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Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) Study

女性健康饮食和生活 (WHEL) 研究中的红细胞多不饱和脂肪酸与乳腺癌死亡率

基本信息

批准号：
10684219
负责人：
Humberto Parada
金额：
$ 18.56万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-04 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10684219
关键词：
Affect Angiogenesis Inhibitors Animals Anti-Inflammatory Agents Apoptotic Attention Behavioral Biological Biological Markers Biometry Blood specimen Breast Cancer Cell Breast Cancer Epidemiology Breast Cancer survivor California Cancer Center Cancer Etiology Cancer Prognosis Carcinogenesis Inhibition Caucasians Cessation of life Cohort Studies Confidence Intervals Counseling Development Diagnosis Diet and Nutrition Dietary Factors Dietary Fiber Dietary Intervention Dietary Practices Dietary intake Doctor of Philosophy Enrollment Environment Environmental Health Epidemiologist Epidemiology Erythrocytes Event Fabaceae Fasting Fatty Acids Fatty acid glycerol esters Fiber Fishes Food Fruit Gene Expression Genes Genetic Geographic Locations Goals Guidelines Healthy Eating Incidence Inflammation Intake International K-Series Research Career Programs Knowledge Laboratory Study Linear Regressions Literature Malignant Neoplasms Mammary Neoplasms Measurement Measures Mentors Molecular Epidemiology North Carolina Nutrient Nutritional Science Omega-3 Fatty Acids Omega-6 Fatty Acids Outcome Patient Self-Report Plants Plasma Polyunsaturated Fatty Acids Prognosis Quality of life Randomized Recommendation Research Research Personnel Resources Risk Reduction Role Sampling Seasons Site Source Structural Models Time Training United States Universities Variant Vegetables Whole Blood Woman analytical method angiogenesis anticancer research breast cancer progression cancer diagnosis carcinogenesis career development cohort comparison group design diet and cancer dietary dietary guidelines epidemiology study fruits and vegetables gene interaction hazard improved mRNA Expression malignant breast neoplasm member mortality nano-string novel nutrition related cancer primary care clinician professor randomized trial saturated fat skill acquisition skills tenure track therapy design

项目摘要

Project Summary Humberto Parada Jr, PhD, is tenure-track Assistant Professor of Epidemiology at San Diego State University (SDSU) and Associate Member of the University of California, San Diego (UCSD) Moores Cancer Center. Dr. Parada received his Ph.D. in epidemiology from the University of North Carolina at Chapel Hill (UNC) in 2016. As a cancer epidemiologist, Dr. Parada’s research goals are to identify environmental, behavioral (including dietary), and genetic factors that influence the development and progression of breast cancer, the most frequently diagnosed cancer and the second leading cause of cancer-related death among women in the United States (US), in order to refine risk reduction strategies to reduce the burden of breast cancer nationally and internationally. His proposal entitled “Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women’s Healthy Eating and Living (WHEL) Study” seeks to investigate, using structural models, the associations between four ω-3 and four ω-6 polyunsaturated fatty acids measured in red blood cells (RBC) and mortality following breast cancer and gene expression in breast tumor samples. To date, the few epidemiologic studies that have examined fatty acids and breast cancer mortality have relied on self- reported assessments, which are subject to measurement error. The use of a biomarker measure together with novel analytical methods will allow Dr. Parada to objectively and more accurately estimate the associations between these eight polyunsaturated fatty acids and breast cancer mortality. Furthermore, while laboratory studies using breast cancer cells and animal studies have identified important mechanisms by which fatty acids may impact carcinogenesis and progression, no studies have examined fatty acids relative to gene expression in breast tumor samples. Documenting the associations between RBC fatty acids and breast cancer mortality would help to inform dietary intake guidelines among women diagnosed with breast cancer. The proposed career development and training plan includes three training goals to enhance Dr. Parada’s trajectory toward becoming an independent investigator: 1) Obtain training in nutrition science and nutrition-related cancer research, 2) Develop expertise in technical, analytic and conceptual approaches for biomarkers, and 3) Improve skills in grantsmanship and participate in career development opportunities. This project will be carried out at SDSU and UCSD under the guidance of his mentoring team with expertise in breast cancer epidemiology (Primary mentor: M. Elena Martinez, PhD), diet/nutrition (Co-mentor: Cheryl L. Rock, PhD, RD), environmental health (Co-mentor: Eunha Hoh, PhD), molecular epidemiology (Co-mentor: Melissa A. Troester, PhD), and biostatistics (Collaborator: Mingan Yang, PhD).

项目摘要 Humberto Parada Jr博士是圣地亚哥州立大学流行病学终身助理教授大学（SDSU）和加州大学圣地亚哥分校（UCSD）的准会员中心Parada博士获得了博士学位。来自北卡罗来纳州查佩尔山大学的流行病学专家 (UNC)2016年作为一名癌症流行病学家，帕拉达博士的研究目标是确定环境，行为（包括饮食）和遗传因素，影响乳腺癌的发展和进展癌症是最常见的癌症，也是癌症相关死亡的第二大原因。美国（US）的女性，以完善降低风险的策略，以减轻乳腺癌的负担癌症在国内和国际上他的提案题为“红细胞多不饱和脂肪酸和女性健康饮食和生活（WHEL）研究中的乳腺癌死亡率”旨在调查，使用结构模型，四种ω-3和四种ω-6多不饱和脂肪酸之间的关联，以红色表示血细胞（RBC）和乳腺癌后的死亡率以及乳腺肿瘤样品中的基因表达。到目前为止，少数几项研究脂肪酸和乳腺癌死亡率的流行病学研究依赖于自我- 报告的评估，这是受测量误差。使用生物标志物测量与新的分析方法将使帕拉达博士能够客观、更准确地估计这八种多不饱和脂肪酸和乳腺癌死亡率之间的关系。虽然实验室使用乳腺癌细胞的研究和动物研究已经确定了脂肪酸可能影响癌的发生和发展，没有研究检查脂肪酸与基因表达的关系在乳腺肿瘤样本中。记录RBC脂肪酸与乳腺癌死亡率之间的关联将有助于为诊断为乳腺癌的妇女提供膳食摄入指南。建议的职业发展及培训计划包括三个培训目标，以提升陈博士的专业水平。 Parada成为独立研究者的轨迹：1）获得营养科学方面的培训，与营养有关的癌症研究，2）发展技术，分析和概念方法的专业知识，生物标志物，以及3）提高granitarian技能，并参与职业发展机会。这该项目将在SDSU和UCSD的指导下进行，他的指导团队具有以下方面的专业知识乳腺癌流行病学（主要导师：M。Elena Martinez博士），饮食/营养（共同导师：Cheryl L. Rock，PhD，RD）、环境健康（共同导师：Eunha Hoh，PhD）、分子流行病学（共同导师： Melissa A. Troester，PhD）和生物统计学（合作者：Mingan Yang，PhD）。