Childhood Maltreatment and Disease Risk in Young Adulthood: The Role of HPA Regulation in Adolescence
童年虐待和青年期疾病风险:HPA 调节在青春期的作用
基本信息
- 批准号:10684099
- 负责人:
- 金额:$ 66.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescenceAdolescent DevelopmentAdultBiologicalBiological AgingBiological MarkersBody mass indexC-reactive proteinCalibrationCardiovascular DiseasesCaregiversCellsChildChild AbuseChild Abuse and NeglectChildhoodChronicChronic DiseaseClinicalCommunitiesDataData SetDevelopmentDiseaseEarly-life traumaEconomic BurdenEnrollmentEpigenetic ProcessEthnic OriginFunctional disorderFutureHealthImmuneIndividualIndividual DifferencesInflammatoryInterleukin-6InterventionKnowledgeLifeLinkLongitudinal StudiesLung diseasesMalignant NeoplasmsMeasuresMediationMental HealthMetabolic syndromeModelingMorbidity - disease rateOutcomePathway interactionsPatternPhysiologicalPreventionProcessRecording of previous eventsRegulationReportingRiskRisk FactorsRoleSelf PerceptionSeveritiesShapesSocial supportStressSymptomsSystemTNF geneTechniquesTestingTimeTraumaVulnerable PopulationsWell in selfWorkYouthallostatic loadbiological adaptation to stresschild neglectcomparison groupcostdisorder riskearly life stressexperiencefollow up assessmenthypothalamic-pituitary-adrenal axisimprovedindexinginnovationinsightlongitudinal datasetmaltreatmentmortalityphysical conditioningpreventprospectiveprotective factorsracial minorityresilienceresponsesocialtransmission processyoung adult
项目摘要
Abstract
Child maltreatment is a significant and costly social issue with over 670,000 documented cases annually. The
effects of maltreatment are wide-ranging and include increased rates of morbidity and mortality from chronic
diseases. To improve the health and mortality of this vulnerable population it is critical to delineate the
pathways through which maltreatment contributes to increased risk for disease and identify opportunities for
prevention. Dysregulation of the body’s physiological stress response systems constitutes a key pathway
through which early maltreatment shapes biological aging processes and risk for subsequent disease. In
addition, recalibration of the stress system during adolescence may mitigate the effects of early trauma on
disease risk. Although the HPA axis in particular has been implicated as a key mechanism linking maltreatment
with disease, these associations have only been tested between any two of these variables (i.e., maltreatment
and HPA axis function, maltreatment and disease, or HPA axis function and disease) using cross-sectional or
retrospective reports of maltreatment. This study will be the first to test this hypothesized mediation model from
maltreatment to disease risk via HPA functioning using a developmental framework from childhood to young
adulthood, incorporating multiple indices of disease risk. Second, the proposed work will be the first to use
innovative new modeling techniques to characterize HPA axis functioning across four timepoints in
adolescence to pinpoint the particular aspects of the stress response and developmental periods of stress
system sensitivity that may lead to disease risk. Finally, this study will move beyond current conceptualizations
of stress system dysfunction by identifying resilient profiles of HPA axis functioning and moderators of HPA
axis recalibration that will provide critical new insights for intervention efforts focused on mitigating the effects
of maltreatment on disease risk. The importance of assessing disease risk in young adulthood is bolstered by
data indicating this period of life as a potential inflection point for long-term disease risk. As such, young
adulthood may be a critical window for prevention and an optimal time to assess modifiable health risks. To
accomplish this, we will leverage a unique prospective longitudinal dataset including youth with documented
maltreatment histories and a comparison group from the same communities (90% minority race/ethnicity). This
exemplary dataset will be augmented with follow-up assessment in young adulthood to capture disease risk.
The findings will provide the first longitudinal evidence of HPA axis as a critical mechanism through which
childhood maltreatment contributes to a lifelong trajectory of disease and whether recalibration of the HPA axis
in adolescence can mitigate the effects of early trauma on disease risk in young adulthood. Identification of
specific moderators of HPA axis recalibration can directly inform intervention and prevent stress-induced
disease.
