Center Core Grant for Vision Research

视觉研究中心核心资助

• 批准号: 10700841
• 负责人: Yutao Liu
• 金额: $ 57.35万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700841
• 关键词: Allied Health Sciences; Award; Basic Science; Blindness; Center Core Grants; Clinical; Collaborations; Communication; Core Grant; Dentistry; Development; Discipline of Nursing; Disease; Doctor of Philosophy; Ensure; Equipment; Financial Support; Funding; Gene Expression; Goals; Grant; Group Meetings; Health Sciences; Healthcare; Histology; Human Resources; Image; Infrastructure; Institution; Investigational Therapies; Laboratories; Methodology; Mission; Names; Ophthalmologist; Patients; Pilot Projects; Productivity; Proteomics; Research; Research Personnel; Research Project Grants; Research Support; Resources; Schools; Scientist; Series; Services; Talents; Technology; Time; Travel; Universities; Vision; Vision Disorders; Vision research; Visual System; clinically relevant; cohort; college; instrumentation; investigator training; medical schools; programs; recruit; research faculty; success; undergraduate student; vision science

Overall: Project Summary The vision science group at Augusta University/Medical College of Georgia is known collectively as the James and Jean Culver Vision Discovery Institute (Culver VDI). The mission of the Culver VDI is to engage in high impact research and discovery for patients suffering from blindness and visual disorders. Within this group of basic science researchers and ophthalmologists are 22 investigators who direct 15 NEI R01s, 2 NEI R21s and 1 NEI K99. The objective of the center core grant for vision research is (1) to provide crucially needed expertise and instrumentation to enhance the research programs of these talented investigators and (2) to promote collaborations within the group and with scientists across the nation. To achieve this mission, we have organized facilities, services and shared instrumentation into the following three modules: (1) Visual Function Assessment; (2) Histology and Imaging; (3) Gene Expression/Proteomics. These modules provide research resources, services and shared instrumentation that are essential to the success of ongoing projects in multiple laboratories. Support of these modules will boost development of new projects and enhance collaborations bringing the best of the latest technology to our NEI-funded research. Augusta University is committed to vision science and to the Culver VDI, which launched in 2008. Since that time, the University has supported recruitment of 11 vision research faculty with competitive start-up packages and laboratory space across multiple departments and colleges. The University has sponsored clinically-relevant pilot projects and travel awards for trainees, assisted with the purchase of sophisticated instrumentation and facilitated collaboration/communication through the support of a robust seminar series, an annual retreat and monthly group meetings. Support is requested in the form of this Center Core Grant for Vision Research to achieve the following aims: Aim 1. To provide support for module personnel who assist and train investigators and their staff in the use of sophisticated instrumentation and methodology. Aim 2. To provide select services thereby enhancing productivity of Augusta University vision researchers and avoiding unnecessary duplication of equipment/effort. Aim 3. To ensure continued productivity of outstanding clinically-relevant vision research by assisting: a) established and first-time NEI R01-funded investigators, b) established NEI R01-funded investigators who seek to renew their NEI-funded projects or develop new vision-related projects, c) scientists from other fields who bring their scientific expertise to the fields of vision research.

