Biostatistics & Informatics Shared Resource

生物统计学

• 批准号: 10671737
• 负责人: Byron J. Gajewski
• 金额: $ 30.58万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-11 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671737
• 关键词: Address; Animals; Applications Grants; Area; Basic Science; Bioinformatics; Biometry; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Computer Analysis; Computer software; Custom; Data; Data Analyses; Data Collection; Data Reporting; Data Science; Data Set; Databases; Development; Doctor of Philosophy; Education; Educational workshop; Experimental Designs; Faculty; Frequencies; Funding; Genetic; Genomics; Goals; Grant; Human; Informatics; Information Systems; Investigational Therapies; Investments; Kansas; Leadership; Maintenance; Malignant Neoplasms; Methodology; Methods; Molecular; Outcome; Play; Postdoctoral Fellow; Quality Control; Reproducibility; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resource Informatics; Resource Sharing; Resources; Role; Services; Standardization; Statistical Data Interpretation; Students; System; Technology; Training; Translational Research; Universities; Visualization; Work; anticancer research; cancer prevention; complex data; cost effective; cost effectiveness; data cleaning; data management; design; drug discovery; electronic data; high dimensionality; improved; informatics shared resource; interest; member; novel; pre-clinical; programs; research study; skills; statistics; synergism; tool; trend

BIOSTATISTICS AND INFORMATICS SHARED RESOURCE (BISR): ABSTRACT The Biostatistics and Informatics Shared Resource (BISR) plays an essential role in the research activities of The University of Kansas Cancer Center (KUCC) by supporting the data science needs of KUCC investigators. The BISR is co-led by Byron Gajewski (CPC), PhD, and Devin Koestler (CB), PhD, both accomplished biostatisticians with a long-standing commitment to cross-disciplinary collaborations. The BISR includes 19 faculty members with specialized cancer biostatistics research expertise, 13 technical support staff and postdoctoral fellows, and three administrative staff members who provide additional technical and administrative expertise, adding efficiency to the resource. The BISR assists KUCC investigators by providing guidance and direction in study design, statistical oversight and analyses, clinical research informatics and data management, electronic data collection, bioinformatics, complex data set (statistical ‘omics) analysis, and investigator-initiated clinical trials. The BISR consists of faculty and staff whose diverse expertise and skill sets span the areas of biostatistics, bioinformatics, and informatics. The considerable overlap between these three areas allows researchers to work with a single shared resource for their data collection, analytics, and statistical analysis needs. The synergy between the areas that encompass “data science” enables the BISR to support a wide range of quality services in a timely and cost-effective manner. To support the research activities of KUCC members, the specific aims of this resource are to: 1) provide study design and statistical support and expertise; 2) provide bioinformatics and statistical genetics support and expertise; 3) provide informatics expertise for data collection and management, as well as develop and support ongoing research enabling technologies, platforms, and tools; and 4) educate students, fellows and faculty members of KUCC on data science, reproducible research ideas, and methods used in cancer research. From 2016-2020, the BISR supported 69, 60, 85, 80, and 78 KUCC members respectively. In 2020, the breakdown was 18, 33, and 27 members from Cancer Biology, Cancer Prevention and Control, and Drug Discovery, Delivery and Experimental Therapeutics, respectively, on 89 grant applications (submissions and resubmissions) and 161 projects (ongoing grants, IITs, and other projects). In addition, the BISR supported 31 non-member cancer researchers in 2020. For all cancer-related projects, the BISR supported 340 grant applications plus projects in 2020. In 2021, CCSG funding accounts for ~10% of the BISR budget, with an annual direct support return on investment of approximately $0.6M dollars in external funding to support BISR faculty and staff (31% of BISR support).

生物统计学和信息学共享资源（BISR）：摘要 生物统计学和信息学共享资源（BISR）在研究活动中起着至关重要的作用 堪萨斯大学癌症中心（KUCC）通过支持KUCC研究人员的数据科学需求。 BISR由Byron Gajewski（CPC），PhD和Devin Koestler（CB）共同领导，PhD都完成了 生物统计学家对跨学科合作的长期承诺。 BISR包括19 具有专业癌症生物统计学研究专业知识，13名技术支持人员和的教职员工 博士后研究员和三名提供额外技术和的行政人员 行政专业知识，提高了资源的效率。 BISR通过提供KUCC调查人员 研究设计，统计监督和分析，临床研究信息的指导和指导 数据管理，电子数据收集，生物信息学，复杂数据集（统计“ OMICS）分析和 研究者发射的临床试验。 BISR由教职员工组成，他们的潜水员专业知识和技能涵盖了生物统计学领域， 生物信息学和信息。这三个领域之间的相当重叠使研究人员能够 使用单个共享资源来收集数据，分析和统计分析需求。这 包含“数据科学”的领域之间的协同作用使BISR能够支持广泛的质量 及时且具有成本效益的方式。为了支持KUCC成员的研究活动， 该资源的具体目的是：1）提供研究设计，统计支持和专业知识； 2）提供 生物信息学和统计遗传学支持和专业知识； 3）为数据收集提供信息专业知识 以及管理以及开发和支持正在进行的研究促进技术，平台和 工具; 4）教育数据科学KUCC的学生，研究员和教职员工，可再现研究 癌症研究中使用的思想和方法。从2016 - 2020年开始，BISR支持69、60、85、80和78 KUCC成员分别。在2020年，癌症生物学的分解为18、33和27名成员， 癌症预防和控制以及药物发现，递送和实验治疗剂 89个赠款申请（提交和重新提交）和161个项目（持续的赠款，IIT和其他 项目）。此外，BISR在2020年支持31名非会员癌症研究人员。 项目，BISR支持340个赠款申请加上2020年的项目。2021年，CCSG资助帐户 〜BISR预算的10％，年度直接支持投资回报率约为60万美元 外部资金以支持BISR教职员工（BISR支持的31％）。