Center Core Grant for Vision Research

视觉研究中心核心资助

• 批准号: 10700841
• 负责人: Yutao Liu
• 金额: $ 57.35万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700841
• 关键词: Allied Health Sciences; Award; Basic Science; Blindness; Center Core Grants; Clinical; Collaborations; Communication; Core Grant; Dentistry; Development; Discipline of Nursing; Disease; Doctor of Philosophy; Ensure; Equipment; Financial Support; Funding; Gene Expression; Goals; Grant; Group Meetings; Health Sciences; Healthcare; Histology; Human Resources; Image; Infrastructure; Institution; Investigational Therapies; Laboratories; Methodology; Mission; Names; Ophthalmologist; Patients; Pilot Projects; Productivity; Proteomics; Research; Research Personnel; Research Project Grants; Research Support; Resources; Schools; Scientist; Series; Services; Talents; Technology; Time; Travel; Universities; Vision; Vision Disorders; Vision research; Visual System; clinically relevant; cohort; college; instrumentation; investigator training; medical schools; programs; recruit; research faculty; success; undergraduate student; vision science

Overall: Project Summary The vision science group at Augusta University/Medical College of Georgia is known collectively as the James and Jean Culver Vision Discovery Institute (Culver VDI). The mission of the Culver VDI is to engage in high impact research and discovery for patients suffering from blindness and visual disorders. Within this group of basic science researchers and ophthalmologists are 22 investigators who direct 15 NEI R01s, 2 NEI R21s and 1 NEI K99. The objective of the center core grant for vision research is (1) to provide crucially needed expertise and instrumentation to enhance the research programs of these talented investigators and (2) to promote collaborations within the group and with scientists across the nation. To achieve this mission, we have organized facilities, services and shared instrumentation into the following three modules: (1) Visual Function Assessment; (2) Histology and Imaging; (3) Gene Expression/Proteomics. These modules provide research resources, services and shared instrumentation that are essential to the success of ongoing projects in multiple laboratories. Support of these modules will boost development of new projects and enhance collaborations bringing the best of the latest technology to our NEI-funded research. Augusta University is committed to vision science and to the Culver VDI, which launched in 2008. Since that time, the University has supported recruitment of 11 vision research faculty with competitive start-up packages and laboratory space across multiple departments and colleges. The University has sponsored clinically-relevant pilot projects and travel awards for trainees, assisted with the purchase of sophisticated instrumentation and facilitated collaboration/communication through the support of a robust seminar series, an annual retreat and monthly group meetings. Support is requested in the form of this Center Core Grant for Vision Research to achieve the following aims: Aim 1. To provide support for module personnel who assist and train investigators and their staff in the use of sophisticated instrumentation and methodology. Aim 2. To provide select services thereby enhancing productivity of Augusta University vision researchers and avoiding unnecessary duplication of equipment/effort. Aim 3. To ensure continued productivity of outstanding clinically-relevant vision research by assisting: a) established and first-time NEI R01-funded investigators, b) established NEI R01-funded investigators who seek to renew their NEI-funded projects or develop new vision-related projects, c) scientists from other fields who bring their scientific expertise to the fields of vision research.

总体：项目总结

项目成果

Clinical and molecular aspects of congenital aniridia - A review of current concepts.

• DOI: 10.4103/ijo.ijo_2255_21
• 发表时间: 2022-07
• 期刊: Indian journal of ophthalmology
• 影响因子: 3.1
• 作者: Tibrewal S;Ratna R;Gour A;Agarkar S;Dubey S;Ganesh S;Kekunnaya R;Sangwan V;Liu Y;Vanita V
• 通讯作者: Vanita V

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

• DOI: 10.1038/s41419-021-03683-y
• 发表时间: 2021-04-09
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Huangfu J;Hao C;Wei Z;Wormstone IM;Yan H;Fan X
• 通讯作者: Fan X

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.

• DOI: 10.1038/s41588-019-0556-y
• 发表时间: 2020-03
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Craig JE;Han X;Qassim A;Hassall M;Cooke Bailey JN;Kinzy TG;Khawaja AP;An J;Marshall H;Gharahkhani P;Igo RP Jr;Graham SL;Healey PR;Ong JS;Zhou T;Siggs O;Law MH;Souzeau E;Ridge B;Hysi PG;Burdon KP;Mills RA;Landers J;Ruddle JB;Agar A;Galanopoulos A;White AJR;Willoughby CE;Andrew NH;Best S;Vincent AL;Goldberg I;Radford-Smith G;Martin NG;Montgomery GW;Vitart V;Hoehn R;Wojciechowski R;Jonas JB;Aung T;Pasquale LR;Cree AJ;Sivaprasad S;Vallabh NA;NEIGHBORHOOD consortium;UK Biobank Eye and Vision Consortium;Viswanathan AC;Pasutto F;Haines JL;Klaver CCW;van Duijn CM;Casson RJ;Foster PJ;Khaw PT;Hammond CJ;Mackey DA;Mitchell P;Lotery AJ;Wiggs JL;Hewitt AW;MacGregor S
• 通讯作者: MacGregor S

RNA-Seq analysis reveals gene expression changes induced by IL-6 trans-signaling activation in retinal endothelial cells.

RNA-Seq 分析揭示了视网膜内皮细胞中 IL-6 反式信号激活诱导的基因表达变化。

• DOI: 10.1016/j.cyto.2020.155375
• 发表时间: 2021-03
• 期刊: Cytokine
• 影响因子: 3.8
• 作者: Robinson R;Brown D;Churchwell L;Lee TJ;Kodeboyina SK;Bloom J;Sharma A;Sharma S
• 通讯作者: Sharma S

Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse.

• DOI: 10.1016/j.exer.2021.108894
• 发表时间: 2022-01
• 期刊: EXPERIMENTAL EYE RESEARCH
• 影响因子: 3.4
• 作者: Xiao, Haiyan;Wang, Jing;Barwick, Shannon R.;Yoon, Yisang;Smith, Sylvia B.
• 通讯作者: Smith, Sylvia B.