Development of AS01b Mimics by Replacing QS-21 with a New Saponin Adjuvant

AS01b（由分子QS-21和MPL组成）是一种强大的佐剂，以作为fda批准的Shingrix疫苗的成分而闻名。尽管AS01b作为一种有效佐剂的成功记录，但由于皂苷分子QS-21的有限性，AS01b作为一种佐剂用于新型疫苗的可及性是一个问题。获奖者试图通过用一种新的皂苷分子取代QS-21来开发AS01b的模拟物来解决这个问题。

AS01b (composed of the molecules QS-21 and MPL) is a powerful adjuvant best known for being a component of the FDA-approved Shingrix vaccine. Despite its successful track-record as an effective adjuvant, accessibility to AS01b as an adjuvant for use in novel vaccines is a concern due to the limited nature of the saponin molecule QS-21. The awardee seeks to address this problem by developing a mimic of AS01b by replacing QS-21 with a novel saponin molecule.