Using mobile technology to prevent HIV and related Youth Health problems: Sexual health, Mental health, and Substance use in southwest Uganda (Youth Health SMS)

使用移动技术预防​​艾滋病毒和相关的青少年健康问题：乌干达西南部的性健康、心理健康和药物使用（青少年健康短信）

• 批准号: 10656457
• 负责人: Philip Kreniske
• 金额: $ 17.81万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656457
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent and Young Adult; Adult; Affect; Alcohol consumption; Area; Behavior; Biological Factors; Caring; Cellular Phone; Cohort Studies; Communication; Communities; Continuity of Patient Care; Counseling; Country; Cross-Sectional Studies; Data; Data Analyses; Decision Making; Development; Epidemic; Epidemiology; Evidence based intervention; Face; Funding; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; HIV Seroprevalence; HIV risk; HIV/STD; Health; Health Professional; Healthcare; Household; Human immunodeficiency virus test; Incidence; Income; International; Intervention; Intervention Trial; Life; Manuscripts; Mediating; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentorship; Ownership; Population; Positioning Attribute; Prevention; Prevention strategy; Professional counselor; Proliferating; Psychologist; Randomized, Controlled Trials; Recommendation; Reproductive Health; Research; Research Activity; Research Personnel; Research Priority; Research Project Grants; Resources; Risk; Risk Behaviors; Risk Factors; STI prevention; Safe Sex; Schools; Services; Sex Behavior; Sexual Health; Site; Socialization; Southern Africa; Substance abuse problem; Symptoms; Technology; Testing; Training; Uganda; United States National Institutes of Health; Universities; Work; Writing; Youth; acceptability and feasibility; alcohol screening; behavioral and social science; behavioral health; career; comorbidity; design; digital; digital technology; evidence base; experience; girls; hands on research; health disparity; high risk; implementation science; improved; innovation; longitudinal analysis; low and middle-income countries; meetings; mobile computing; mobile phone based intervention; panacea; pre-exposure prophylaxis; prevent; programs; protective factors; screening; secondary analysis; sexual relationship; sexual risk behavior; skills; social; social culture; social factors; substance use; systematic review; therapy design; uptake; young woman

The proposed K01 Award will provide the candidate, Dr. Kreniske, with the skills to achieve his long-term goal of being an independent HIV investigator and an international leader who leverages digital technology to improve adolescent and young adult (AYA) uptake of HIV prevention (including PrEP and HIV testing) and linkage to behavioral health care. The candidate is a developmental psychologist with experience in qualitative and cross- sectional research, domestically and internationally. The proposed training and research experience will expand the candidate’s ability to design and evaluate interventions for AYA at high risk for HIV infection and address the high priority topic of the National Institute of Health (NIH) Office of AIDS Research (OAR) of reducing the incidence of HIV. To achieve his overall goals, Dr. Kreniske will receive additional training in: (1) longitudinal data analysis for the purposes of interpreting associations between mobile phone use and protective and risk factors for HIV infection in under-resourced settings; (2) adapting mobile phone-based interventions to address multiple HIV risk factors as they relate to HIV prevention and the HIV care cascade; (3) evaluating mobile phone- based interventions for AYA in under-resourced settings using randomized controlled trials (RCT); and (4) professional skills for a successful independent research career, including grant and manuscript writing. The candidate has assembled a mentorship team of national and international leaders who will support his successful transition to independence through coursework, directed readings, one-on-one meetings, hands-on research activities, and completion of an independent research project. Dr. Kreniske’s work is based in East and Southern Africa (ESA) where AYA have the highest rates of HIV infection worldwide. Mental health and substance use affect decision making about sexual and reproductive health and thus function as critical barriers to prevention of HIV infection. AYA, particularly in this socio-cultural context, face unique challenges in accessing counselors who can provide mental health and substance use assessment and treatment. To address these challenges the candidate will identify how technology is related to known HIV risk factors (e.g. sexual behaviors, mental health symptoms, substance use) and adapt and evaluate a mobile phone-based intervention. This will serve as proof of concept for an R01 proposal to evaluate a scalable mobile phone-based intervention to reduce HIV infection by targeting at risk AYA. Research and training will occur at NYSPI/ Columbia University as well as international sites, in affiliation with two NIH-funded studies, (1) SSTAR, a study of AYA social transitions and determinants (R01HD091003; PI Santelli), which will provide secondary data from the Rakai Community Cohort Study (RCCS), and (2) SUUBI4Her (R01MH113486; PI Ssewamala), an HIV prevention study for AYA girls in Uganda that will provide secondary data on mental health. Research findings and skills obtained during the K01 will position Dr. Kreniske to become an independent investigator who can contribute to the efforts to end the HIV epidemic through innovative interventions tailored to at risk AYA.

拟议的 K01 奖将为候选人 Kreniske 博士提供实现其长期目标的技能 成为一名独立的艾滋病毒调查员和利用数字技术改善艾滋病毒的国际领导者 青少年和年轻人 (AYA) 对艾滋病毒预防（包括 PrEP 和艾滋病毒检测）的了解以及与 行为健康护理。候选人是一位发展心理学家，在定性和跨学科方面具有丰富的经验。 国内和国际的截面研究。拟议的培训和研究经验将扩大 候选人设计和评估艾滋病毒感染高风险 AYA 干预措施并解决以下问题的能力 美国国立卫生研究院 (NIH) 艾滋病研究办公室 (OAR) 的高度优先主题是减少 艾滋病毒的发病率。为了实现他的总体目标，Kreniske 博士将接受以下方面的额外培训：(1) 纵向 数据分析，旨在解释手机使用与保护和风险之间的关联 资源贫乏地区艾滋病毒感染的因素； (2) 采用基于手机的干预措施来解决 与艾滋病毒预防和艾滋病毒护理级联相关的多种艾滋病毒风险因素； (3)评价手机—— 使用随机对照试验 (RCT) 对资源贫乏地区的 AYA 进行干预；和（4） 成功独立研究生涯的专业技能，包括资助和手稿写作。这 候选人组建了一支由国内和国际领导人组成的导师团队，他们将支持他的成功 通过课程作业、定向阅读、一对一会议、实践研究过渡到独立 活动，并完成独立研究项目。克雷尼斯克博士的工作以东部和南部为基地 非洲（ESA），AYA 是全球艾滋病毒感染率最高的地区。心理健康和物质使用 影响有关性健康和生殖健康的决策，从而成为预防的关键障碍 艾滋病毒感染。 AYA，特别是在这种社会文化背景下，在寻求咨询师方面面临着独特的挑战 谁可以提供心理健康和药物使用评估和治疗。为了应对这些挑战 候选人将确定技术如何与已知的艾滋病毒风险因素（例如性行为、心理健康 症状、物质使用）并调整和评估基于手机的干预措施。这将作为证据 R01 提案的概念，旨在评估可扩展的基于移动电话的干预措施，以减少艾滋病毒感染 通过瞄准风险 AYA。研究和培训将在 NYSPI/哥伦比亚大学以及国际机构进行 网站，与两项 NIH 资助的研究相关，(1) SSTAR，一项关于 AYA 社会转型和决定因素的研究 （R01HD091003；PI Santelli），将提供 Rakai 社区队列研究的二手数据 (RCCS) 和 (2) SUUBI4Her (R01MH113486；PI Ssewamala)，一项针对乌干达 AYA 女孩的艾滋病毒预防研究 这将提供有关心理健康的二手数据。 K01期间获得的研究成果和技能将 使克雷尼斯克博士成为一名独立调查员，为终结艾滋病毒做出贡献 通过针对高危 AYA 量身定制的创新干预措施来控制流行病。