Improving Adherence to Breast Cancer Treatment Guidelines in Nigeria

提高尼日利亚对乳腺癌治疗指南的遵守率

基本信息

  • 批准号:
    10684652
  • 负责人:
  • 金额:
    $ 19.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-30 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Background: Breast cancer is the most common cause of cancer incidence and mortality in women in Nigeria. Survival is poor, in part due to inadequate access to effective treatment. The National Comprehensive Cancer Network (NCCN) Harmonized Guidelines for sub-Saharan Africa (SSA) were developed to promote delivery of evidence-based, context-appropriate breast cancer care. Dr. Romanoff’s prior work shows that receiving multi- disciplinary, guideline-concordant breast cancer care in Nigeria is associated with improved outcomes. Nonetheless, guideline implementation and adherence are sporadic and have not been systematically evaluated. The overall goal of this K08 proposal is to facilitate Dr. Romanoff’s development into an independent investigator in global oncology, focusing on strategies to enhance evidence-based breast cancer care delivery in resource- limited settings. This research aims to develop and evaluate strategies to improve healthcare provider adherence to clinical practice guidelines for breast cancer care in Nigeria. Candidate: Dr. Romanoff is a Breast Surgical Oncologist at the Icahn School of Medicine at Mount Sinai, where she is an Assistant Professor in the Department of Global Health and Health System Design, as well as a Global Cancer Disparities Researcher at Memorial Sloan Kettering Cancer Center (MSK). Aims for candidate development include education and training in: 1) fundamentals of health services research, 2) implementation science, and 3) global breast oncology. With the candidate development and research activities proposed, Dr. Romanoff will develop the tools necessary to become an independent investigator and leader in the field of global oncology, and meet her ultimate goal of improving breast cancer outcomes in resource-limited settings worldwide. Research: This research will use rigorous implementation science frameworks and methodologies to accelerate adherence to the NCCN Harmonized Guidelines for SSA in Nigeria, with the ultimate goal of reducing the evidence-to-practice gap and improving evidence-based breast cancer treatment. To achieve this, Dr. Romanoff will leverage the research infrastructure of the African Research Group for Oncology (ARGO), a research consortium including MSK and 26 Nigerian academic institutions. The overall hypothesis is that implementation of structured, multi-level strategies to enhance adherence to breast cancer care guidelines in Nigeria will be acceptable, appropriate, feasible and adoptable – and show promise to change clinical practice. Study aims are to: 1) identify multi-level barriers to guideline-concordant breast cancer care in Nigeria, 2) develop evidence-based implementation strategies to improve adherence to breast cancer clinical practice guidelines in Nigeria, and 3) rigorously evaluate selected implementation strategies in a pilot study in Nigeria. The rationale that underlies this proposal is that implementation of context-appropriate strategies to promote guideline adherence will improve breast cancer care delivery in Nigeria, and ultimately patient survival.
项目摘要/摘要 背景:乳腺癌是尼日利亚妇女癌症发病率和死亡率最常见的原因。 存活率很低,部分原因是无法获得有效治疗。美国国家综合癌症 为撒哈拉以南非洲制定了协调准则,以促进 以证据为基础的、与环境相适应的乳腺癌护理。罗曼诺夫博士先前的工作表明,接受多- 在尼日利亚,规范的、符合指南的乳腺癌治疗与改善的结果相关。 尽管如此,指导方针的执行和遵守是零星的,并没有得到系统的评价。 本K 08提案的总体目标是促进罗曼诺夫博士发展成为一名独立的研究者 在全球肿瘤学,重点是战略,以加强以证据为基础的乳腺癌护理提供资源, 有限的设置。本研究旨在制定和评估策略,以提高医疗服务提供者的依从性 尼日利亚乳腺癌护理临床实践指南。候选人:罗曼诺夫医生是一名乳房外科医生 西奈山伊坎医学院的肿瘤学家,她是该部门的助理教授 全球健康和健康系统设计的负责人,以及纪念医院的全球癌症差异研究员 斯隆凯特琳癌症中心(MSK)。候选人发展的目标包括以下方面的教育和培训:1) 卫生服务研究基础,2)实施科学,3)全球乳腺肿瘤学。与 候选人的发展和研究活动提出,罗曼诺夫博士将开发必要的工具, 成为全球肿瘤学领域的独立研究者和领导者,并实现她的最终目标, 在全球资源有限的环境中改善乳腺癌的预后。研究:本研究将使用 严格的实施科学框架和方法,以加速遵守NCCN 尼日利亚卫生服务协调准则,最终目标是缩小证据与实践之间的差距, 改善基于证据的乳腺癌治疗。为了实现这一目标,罗曼诺夫博士将利用研究 非洲肿瘤学研究小组(ARGO)的基础设施,这是一个包括MSK和 尼日利亚26所大学总体假设是,实施结构化、多层次的 在尼日利亚,加强遵守乳腺癌护理指南的策略是可以接受的,适当的, 可行的和可采用的-并显示出改变临床实践的希望。研究的目的是:1)识别多层次 尼日利亚指南一致性乳腺癌治疗的障碍,2)制定循证实施方案 提高尼日利亚乳腺癌临床实践指南依从性的策略,以及3)严格 在尼日利亚的一项试点研究中评价选定的执行战略。这一建议的基本原理是 实施与环境相适应的策略来促进指南的遵守将改善乳房 在尼日利亚的癌症治疗,并最终提高患者的生存率。

项目成果

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Anya Romanoff其他文献

Anya Romanoff的其他文献

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{{ truncateString('Anya Romanoff', 18)}}的其他基金

Improving Adherence to Breast Cancer Treatment Guidelines in Nigeria
提高尼日利亚对乳腺癌治疗指南的遵守率
  • 批准号:
    10351812
  • 财政年份:
    2022
  • 资助金额:
    $ 19.64万
  • 项目类别:

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