Developmental Research Program

项目摘要 这个P20应用的发展研究计划(DRP)的主要目标是促进癌症的发展 卡马诺斯癌症研究所(KCI)的健康差距研究任务，开发创新研究 具有科学合理性和可译性的项目。DRP提供了一个独特的机会来征求新的 研究思路和鼓励开发高转化率的癌症健康差异项目 潜力。这些项目为研究人员提供了进行高影响力翻译研究的资源 与我们P20孢子的目标一致。这些目标将通过以下具体目标实现：1) 利用现有的行政部门，通过高度结构化的流程征求DRP建议书 KCI的结构；2)由DRP审查委员会审查新项目和更新项目的申请，该委员会 将向执行委员会建议最多两项新申请和两项续期申请 (第一年除外，将支持两个新项目)；3)监测和评价资助的项目 进展和翻译潜力，并评估他们成为完整的P50“孢子准备”翻译的潜力 项目；以及4)将DRP调查员纳入孢子社区，要求每月参加 会议和小组交流，并为扩大合作提供机会。我们将利用 KCI用于DRP的现有基础设施，以满足P20孢子和杠杆的翻译目标 已经建立了征集申请的机制。这些机制还有助于培养优秀的 研究癌症健康差异的科学，招聘新教员到重点领域，指导初级教员，并鼓励 研究合作。新的和更新的DRP项目的PIE将需要提交书面摘要 10个月后向DRP委员会提交研究成果，并在每月一次的 由孢子项目的共同领导人和核心主任组成的执行委员会会议。 这次会议将被用来确定DRP项目是否足够值得考虑 作为内部咨询委员会的全面翻译项目，紧随其后的是EAB和P20癌症行动 委员会，作为未来底特律癌症健康差异P50孢子应用的一部分。这一计划将 鼓励KCI和韦恩州立大学的广泛调查人员参与，提供 支持有潜力发展为有影响力的翻译项目的试点项目。它还鼓励人们 并促进新的研究方向、方法和合作的发展。重要的是，KCI 已承诺每年提供所需资金，以资助民研计划每年最多资助两个新项目 每个项目每年最多50,000美元(每年最多可续签两个项目 2和3)。

Project Summary The primary goal of the Developmental Research Program (DRP) of this P20 application is to advance the cancer health disparities research mission at the Karmanos Cancer Institute (KCI) by developing innovative research projects that are scientifically sound and translatable. The DRP provides a unique opportunity for soliciting new research ideas and encourages development of cancer health disparities projects with high translational potential. These projects provide investigators with the resources to conduct high-impact translational research consistent with our P20 SPORE's objectives. The goals will be achieved through the following specific aims: 1) Solicitation of DRP proposals through a highly structured process by leveraging the existing administrative structure of the KCI; 2) Review applications for new and renewal projects by a DRP Review Committee, which will recommend up to two new applications and two renewal applications for funding to the Executive Committee (except for the first year, where two new projects will be supported); 3) Monitor and evaluate funded projects for progress and translational potential, and assess their potential to become full P50 “SPORE-ready” translational projects; and 4) Integrate DRP investigators into the SPORE community by requiring participation in monthly meetings and group communications, and by providing opportunities for expanded collaborations. We will utilize KCI's existing infrastructure for the DRP to meet the translational objectives of the P20 SPORE and leverage already established mechanisms to solicit applications. These mechanisms also serve to foster excellent science in cancer health disparities, recruit new faculty to areas of focus, mentor junior faculty, and encourage research collaborations. PIs of new and renewal DRP projects will be required to submit written summaries of research accomplishments to the DRP Committee after 10 months and present these at one of the monthly meetings of the Executive Committee comprised of the co-leaders of the SPORE projects and core directors. This meeting will be used to determine whether the DRP projects are sufficiently meritorious for consideration as full translational projects by the Internal Advisory Board, followed by the EAB and the P20 Cancer Action Council, as part of a future Detroit Cancer Health Disparities P50 SPORE application. This program will encourage participation from a broad range of investigators at KCI and Wayne State University by providing support for pilot projects with the potential to develop into impactful translational projects. It also encourages and facilitates the development of new research directions, methodologies, and collaborations. Importantly, KCI has committed to provide the required funds annually for the DRP to fund up to two new projects every year at a maximum of $50,000 per project per year (with the potential of renewal for up to two projects per year in years 2 and 3).