Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

项目总结/摘要 杏仁核基底外侧复合体（BLA）的直接电刺激（DES）可以改善 陈述性记忆，反映了BLA在调节内侧颞叶记忆过程中的作用 (MTL)区域作为情绪唤起的功能。因此，DES可以揭示BLA介导的记忆机制 与人类心理健康和疾病相关的增强。BLA的DES可用于询问 记忆回路的功能，特别是MTL中的神经元振荡如何支持陈述性记忆。第一、 假设BLA能够优先考虑最初遇到的信息的长期保留 时间上相邻的。第二，BLA优先投射到MTL前部区域，因此假设BLA 优先调节这些解剖区域的记忆过程，这些过程被认为支持记忆， 非空间项目比空间位置记忆更重要。第三，虽然情绪激动，杏仁核 活动，MTL活动和内存性能通常是相关的，我们假设DES将揭示， BLA输出到其他MTL区域，通过直接引发前记忆， 这些网络中的振荡状态。预期成果代表着基本人权的重大进展， 科学的正常记忆功能和重大运动的新疗法，旨在模拟 记忆增强的内源性机制。

PROJECT SUMMARY/ABSTRACT Direct electrical stimulation (DES) of the basolateral complex of the amygdala (BLA) can improve declarative memory, reflecting the role of the BLA in modulating memory processes in medial temporal lobe (MTL) regions as a function of emotional arousal. Thus, DES can reveal mechanisms of BLA-mediated memory enhancement relevant to human mental health and disease. DES of the BLA can be used to interrogate the function of memory circuits, especially how neuronal oscillations in the MTL support declarative memory. First, BLA is hypothesized to wield the capacity to prioritize long-term retention of information initially encountered adjacent in time. Second, the BLA preferentially projects to anterior MTL regions and thus is hypothesized to preferentially modulate memory processes in those anatomic regions, processes thought to support memory for non-spatial items more so than memory for spatial locations. Third, although emotional arousal, amygdala activity, MTL activity, and memory performance are typically correlated, we hypothesize that DES will reveal that BLA outputs to other MTL regions cause improved memory performance by directly eliciting pro-memory oscillatory states in those networks. The expected outcomes represent a significant advancement for the basic science of normal memory function and significant movement towards novel therapeutics designed to emulate endogenous mechanisms of memory enhancement.