Biostatistics & Informatics Shared Resource

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BIOSTATISTICS AND INFORMATICS SHARED RESOURCE (BISR): ABSTRACT The Biostatistics and Informatics Shared Resource (BISR) plays an essential role in the research activities of The University of Kansas Cancer Center (KUCC) by supporting the data science needs of KUCC investigators. The BISR is co-led by Byron Gajewski (CPC), PhD, and Devin Koestler (CB), PhD, both accomplished biostatisticians with a long-standing commitment to cross-disciplinary collaborations. The BISR includes 19 faculty members with specialized cancer biostatistics research expertise, 13 technical support staff and postdoctoral fellows, and three administrative staff members who provide additional technical and administrative expertise, adding efficiency to the resource. The BISR assists KUCC investigators by providing guidance and direction in study design, statistical oversight and analyses, clinical research informatics and data management, electronic data collection, bioinformatics, complex data set (statistical ‘omics) analysis, and investigator-initiated clinical trials. The BISR consists of faculty and staff whose diverse expertise and skill sets span the areas of biostatistics, bioinformatics, and informatics. The considerable overlap between these three areas allows researchers to work with a single shared resource for their data collection, analytics, and statistical analysis needs. The synergy between the areas that encompass “data science” enables the BISR to support a wide range of quality services in a timely and cost-effective manner. To support the research activities of KUCC members, the specific aims of this resource are to: 1) provide study design and statistical support and expertise; 2) provide bioinformatics and statistical genetics support and expertise; 3) provide informatics expertise for data collection and management, as well as develop and support ongoing research enabling technologies, platforms, and tools; and 4) educate students, fellows and faculty members of KUCC on data science, reproducible research ideas, and methods used in cancer research. From 2016-2020, the BISR supported 69, 60, 85, 80, and 78 KUCC members respectively. In 2020, the breakdown was 18, 33, and 27 members from Cancer Biology, Cancer Prevention and Control, and Drug Discovery, Delivery and Experimental Therapeutics, respectively, on 89 grant applications (submissions and resubmissions) and 161 projects (ongoing grants, IITs, and other projects). In addition, the BISR supported 31 non-member cancer researchers in 2020. For all cancer-related projects, the BISR supported 340 grant applications plus projects in 2020. In 2021, CCSG funding accounts for ~10% of the BISR budget, with an annual direct support return on investment of approximately $0.6M dollars in external funding to support BISR faculty and staff (31% of BISR support).