总体：项目摘要 奥古斯塔大学/格鲁吉亚医学院的视觉科学小组被统称为詹姆斯 Jean Culver Vision Discovery Institute（Culver）卡尔弗探测器的使命是 对失明和视力障碍患者的研究和发现产生影响。该组内 基础科学研究人员和眼科医生是22名研究人员，他们指导15名NEI R 01，2名NEI R21， 1 NEI K99。视觉研究中心核心补助金的目标是（1）提供急需的 专业知识和仪器，以加强这些有才华的研究人员的研究计划和（2）， 促进小组内部以及与全国各地科学家的合作。为了完成这一使命，我们 将设施、服务和共享仪器设备组织成以下三个模块：（1）视觉功能 评估;（2）组织学和成像;（3）基因表达/蛋白质组学。这些模块提供研究 资源，服务和共享工具，这是必不可少的成功正在进行的项目，在多个 laboratories.对这些模块的支持将促进新项目的开发并加强合作 将最先进的技术带到我们NEI资助的研究中。奥古斯塔大学致力于愿景 以及2008年发射的卡尔弗火箭。从那时起，大学一直支持 招聘11名视觉研究教师，提供有竞争力的启动包和实验室空间， 多个部门和学院。该大学赞助了临床相关的试点项目和旅行 为受训人员提供奖励，协助购买先进的仪器， 通过支持一系列强有力的研讨会、年度务虚会和每月一次的 小组会议。支持是要求在这个视觉研究中心核心补助金的形式，以实现 目标：目标1。为协助和培训调查员及其工作人员的模块人员提供支持 工作人员在使用先进的仪器和方法。目标2.从而提供精选服务 提高奥古斯塔大学视觉研究人员的生产力，避免不必要的重复， 设备/努力。目标3.通过以下方式确保出色的临床相关视力研究的持续生产力： 协助：a）已建立和首次获得NEI R 01资助的研究者，B）已建立的NEI R 01资助的研究者 寻求更新NEI资助项目或开发新的视觉相关项目的研究人员，c）科学家 将他们的专业知识带到视觉研究领域。

项目成果

Clinical and molecular aspects of congenital aniridia - A review of current concepts.

• DOI: 10.4103/ijo.ijo_2255_21
• 发表时间: 2022-07
• 期刊: Indian journal of ophthalmology
• 影响因子: 3.1
• 作者: Tibrewal S;Ratna R;Gour A;Agarkar S;Dubey S;Ganesh S;Kekunnaya R;Sangwan V;Liu Y;Vanita V
• 通讯作者: Vanita V

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

• DOI: 10.1038/s41419-021-03683-y
• 发表时间: 2021-04-09
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Huangfu J;Hao C;Wei Z;Wormstone IM;Yan H;Fan X
• 通讯作者: Fan X

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.

• DOI: 10.1038/s41588-019-0556-y
• 发表时间: 2020-03
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Craig JE;Han X;Qassim A;Hassall M;Cooke Bailey JN;Kinzy TG;Khawaja AP;An J;Marshall H;Gharahkhani P;Igo RP Jr;Graham SL;Healey PR;Ong JS;Zhou T;Siggs O;Law MH;Souzeau E;Ridge B;Hysi PG;Burdon KP;Mills RA;Landers J;Ruddle JB;Agar A;Galanopoulos A;White AJR;Willoughby CE;Andrew NH;Best S;Vincent AL;Goldberg I;Radford-Smith G;Martin NG;Montgomery GW;Vitart V;Hoehn R;Wojciechowski R;Jonas JB;Aung T;Pasquale LR;Cree AJ;Sivaprasad S;Vallabh NA;NEIGHBORHOOD consortium;UK Biobank Eye and Vision Consortium;Viswanathan AC;Pasutto F;Haines JL;Klaver CCW;van Duijn CM;Casson RJ;Foster PJ;Khaw PT;Hammond CJ;Mackey DA;Mitchell P;Lotery AJ;Wiggs JL;Hewitt AW;MacGregor S
• 通讯作者: MacGregor S

RNA-Seq analysis reveals gene expression changes induced by IL-6 trans-signaling activation in retinal endothelial cells.

RNA-Seq 分析揭示了视网膜内皮细胞中 IL-6 反式信号激活诱导的基因表达变化。

• DOI: 10.1016/j.cyto.2020.155375
• 发表时间: 2021-03
• 期刊: Cytokine
• 影响因子: 3.8
• 作者: Robinson R;Brown D;Churchwell L;Lee TJ;Kodeboyina SK;Bloom J;Sharma A;Sharma S
• 通讯作者: Sharma S

Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse.

• DOI: 10.1016/j.exer.2021.108894
• 发表时间: 2022-01
• 期刊: EXPERIMENTAL EYE RESEARCH
• 影响因子: 3.4
• 作者: Xiao, Haiyan;Wang, Jing;Barwick, Shannon R.;Yoon, Yisang;Smith, Sylvia B.
• 通讯作者: Smith, Sylvia B.