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Genomics Bioinformatics

基因组学生物信息学

基本信息

批准号：
10683969
负责人：
Christopher W Benner
金额：
$ 24.87万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683969
关键词：
ATAC-seq Atherosclerosis Bioinformatics Biological Assay Cardiovascular system Cells ChIP-seq Chromatin Collection Computer software Core Facility DNA Data Development Disease Gene Expression Gene Expression Profiling Genetic Genetic Transcription Genome Mappings Genomics Glass Infrastructure Laboratories Libraries Macrophage Massive Parallel Sequencing Measures Methodology Methods Pathologic Preparation Procedures Proteins Protocols documentation Public Domains Publishing RNA Resources Scientist Secure Services Software Tools Standardization Tissues Visualization Work base cell type computer infrastructure computerized data processing computerized tools computing resources deep sequencing dietary experimental study genomic locus nonalcoholic steatohepatitis pharmacologic programs reference genome single-cell RNA sequencing skills supercomputer transcription factor transcriptome sequencing

项目摘要

PROJECT SUMMARY Core B. Genomics Bioinformatics A Genomics and Bioinformatics Core is proposed to enable the application of massively parallel sequencing- based approaches to advance the understanding of pathological programs of gene expression that contribute to the development of atherosclerosis and NASH. An essential aspect of all four Projects of this PPG will be to define the consequences of genetic, dietary and pharmacologic perturbations on global programs of gene expression in relevant tissues and cell types. The PPG Genomics and Bioinformatics Core will provide two complementary services to advance these efforts; 1) technical support and resources for preparation and sequencing of libraries enabling bulk RNA-Seq, single cell RNA-Seq, ATAC-Seq and ChIP-Seq assays and 2) corresponding bioinformatics and computational support to allow effective analysis of the resulting data.

项目摘要核心B。基因组学生物信息学提出了一个基因组学和生物信息学核心，以实现大规模并行测序的应用- 的方法，以促进对基因表达的病理程序的理解，动脉粥样硬化和NASH的发展。本PPG所有四个项目的一个重要方面是定义遗传、饮食和药理学干扰对全球基因工程的影响在相关组织和细胞类型中表达。PPG基因组学和生物信息学核心将提供两个提供补充服务，以推动这些努力;（1）提供技术支助和资源，能够进行批量RNA-Seq、单细胞RNA-Seq、ATAC-Seq和ChIP-Seq测定的文库测序，以及2）相应的生物信息学和计算支持，以允许对所得数据进行有效分析。