Task Order One (1) shall encompass conduct of and support for student training and education activities, support for educational and training activities, and preparation of manuscripts.

任务令一 (1) 应包括开展和支持学生培训和教育活动、支持教育和培训活动以及准备稿件。

• 批准号: 10683915
• 负责人: WENDY WHITE
• 金额: $ 121.46万
• 依托单位: TOUGALOO COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-13 至 2023-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683915
• 关键词: Abdomen; African American; African American population; Age; Aorta; Area; Atherosclerosis Risk in Communities; Back; Behavioral Genetics; Biochemical; Biological; Biological Assay; Biomedical Research; Candidate Disease Gene; Cardiovascular Diseases; Cardiovascular system; Clinical; Communities; Community Health Education; County; Cryopreservation; DNA; Data; Data Collection; Data Set; Disease; Echocardiography; Education and Outreach; Educational Activities; Educational Status; Enrollment; Environmental Risk Factor; Event; Family; Family Sizes; Future; Genetic Risk; Genome Scan; Hospitalization; Injury; Investigation; Jackson Heart Study; Knowledge; Lymphocyte; Manuscripts; Mathematics; Measures; Mentorship; Participant; Preparation; Psychosocial Factor; Publications; Research; Resources; Risk Factors; Sampling; Science; Scientist; Students; Training; Training Activity; Training Programs; Training and Education; Underrepresented Minority; Validation; Vital Status; X-Ray Computed Tomography; aged; base; biomedical profession; cardiac magnetic resonance imaging; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; career; cohort; college; community living; disorder risk; epidemiology study; follow-up; graduate student; healthy lifestyle; heart imaging; high school; innovation; interest; member; metropolitan; minority undergraduate; novel; programs; recruit; residence; social culture; socioeconomics; student training; undergraduate student; underrepresented minority student

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.

杰克逊心脏研究 (JHS) 于 1998 年启动，是一项针对非裔美国人心血管疾病 (CVD) 负担过高的遗传和环境风险因素的纵向调查。 此外，JHS 还开展各种社区教育和外展活动，以促进健康的生活方式并减少疾病风险负担。 它还开展大学本科和研究生水平的培训计划以及高中科学和数学强化计划，以准备和鼓励代表性不足的少数族裔学生从事生物医学职业。 （www.jacksonheartstudy.org/）。 JHS 代表了杰克逊社区动脉粥样硬化风险研究中心 (ARIC) 的扩展 (www2.cscc.unc.edu/aric/)，旨在扩大非裔美国人群体的数据收集，并增加非裔美国人群体和科学家在生物医学研究和专业领域的接触和参与。 该研究招募了 5306 名非裔美国居民，其中 3,732 名居民也参加了 ARIC，居住在密西西比州杰克逊、海因兹县、麦迪逊县和兰金县大都市区。 注册的 JHS 参与者最初年龄为 20 - 90 岁，接受了三项连续考试（考试 1，2000-04；考试 2，2005-08；考试 3，2009-13），并且每年都会联系。截至 2016 年底，超过 345 种出版物发表了关于身体、行为、遗传和心理社会因素的丰富数据的研究结果。 参与者考试产生了有关传统和假定的 CVD 风险因素、社会经济和社会文化因素以及生化分析物的广泛纵向数据；以及通过心脏、主动脉和腹部的超声心动图、心脏磁共振成像 (MRI) 和计算机断层扫描 (CT) 扫描来测量亚临床疾病。储存的生物样本已进行了假定的生化风险因素的分析，并储存以供将来的研究使用。提取 DNA 并冷冻保存淋巴细胞，用于候选基因研究、全基因组扫描、表达和其他组学研究。 该研究包括 428 个家庭的嵌套组成部分，基线时平均家庭规模为 5 人；如今，仍有 331 个至少有 1 名在世成员的家庭积极参与。 幸存队列的参与率很高：两次随访检查的参与率分别为 80% (N=4205) 和 72% (N=3820)。如今，同龄人的平均年龄为 68 岁。自基线以来，每 12 个月就会联系一次队列成员，以获取有关生命状况、当前居住地、重大疾病或伤害以及接触者之间发生的住院情况的信息，以确定感兴趣的临床 CVD 事件。由于 JHS 与 ARIC 共享队列成员资格，这两项研究在事件验证方面相互合作。