Regulation of gene transcription and alternative splicing by a long non-coding RNA
长非编码RNA对基因转录和选择性剪接的调控
基本信息
- 批准号:10693874
- 负责人:
- 金额:$ 54.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgreementAlternative SplicingAmericanArginineArrhythmiaBindingBiopsyCa(2+)-Transporting ATPaseCalciumCardiacCardiac MyocytesCatecholaminergic Polymorphic Ventricular TachycardiaCatecholaminesCell NucleusCellsCessation of lifeChromatinCouplingDataDefectDevelopmentDihydropyridine ReceptorsDown-RegulationExerciseExonsFunctional disorderGene ExpressionGene Expression RegulationGenesGenetic TranscriptionHeartHeart DiseasesHeart failureHomeostasisHumanImpairmentIndividualIsoproterenolKnock-outKnockout MiceMechanicsMembraneMembrane PotentialsMessenger RNAMolecularMusMuscle CellsMutationMyocardiumNuclearPathogenesisPathologicPatientsPredispositionPromoter RegionsProtein IsoformsRNA SplicingRegulationResearchRoleRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSerineSignal TransductionSkeletal MuscleStressTranscriptTranscriptional RegulationUntranslated RNAchromosome conformation captureexercise capacitygenome-wideheart functionmRNA Precursornovel therapeuticsoverexpressionprematurepressurepromoterrecruitresponsesudden cardiac deaththerapeutic targettriadin
项目摘要
Project Summary/Abstract
Research over the past decade has revealed the importance of long non-coding RNAs (lncRNAs) in the control
of cardiac remodeling and heart failure. We have characterized a cardiac specific lncRNA in the control of
calcium handling in human and mouse cardiomyocytes. Knockout of this lncRNA causes dysregulation of
calcium handling in cardiomyocytes and impairs cardiac function. Knockout mice are susceptible to cardiac
arrhythmias caused by catecholaminergic challenging and premature death. In this project, we propose to (1)
determine mechanisms by which lncRNA regulates gene expression at the transcription level, (2) determine
how lncRNA regulates gene expression at the alternative splicing level, and (3) determine cardiac protection
conferred by lncRNA in response to pathological stresses. The results from this project have the potential to
facilitate the development of novel therapeutics for heart disease.
项目总结/摘要
过去十年的研究已经揭示了长链非编码RNA(lncRNA)在控制细胞凋亡中的重要性。
心脏重塑和心力衰竭我们已经描述了一种心脏特异性lncRNA,
人和小鼠心肌细胞中的钙处理。敲除这种lncRNA会导致
心肌细胞中的钙处理并损害心脏功能。基因敲除小鼠对心脏
引起的心律失常和过早死亡。在本项目中,我们建议(1)
确定lncRNA在转录水平调节基因表达的机制,(2)确定
lncRNA如何在可变剪接水平调节基因表达,以及(3)确定心脏保护
是由lncRNA对病理性应激的反应而产生的。该项目的成果有可能
促进心脏病新疗法的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kunhua Song其他文献
Kunhua Song的其他文献
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{{ truncateString('Kunhua Song', 18)}}的其他基金
Regulation of gene transcription and alternative splicing by a long non-coding RNA
长非编码RNA对基因转录和选择性剪接的调控
- 批准号:
10444794 - 财政年份:2022
- 资助金额:
$ 54.64万 - 项目类别:
Mechanisms for cell signaling in the control of cardiomyogenesis
控制心肌发生的细胞信号传导机制
- 批准号:
10522627 - 财政年份:2016
- 资助金额:
$ 54.64万 - 项目类别:
Mechanisms for cell signaling in the control of cardiomyogenesis
控制心肌发生的细胞信号传导机制
- 批准号:
9317530 - 财政年份:2016
- 资助金额:
$ 54.64万 - 项目类别:
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