摘要
虐待儿童是一个重大且代价高昂的社会问题,每年有超过67万起有记录的案件。这个
虐待的影响是广泛的,包括增加慢性疾病的发病率和死亡率。
疾病。为了改善这一弱势群体的健康和死亡率,至关重要的是要划定
虐待导致疾病风险增加的途径,并确定
预防。人体生理应激反应系统的失调构成了一条关键途径
通过早期虐待形成生物衰老过程和后续疾病的风险。在……里面
此外,青春期应激系统的重新校准可能会减轻早期创伤对
疾病风险。尽管HPA轴被认为是联系虐待的关键机制
对于疾病,这些关联只在这些变量中的任何两个之间进行了测试(即虐待
和HPA轴功能、虐待和疾病,或HPA轴功能和疾病)使用横断面或
关于虐待的回顾报告。这项研究将是第一次测试这一假设的调解模型
利用从儿童到青年的发展框架,通过HPA功能来虐待疾病风险
成年期,包括疾病风险的多个指数。其次,拟议中的工作将是第一个使用
创新的新建模技术,以表征HPA轴在四个时间点上的功能
青春期确定应激反应的特定方面和应激的发展阶段
可能导致疾病风险的系统敏感性。最后,这项研究将超越目前的概念化
通过确定HPA轴功能的弹性分布和HPA的调节因子来评估应激系统功能障碍
AXIS重新校准,这将为侧重于减轻影响的干预工作提供关键的新见解
关于疾病风险的虐待。在青年时期评估疾病风险的重要性得到了以下支持
数据表明,这一生命阶段是长期疾病风险的潜在拐点。因此,年轻的
成年期可能是预防的关键窗口,也是评估可改变的健康风险的最佳时机。至
要做到这一点,我们将利用一个独特的前瞻性纵向数据集,其中包括有记录的青年
虐待史和来自相同社区的对照组(90%的少数族裔/族裔)。这
示范数据集将通过青年时期的后续评估来扩大,以捕捉疾病风险。
这些发现将提供HPA轴作为关键机制的第一个纵向证据
童年虐待有助于疾病的终生轨迹,以及HPA轴的重新校准
在青春期可以减轻早期创伤对青春期疾病风险的影响。身份识别
HPA轴重新校准的特定调节剂可以直接为干预提供信息,防止应激诱导
疾病。
项目成果
期刊论文数量(0)
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Sonya L Negriff其他文献
Sonya L Negriff的其他文献
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{{ truncateString('Sonya L Negriff', 18)}}的其他基金
Childhood Maltreatment and Disease Risk in Young Adulthood: The Role of HPA Regulation in Adolescence
童年虐待和青年期疾病风险:HPA 调节在青春期的作用
- 批准号:
10446121 - 财政年份:2022
- 资助金额:
$ 66.97万 - 项目类别:
Linking DNA methylation with child maltreatment and mental health across adolescence
将 DNA 甲基化与儿童虐待和整个青春期的心理健康联系起来
- 批准号:
10349509 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Linking DNA methylation with child maltreatment and mental health across adolescence
将 DNA 甲基化与儿童虐待和整个青春期的心理健康联系起来
- 批准号:
10558621 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Online Social Networks and Risky Sexual Behavior in Maltreated Adolescents
在线社交网络和受虐待青少年的危险性行为
- 批准号:
8826795 - 财政年份:2012
- 资助金额:
$ 66.97万 - 项目类别:
Online Social Networks and Risky Sexual Behavior in Maltreated Adolescents
在线社交网络和受虐待青少年的危险性行为
- 批准号:
9025805 - 财政年份:2012
- 资助金额:
$ 66.97万 - 项目类别:
Online Social Networks and Risky Sexual Behavior in Maltreated Adolescents
在线社交网络和受虐待青少年的危险性行为
- 批准号:
8651931 - 财政年份:2012
- 资助金额:
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Online Social Networks and Risky Sexual Behavior in Maltreated Adolescents
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Online Social Networks and Risky Sexual Behavior in Maltreated Adolescents
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8299920 - 财政年份:2012
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