop the Natural Products Magnetic Resonance Database (NP-MRD), the central repository for all NMR data generated by the natural products community. The core of the NP-MRD will be an open-access, web-enabled, community-focused, FAIR-compliant database containing NMR spectra and structures for all known natural products (estimated to be ~350,000 structures). It will contain (i) legacy (curator-backfilled) NMR data of NPs derived from the literature, existing public databases, and “private” data archives, (ii) new NMR data submitted by depositors for novel NPs, and (iii) heuristically calculated NMR chemical shifts for all NPs and, eventually, density functional theory (DFT) calculated chemical shifts all NPs. Data deposition will be both rapid (<5 minutes) and simple. The NP-MRD will be closely integrated (through data exchange agreements) with “sister” databases containing MS, biosynthetic gene cluster, and bioactivity data. It will provide rigorous validation and data checking (QA/QC) to ensure that submitted assignment data is of the highest quality. Validation and analytical summary reports will be provided following data deposition. The NP-MRD will also offer powerful database search, filtering, and querying tools to facilitate spectral, structure and taxonomic searches or selections. In addition to data storage, retrieval, and curation, the NP-MRD will host an extensive suite of software tools for NP research. These will include tools for spectral dereplication, structure validation, and NMR-based profiling of complex mixtures. The NP-MRD will also provide tools for spectral and structural visualization and comparison, as well as chemical-space network visualization and chemo-taxonomic comparisons. Additionally the NP-MRD will offer tools for NMR spectral prediction and simulation. A core principle of the NP-MRD is that availability of high-quality, value-added reporting and interactive tools will encourage user engagement and data deposition. Software produced and hosted by the NP-MRD will be open-source and open-access. To enhance interoperability, portions of the NP-MRD and associated software will be “dockerized” on cloud computing resources and, if needed, converted to web-based APIs. The NP-MRD’s deposition tools will be designed to work with participating journals’ paper-submission software. The NP-MRD team will engage thought leaders, journal editors, and database managers to develop consensus protocols regarding data deposition, data format standards, and data exchange—all compliant with community-established policies and standards. Our proposed work has already gained traction, as shown by many strong letters of support from key stakeholders. The NP- MRD will offer online and on-site (at conferences) training on use of its software for NP dereplication and identification. Resources covering tips, tricks, and techniques in NMR spectroscopy and NMR software will be made available on the NP-MRD website and through web-based “office hours” to help users, depositors, and the general NP community. NP-MRD’s long-term goal is to advance and enable natural products research by archiving and adding real value to natural product NMR data.

项目总结

项目成果

NP-MRD: the Natural Products Magnetic Resonance Database.

• DOI: 10.1093/nar/gkab1052
• 发表时间: 2022-01-07
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Wishart DS;Sayeeda Z;Budinski Z;Guo A;Lee BL;Berjanskii M;Rout M;Peters H;Dizon R;Mah R;Torres-Calzada C;Hiebert-Giesbrecht M;Varshavi D;Varshavi D;Oler E;Allen D;Cao X;Gautam V;Maras A;Poynton EF;Tavangar P;Yang V;van Santen JA;Ghosh R;Sarma S;Knutson E;Sullivan V;Jystad AM;Renslow R;Sumner LW;Linington RG;Cort JR
• 通讯作者: Cort JR

A Data Deposition Platform for Sharing Nuclear Magnetic Resonance Data.

共享核磁共振数据的数据沉积平台。

• DOI: 10.1021/acs.jnatprod.3c00795
• 发表时间: 2023
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Pin,Matthew;Poynton,EllaF;Jordan,Tamara;Kim,Jonghyeok;Ledingham,Benjamin;vanSanten,JeffreyA;Yang,Vera;Maras,Andrew;Tavangar,Pegah;Gautam,Vasuk;Peters,Harrison;Sajed,Tanvir;Lee,BrianL;Shreffler,HaileyA;Koller,JamesT;Tret
• 通讯作者: Tret

Microbial natural product databases: moving forward in the multi-omics era.

• DOI: 10.1039/d0np00053a
• 发表时间: 2021-01-01
• 期刊: Natural product reports
• 影响因子: 11.9
• 作者: van Santen JA;Kautsar SA;Medema MH;Linington RG
• 通讯作者: Linington RG