Cellular and Molecular Microbiology Training Program

细胞和分子微生物学培训计划

• 批准号: 7653771
• 负责人: Jack J Hawiger
• 金额: $ 17.02万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7653771
• 关键词: Microbiology; Molecular; Training Programs

DESCRIPTION (provided by applicant): This renewal application seeks support for continuation of a unique and timely research training program in Cellular and Molecular Microbiology conducted by an interdisciplinary group of faculty investigators at Vanderbilt University (VU) and Meharry Medical College (MMC). These investigators represent the coalescing disciplines of microbial pathogenesis and cell biology which evolve into the growing field of cellular microbiology. The Program offers trainees with research opportunities for new discoveries in the study of the pathogen-host interactions relevant to biodefense and other microbes that cause human diseases, including Severe Acute Respiratory Syndrome (SARS). The training faculty at VU and MMC has demonstrated a highly effective commitment to 13 predoctoral students supported by this Program. The innovative features of this program are vested in state-of-the-science cell biology approaches as applied to the study of organisms important for human pathogenesis in the following areas: (i) Host-Cell Interaction with Potential Bioweapon Agents and Development of Countermeasures; (ii) Virus-Cell Interactions; (iii) Microbial Adhesion to Cellular Receptors; (iv) Microbial Cues for Cytoskeleton, Cytokinesis and Cell Cycle; (v) Endosomal-Lysosomal Pathway of Microbial Internalization and Processing; (vi) Signal Transduction and Gene Transcription Evoked by Pathogens; (vii) Nuclear Import and Export; (viii) RNA and DNA Binding Proteins in Pathogen-Host Interaction; (ix) ER and Golgi Pathways for Microbial Peptides, Glycolipids, and Glycoproteins; and (x) Mitochondria and Microbial Strategy for Survival. This well-defined Program recruits predoctoral trainees with explicit interests in cellular microbiology of pathogen-host interactions from a pool of graduate and MD/PhD students who matriculated to VU and MMC and have indicated microbiology, virology, immunology, and/or molecular cell biology as their area(s) of interest. These students are offered the Program's flagship course, "Cellular Microbiology of the Pathogen-Host Interaction." The competing application also proposes inclusion of select summer undergraduate trainees, with special emphasis on underrepresented minorities, who seek a career in the biomedical sciences. The Program is based on a stringent selection and monitoring by the Steering Committee which promotes vigorous mentorship and scientific interactions between participating laboratories and early career counseling. The Program's overall mission is to interface trainees with a highly interactive group of VU/MMC faculty and to foster the career development of new pioneers in the field of cellular microbiology of the pathogen-host interactions.

描述（由申请人提供）：此更新申请寻求支持，以继续由范德比尔特大学（VU）和梅哈里医学院（MMC）的跨学科研究人员小组进行的细胞和分子微生物学独特而及时的研究培训计划。这些研究人员代表了微生物发病机理和细胞生物学的融合学科，这些学科发展成为不断增长的细胞微生物学领域。该方案为受训人员提供研究机会，以便在研究与生物防御有关的病原体-宿主相互作用和引起人类疾病，包括严重急性呼吸系统综合症（SARS）的其他微生物方面取得新发现。在VU和MMC的培训教师已经证明了一个非常有效的承诺，13博士前的学生由该计划支持。该计划的创新特点是赋予国家的科学细胞生物学方法，适用于研究生物体的重要人类发病机制在以下领域：（一）宿主细胞与潜在的生物武器剂的相互作用和对策的发展;（二）病毒细胞相互作用;（三）微生物 粘附到细胞受体;（iv）细胞骨架、胞质分裂和细胞周期的微生物线索;（v） 微生物内化和加工的内体-溶酶体途径;（vi）病原体引起的信号转导和基因转录;（vii）核输入和输出;（viii）病原体-宿主相互作用中的RNA和DNA结合蛋白;（ix）微生物肽、糖脂和糖蛋白的ER和高尔基体途径;以及（x）线粒体和微生物生存策略。这个定义明确的计划招募博士前学员与病原体-宿主相互作用的细胞微生物学明确的兴趣从研究生和MD/博士生谁录取到VU和MMC池，并已表示微生物学，病毒学，免疫学，和/或分子细胞生物学作为他们感兴趣的领域（S）。这些学生提供该计划的旗舰课程，“病原体-宿主相互作用的细胞微生物学。“竞争性申请还建议包括选定的夏季本科学员，特别强调代表性不足的少数民族，他们寻求生物医学科学的职业生涯。该计划基于指导委员会的严格选择和监督，促进参与实验室和早期职业咨询之间的积极指导和科学互动。该计划的总体使命是将学员与VU/MMC教师的高度互动组进行交互，并促进病原体-宿主相互作用的细胞微生物学领域的新先驱的职业发展。